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dc.creatorOsés Recalde, Maddies_ES
dc.creatorMargareto, Javieres_ES
dc.creatorPortillo, María P.es_ES
dc.creatorAguilera, Concepción Maríaes_ES
dc.creatorLabayen Goñi, Idoiaes_ES
dc.date.accessioned2020-05-19T06:57:55Z
dc.date.available2020-05-19T06:57:55Z
dc.date.issued2019
dc.identifier.issn2072-6643
dc.identifier.urihttps://hdl.handle.net/2454/36914
dc.description.abstractEarly detection of obesity and its associated comorbidities in children needs priority for the development of effective therapeutic intervention. Circulating miRNAs (microRNAs) have been proposed as biomarkers for obesity and its comorbidities; therefore, we conducted a systematic review to summarize results of studies that have quantified the profile of miRNAs in children and adolescents with obesity and/or associated disorders. Nine studies aiming to examine differences in miRNA expression levels between children with normal weight and obesity or between obese children with or without cardiometabolic diseases were included in this review. We identified four miRNAs overexpressed in obesity (miR-222, miR-142–3, miR-140-5p, and miR-143) and two miRNAs (miR-122 and miR-34a) overexpressed in children with obesity and nonalcoholic fatty liver disease (NAFLD) and/or insulin resistance. In conclusion, circulating miRNAs are promising diagnostic biomarkers of obesity-associated diseases such as NAFLD and type 2 diabetes already in childhood. However, more studies in children, using massive search technology and with larger sample sizes, are required to draw any firm conclusions.en
dc.description.sponsorshipThis research was funded by the Spanish Ministry of Industry and Competitiveness (DEP2016-78377-R) and by the European Regional Development Fund (ERDF), M.O. is supported by a grant from the Spanish Ministry of Economy and Competitiveness, grant number; BES-2017-080770 and the APC was funded by additional support from the University of Granada, UGR Research and Knowledge Transfer Fund (PPIT) 2016, Excellence Actions Programme, and Excellence Actions Programe. C.M.A. and I.L.G. are part of the 'URG Plan propio de Investigación 2016' and the 'Excellence actions: Unit of Excellence on Exercise and Health (UCEES)', University of Granada.en
dc.format.extent13 p.
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherMDPIen
dc.relation.ispartofNutrients, 2019, 11 (12), 2890en
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMiRNAsen
dc.subjectChildhood obesityen
dc.subjectBiomarkersen
dc.titleCirculating miRNAs as biomarkers of obesity and obesity-associated comorbidities in children and adolescents: a systematic reviewen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoa. ISFOOD - Institute on Innovation & Sustainable Development in Food Chaines_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.identifier.doi10.3390/nu11122890
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/DEP2016-78377-Ren
dc.relation.publisherversionhttps://doi.org/10.3390/nu11122890
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.type.versionVersión publicada / Argitaratu den bertsioaes


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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY)
Except where otherwise noted, this item's license is described as © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY)