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dc.creatorCervilla-Martínez Juan F.es_ES
dc.creatorRodríguez-Gotor Juan J.es_ES
dc.creatorWypijewski, Krzysztof J.es_ES
dc.creatorFontán-Lozano Ángelaes_ES
dc.creatorWang, Taoes_ES
dc.creatorSantamaría, Enriquees_ES
dc.creatorFuller, Williames_ES
dc.creatorMejías Rebecaes_ES
dc.identifier.citationCervilla-Martínez, J. F., Rodríguez-Gotor, J. J., Wypijewski, K. J., Fontán-Lozano, Á., Wang, T., Santamaría, E., Fuller, W., & Mejías, R. (2022). Altered Cortical Palmitoylation Induces Widespread Molecular Disturbances in Parkinson’s Disease. International Journal of Molecular Sciences, 23(22), 14018.
dc.description.abstractThe relationship between Parkinson’s disease (PD), the second-most common neurodegenerative disease after Alzheimer’s disease, and palmitoylation, a post-translational lipid modification, is not well understood. In this study, to better understand the role of protein palmitoylation in PD and the pathways altered in this disease, we analyzed the differential palmitoyl proteome (palmitome) in the cerebral cortex of PD patients compared to controls (n = 4 per group). Data-mining of the cortical palmitome from PD patients and controls allowed us to: (i) detect a set of 150 proteins with altered palmitoylation in PD subjects in comparison with controls; (ii) describe the biological pathways and targets predicted to be altered by these palmitoylation changes; and (iii) depict the overlap between the differential palmitome identified in our study with protein interactomes of the PD-linked proteins α-synuclein, LRRK2, DJ-1, PINK1, GBA and UCHL1. In summary, we partially characterized the altered palmitome in the cortex of PD patients, which is predicted to impact cytoskeleton, mitochondrial and fibrinogen functions, as well as cell survival. Our study suggests that protein palmitoylation could have a role in the pathophysiology of PD, and that comprehensive palmitoyl-proteomics offers a powerful approach for elucidating novel cellular pathways modulated in this neurodegenerative disease.en
dc.description.sponsorshipThis work was partially funded by NIH (R21NS085358). JJRG had an Erasmus+ fellowship from an EU programme for education, training, youth, and sport. The Brain and Body Donation Program is supported by the National Institute on Aging (P30 AG19610 Arizona Alzheimer’s Disease Core Center), the Arizona Department of Health Services (contract 211002, Arizona Alzheimer’s Research Center), the Arizona Biomedical Research Commission (contracts 4001, 0011, 05-901 and 1001 to the Arizona Parkinson’s Disease Consortium)en
dc.relation.ispartofInternational Journal of Molecular Sciences, 2022, 23(22), 1-18en
dc.rights© 2022 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en
dc.subjectCerebral cortexen
dc.subjectParkinson´s diseaseen
dc.titleAltered cortical palmitoylation induces widespread molecular disturbances in Parkinson's diseaseen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.type.versionVersión publicada / Argitaratu den bertsioaes

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© 2022 by the authors. This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license.
Except where otherwise noted, this item's license is described as © 2022 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.

El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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