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dc.creatorAzcue Sanromán, Pabloes_ES
dc.creatorEncío Martínez, Ignacioes_ES
dc.creatorGuerrero Setas, Davides_ES
dc.creatorSuarez Alecha, Javieres_ES
dc.creatorGalbete Jiménez, Arkaitzes_ES
dc.creatorMercado Gutiérrez, María R.es_ES
dc.creatorVera García, Ruthes_ES
dc.creatorGómez Dorronsoro, María Luisaes_ES
dc.date.accessioned2022-06-13T11:16:11Z
dc.date.available2022-06-13T11:16:11Z
dc.date.issued2021
dc.identifier.citationAzcue, P.; Encío, I.; Guerrero-Setas, D.; Suarez-Alecha, J.; Galbete, A.; Mercado, M.; Vera, R.; Gomez-Dorronsoro, M.L.. (2021). PD-L1 as a prognostic factor in early-stage colon carcinoma within the immunohistochemical molecular subtype classification. Cancers. 13,8 1943-1943 .en
dc.identifier.issn2072-6694
dc.identifier.urihttps://hdl.handle.net/2454/43162
dc.description.abstractColorectal cancer (CRC) is a very heterogeneous disease. Efforts to characterize and search for biomarkers for these patients are currently ongoing in the hope of establishing a more targeted therapeutic approach. The role of PD-1 ligand (PD-L1) expression as a biomarker has not yet been fully elucidated. The Consensus Molecular Subtype classification has been delineated, but although already acknowledged in the most recent international guidelines, it has yet to be implemented in clinical practice. We investigate PD-L1 expression as a biomarker of prognosis in the early-stage setting and integrate it with the Consensus Molecular Subtype (CMS), in an effort to differentiate those patients with a worse prognosis who could potentially benefit from an early, more aggressive treatment. Our results suggest PD-L1 as an independent prognostic factor in early stage setting when assessed by immunohistochemistry. Additionally, PD-L1 expression appears to be a viable biomarker to differentiate patients in the CMS (CMS2/CMS3) who lack a clear prognosis.en
dc.description.sponsorshipThis research was partly funded by European Union Regional Development Fund (17-20, RefBioII, Trans-Pyrenean cooperation network program 2016-2018, INTERREG-POCTEFA)en
dc.format.extentapplication/zipen
dc.format.extent18 p.
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherMDPIen
dc.relation.ispartofCancers 2021, 13, 1943en
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPD-L1en
dc.subjectCMSen
dc.subjectColon canceren
dc.titlePD-L1 as a prognostic factor in early-stage colon carcinoma within the immunohistochemical molecular subtype classificationen
dc.typeArtículo / Artikuluaes
dc.typeinfo:eu-repo/semantics/articleen
dc.date.updated2022-06-13T10:55:57Z
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.identifier.doi10.3390/cancers13081943
dc.relation.publisherversionhttps://doi.org/10.3390/cancers13081943
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen


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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Except where otherwise noted, this item's license is described as © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.

El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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