The hemodynamics of aneurysms treated with flow-diverting stents considering both stent and aneurysm/artery geometries
Fecha
2020Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Identificador del proyecto
Impacto
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10.3390/APP10155239
Resumen
Flow diverting stents are deployed to reduce the blood flow into the aneurysm, which would thereby induce thrombosis in the aneurysm sac; the stents prevent its rupture. The present study aimed to examine and quantify the impacts of different flow stents on idealized configurations of the cerebral artery. In our study, we considered a spherical sidewall aneurysm located on curved and tortuous ide ...
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Flow diverting stents are deployed to reduce the blood flow into the aneurysm, which would thereby induce thrombosis in the aneurysm sac; the stents prevent its rupture. The present study aimed to examine and quantify the impacts of different flow stents on idealized configurations of the cerebral artery. In our study, we considered a spherical sidewall aneurysm located on curved and tortuous idealized artery vessels and three stents with different porosities (70, 80 and 90%) for deployment. Using computational fluid dynamics, the local hemodynamics in the presence and absence of the stents were simulated, respectively, under the assumption that the blood flow was unsteady and non-Newtonian. The hemodynamic parameters, such as the intra-aneurysmal flow, velocity field and wall shear stress and its related indices, were examined and compared among the 12 cases simulated. The results illustrated that with the stent deployment, the intra-aneurysmal flow and the wall shear stress and its related indices were considerably modified depending on both stent and aneurysm/artery geometries, and that the intra-aneurysmal relative residence time increased rapidly with decreasing stent porosity in all the vessel configurations. These results also inform the rationale for selecting stents for treating aneurysms of different configurations. [--]
Materias
Cerebral aneurysm,
CFD,
Flow diverting stent,
Time averaged wall shear stress,
Oscillatory shear index,
Relative residence time
Editor
MDPI
Publicado en
Applied Sciences 2020, 10(15), 5239
Departamento
Universidad Pública de Navarra. Departamento de Ingeniería /
Nafarroako Unibertsitate Publikoa. Ingeniaritza Saila
Versión del editor
Entidades Financiadoras
This research was funded by the Saskatchewan Health Research Foundation (SHRF grant reference #2784). M. Malvè was supported by grant PRX17/00335 financed by the Spanish Ministry of Education within the National Program 'Salvador de Madariaga'. The support of the Spanish Ministry of Economy, Industry and Competitiveness through research project DPI2017-83259-R (AEI/FEDER, UE) and of the Department of Economic Development of the Navarra Government through research project PC086-087-088 CONDE is highly appreciated. Finally, we gratefully acknowledge the Instituto de Salud Carlos III (ISCIII) through the CIBER-BBN initiative. /
This research was funded by the Saskatchewan Health Research Foundation (SHRF grant reference #2784). M. Malvé was supported by grant PRX17/00335 financed by the Spanish Ministry of Education within the National Program "Salvador de Madariaga." The support of the Spanish Ministry of Economy, Industry and Competitiveness through research project DPI2017-83259-R (AEI/FEDER, UE) and of the Department of Economic Development of the Navarra Government through research project PC086-087-088 CONDE is highly appreciated. Finally, we gratefully acknowledge the Instituto de Salud Carlos III (ISCIII) through the CIBER-BBN initiative.