Effects of resistance training intervention along with leucine-enriched whey protein supplementation on sarcopenia and frailty in post-hospitalized older adults: preliminary findings of a randomized controlled trial
Fecha
2022Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Identificador del proyecto
AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/FJC2018-037925-I
Impacto
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10.3390/jcm11010097
Resumen
Resistance training and protein supplementation are expected to exert the greatest effect in counteracting muscle-wasting conditions. Myokines might play a key role, but this remains to be elucidated. The aim of this study (NCT03815201) was to examine the effects of a resistance training program with post-exercise leucine-enriched protein supplementation on sarcopenia and frailty status and on th ...
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Resistance training and protein supplementation are expected to exert the greatest effect in counteracting muscle-wasting conditions. Myokines might play a key role, but this remains to be elucidated. The aim of this study (NCT03815201) was to examine the effects of a resistance training program with post-exercise leucine-enriched protein supplementation on sarcopenia and frailty status and on the plasma myokine concentrations of post-hospitalized older adults. A total of 41 participants were included in this 12-week resistance training intervention and randomized either to the placebo group or the protein group. Sarcopenia, frailty, body composition and blood-based myokines were measured at baseline and after 12 weeks. Both groups improved in terms of physical performance (p < 0.005) and frailty (p < 0.07) following the resistance training intervention, but without any difference between groups. Myokine concentrations did not change after the intervention in either group. Changes in myostatin concentrations were associated with greater improvements in appendicular skeletal muscle mass at the end of the intervention (p < 0.05). In conclusion, the implementation of resistance training programs after hospitalization in older adults should be prioritized to combat sarcopenia and frailty immediately. The results regarding myostatin should be taken as preliminary findings. [--]
Materias
Elderly,
Hospital,
Leucine,
Muscle mass,
Muscle wasting,
Myokine,
Myostatin,
Protein,
Strength training,
Whey protein
Editor
MDPI
Publicado en
Journal of Clinical Medicine, 11 (1), 2022
Departamento
Universidad Pública de Navarra/Nafarroako Unibertsitate Publikoa. Institute on Innovation and Sustainable Development in Food Chain - ISFOOD
Versión del editor
Entidades Financiadoras
This study was supported by the Basque Government (2016111138). M.A. was supported by a grant from the University of the Basque Country (PIF17/186). C.C.-S. is supported by the Spanish Ministry of Science and Innovation (FJC2018-037925-I). I.E. by a grant from the University of the Basque Country in collaboration with the university of Bordeaux (University of Bordeaux (UBX)) (PIFBUR16/07).