On the improvement of alveolar-like microfluidic devices for efficient blood oxygenation

Date
2021Author
Version
Acceso abierto / Sarbide irekia
Type
Artículo / Artikulua
Version
Versión aceptada / Onetsi den bertsioa
Impact
|
10.1002/admt.202001027
Abstract
In this work, we study alveolar-like microfluidic devices with a horizontal membrane arrangement that demonstrate a great potential as small-scale blood oxygenator. The design criteria for the fabricated devices were to maximize the oxygen saturation level and minimize liquid chamber volume while ensuring the physiological blood flow in order to avoid thrombus formation and channel blockage durin ...
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In this work, we study alveolar-like microfluidic devices with a horizontal membrane arrangement that demonstrate a great potential as small-scale blood oxygenator. The design criteria for the fabricated devices were to maximize the oxygen saturation level and minimize liquid chamber volume while ensuring the physiological blood flow in order to avoid thrombus formation and channel blockage during operation. The liquid chamber architecture was iteratively modified upon analysis of the fluid dynamics by computer modelling. Accordingly, two alveolar type architectures were fabricated, Alveolar Design 1 (AD1) and Alveolar Design 2 (AD2), and evaluated for oxygenation of sheep blood. The attained O2 transfer rate at 1 mL/min of blood flow rate for both devices was rather similar: 123 mL·min-1 ·m-2 and 127 mL·min-1 ·m-2 for AD1 and AD2 microfluidic devices, respectively. Among the studied, AD2 type geometry would lead to the lowest pressure drop and shear stress value upon implementation in a scaled microfluidic artificial lung (µAL) to satisfy oxygenation requirements of a 2.0 kg neonate. [--]
Subject
Membrane type microfluidic contactor,
Neonates,
Optimization by computer modeling,
Priming volume,
Simplified alveolar design
Publisher
Wiley
Published in
Advanced Materials Technologies 2021, 6, 2001027
Departament
Universidad Pública de Navarra/Nafarroako Unibertsitate Publikoa. Institute for Advanced Materials and Mathematics - INAMAT2
Publisher version
Sponsorship
Government of Aragon and the Education, Audiovisual and Culture Executive Agency (EU-EACEA) within the EUDIME – ‘Erasmus Mundus Doctorate in Membrane Engineering’ program (FPA 2011-0014, SGA 2012-1719, http://eudime.unical.it). CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008–2011 financed by the Instituto de Salud Carlos III with the assistance of the European Regional Development Fund.