Clinical, histopathologic and genetic features of rhabdoid meningiomas
Fecha
2023Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Impacto
|
10.3390/ijms24021116
Resumen
Rhabdoid meningiomas (RM) shows heterogeneous histological findings, and a wide variety of chromosomal copy number alterations (CNA) are associated with an unpredictable course of the disease. In this study, we analyzed a series of 305 RM samples from patients previously reported in the literature and 33 samples from 23 patients studied in our laboratory. Monosomy 22-involving the minimal but mos ...
[++]
Rhabdoid meningiomas (RM) shows heterogeneous histological findings, and a wide variety of chromosomal copy number alterations (CNA) are associated with an unpredictable course of the disease. In this study, we analyzed a series of 305 RM samples from patients previously reported in the literature and 33 samples from 23 patients studied in our laboratory. Monosomy 22-involving the minimal but most common recurrent region loss of the 22q11.23 chromosomal region was the most observed chromosomal alteration, followed by losses of chromosomes 14, 1, 6, and 19, polysomies of chromosomes 17, 1q, and 20, and gains of 13q14.2, 10p13, and 21q21.2 chromosomal regions. Based on their CNA profile, RM could be classified into two genetic subgroups with distinct clinicopathologic features characterized by the presence of (1) chromosomal losses only and (2) combined losses and gains of several chromosomes. The latter displays a higher frequency of WHO grade 3 tumors and poorer clinical outcomes. [--]
Materias
Chromosome copy number alterations,
Diagnosis,
Histopathology,
Prognosis,
Rhabdoid meningioma,
Survival
Editor
MDPI
Publicado en
International Journal of Molecular Sciences, 2023, 24, 1116
Departamento
Universidad Pública de Navarra. Departamento de Ciencias de la Salud /
Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila
Versión del editor
Entidades Financiadoras
This research was funded by Consejería de Sanidad JCYL, Gerencia Regional de Salud,
Spain grant numbers GRS 2132/A/20 and GRS 2315/A/21 and Instituto de Salud Carlos III, Ministerio
de Economía y Competitividad, Madrid, Spain grant number CIBERONC CB16/12/00400.
Aparece en las colecciones
Los documentos de Academica-e están protegidos por derechos de autor con todos los derechos reservados, a no ser que se indique lo contrario.
La licencia del ítem se describe como © 2023 by the authors. This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license.
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Relapse, cognitive reserve and their relationship with cognition in first episode schizophrenia: a 3-year follow-up study
Sánchez Torres, Ana María ; Amoretti, Silvia; Enguita Germán, Mónica; Mezquida, Gisela; Moreno-Izco, Lucía; Panadero-Gómez, Rocío; Rementería, Lide; Toll, Alba; Rodríguez-Jiménez, Roberto; Roldán, Alexandra; Pomarol-Clotet, Edith; Ibáñez, Ángela; Usall, Judith; Contreras, Fernando; Vieta, Eduard; López-Ilundain, José M.; Merchán-Naranjo, Jessica; González Pinto, Ana; Berrocoso, Esther; Bernardo, Miguel; Cuesta, Manuel J.; Forte, María Florencia; González-Díaz, Jairo M.; Parellada, Mara; Abrokwa, Hayford; Segura, María Sans; González, Judtih Selma; Zorrilla, Iñaki; González-Ortega, Itxaso; Legido, Teresa; Mané, Anna; Sanchez-Pastor, Luis; Rentero, David; Sarró, Salvador; García-León, María Ángeles; Butjosa, Anna; Pardo, Marta; Zarzuela, Amalia; Ribeiro Fernández, María; Sáiz-Ruiz, Jerónimo; León-Quismondo, Leticia; Hernández, Miguel; Cámara, Concepción de la; Gutiérrez-Fraile, Miguel; González-Blanco, Leticia (Elsevier, 2023) Artículo / ArtikuluaSchizophrenia is frequently characterized by the presence of multiple relapses. Cognitive impairments are core features of schizophrenia. Cognitive reserve (CR) is the ability of the brain to compensate for damage caused ... -
Adherence to the Mediterranean diet reduces mortality in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain)
Buckland, Genevieve; Agudo, Antonio; Travier, Noemie; Huerta, José María; Cirera, Lluís; Tormo, María José; Navarro, Carmen; Chirlaque, María Dolores; Moreno Iribas, C.; Ardanaz, Eva; Barricarte Gurrea, Aurelio ; Etxeberria Andueza, Jaione ; Marín, Pilar; Quirós, J. Ramón; Redondo, María Luisa; Larrañaga, Nerea; Amiano, Pilar; Dorronsoro, Miren; Arriola, Larraitz; Basterretxea, Mikel; Sánchez, María José; Molina, Esther; González, Carlos A. (Cambridge University Press, 2011) Artículo / ArtikuluaEpidemiological studies show that adherence to a Mediterranean diet (MD) increases longevity; however, few studies are restricted to Mediterranean populations or explore the effect of a MD pattern that directly incorporates ... -
Splicing factor SLU7 prevents oxidative stress-mediated hepatocyte nuclear factor 4α degradation, preserving hepatic differentiation and protecting from liver damage
Gárate Rascón, María; Recalde, Miriam; Jiménez, Maddalen; Elizalde, María; Azkona, María; Uriarte, Iker; Latasa, Maria Ujue; Urtasun Alonso, Raquel ; Bilbao, Idoia; Sangro, Bruno; García Ruiz, Carmen; Fernández-Checa, José Carlos; Corrales, Fernando J.; Esquivel, Argitxu; Pineda Lucena, Antonio; Fernández-Barrena, Maite G.; Ávila, Matías A.; Arechederra, María; Berasain, Carmen (WileyAmerican Asociation for the Study of Liver Diseases, 2021) Artículo / ArtikuluaBackground and Aims: Hepatocellular dedifferentiation is emerging as an important determinant in liver disease progression. Preservation of mature hepatocyte identity relies on a set of key genes, predominantly the ...