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dc.creatorFerrés‐Amat, Eduardes_ES
dc.creatorAl Madhoun, Ashrafes_ES
dc.creatorFerrés-Amat, Elviraes_ES
dc.creatorAl Demour, Saddames_ES
dc.creatorAbabneh, Mera A.es_ES
dc.creatorFerrés-Padró, Eduardes_ES
dc.creatorMarti, Carleses_ES
dc.creatorCarrió, Neuses_ES
dc.creatorBarajas Vélez, Miguel Ángeles_ES
dc.creatorAtari, Maheres_ES
dc.description.abstractBackground: bioactive chemical surface modifications improve the wettability and osse-ointegration properties of titanium implants in both animals and humans. The objective of this animal study was to investigate and compare the bioreactivity characteristics of titanium implants (BLT) pre‐treated with a novel bone bioactive liquid (BBL) and the commercially available BLT‐SLA active. Methods: forty BLT‐SLA titanium implants were placed in in four foxhound dogs. Animals were divided into two groups (n = 20): test (BLT‐SLA pre‐treated with BBL) and control (BLT‐SLA active) implants. The implants were inserted in the post extraction sockets. After 8 and 12 weeks, the animals were sacrificed, and mandibles were extracted, containing the implants and the surrounding soft and hard tissues. Bone‐to‐implant contact (BIC), inter‐thread bone area percentage (ITBA), soft tissue, and crestal bone loss were evaluated by histology and histomorphometry. Results: all animals were healthy with no implant loss or inflammation symptoms. All implants were clinically and histologically osseo‐integrated. Relative to control groups, test implants demon-strated a significant 1.5‐ and 1.7‐fold increase in BIC and ITBA values, respectively, at both assessment intervals. Crestal bone loss was also significantly reduced in the test group, as compared with controls, at week 8 in both the buccal crests (0.47 ± 0.32 vs 0.98 ± 0.51 mm, p < 0.05) and lingual crests (0.39* ± 0.3 vs. 0.89 ± 0.41 mm, p < 0.05). At week 12, a pronounced crestal bone loss improvement was observed in the test group (buccal, 0.41 ± 0.29 mm and lingual, 0.54 ± 0.23 mm). Tissue thickness showed comparable values at both the buccal and lingual regions and was significantly improved in the studied groups (0.82–0.92 mm vs. 33–48 mm in the control group). Conclusions: Relative to the commercially available BLT‐SLA active implants, BLT‐SLA pre‐treated with BBL showed improved histological and histomorphometric characteristics indicating a reduced titanium surface roughness and improved wettability, promoting healing and soft and hard tissue regeneration at the implant site.en
dc.description.sponsorshipThis research was funded by: Biointelligent Technology Systems SL, Barcelona, Spain.en
dc.format.extent15 p.
dc.relation.ispartofMaterials, 14 (20), 2021
dc.rights© 2021 by the authors. Creative Commons Attribution 4.0 Internationalen
dc.subjectBLT‐SLA activeen
dc.subjectDental implanten
dc.subjectOsseo integration dental implantationen
dc.titleHistologic and histomorphometric evaluation of a new bioactive liquid bbl on implant surface: a preclinical study in foxhound dogsen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.type.versionVersión publicada / Argitaratu den bertsioaes

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© 2021 by the authors. Creative Commons Attribution 4.0 International
Except where otherwise noted, this item's license is described as © 2021 by the authors. Creative Commons Attribution 4.0 International

El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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