Ultrahigh sensitive detection of tau protein as Alzheimer's biomarker via microfluidics and nanofunctionalized optical fiber sensors
Fecha
2022Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Identificador del proyecto
Impacto
|
10.1002/adpr.202200044
Resumen
Alzheimer’s disease (AD) is one of the most common neurodegenerative illnesses
displaying the highest death rate in the elderly. However, the existing AD
diagnostic system remains elusive due to lack of a technology that may ensure
enough sensitivity and reproducibility, detection accuracy, and specificity.
Herein, a straightforward approach is reported to realize lab-on-fiber (LoF)
technolo ...
[++]
Alzheimer’s disease (AD) is one of the most common neurodegenerative illnesses
displaying the highest death rate in the elderly. However, the existing AD
diagnostic system remains elusive due to lack of a technology that may ensure
enough sensitivity and reproducibility, detection accuracy, and specificity.
Herein, a straightforward approach is reported to realize lab-on-fiber (LoF)
technology for AD biomarker detection based on a D-shaped single-mode fiber
combined with nanometer-scale metal-oxide film. The proposed sensing system,
which permits the generation of lossy-mode resonance (LMR), remarkably
increases the evanescent field of light guided through the fiber, and hence the
fiber-surrounding medium interaction. Moreover, such optical sensors are highly
repeatable in results and can safely be embedded into a compact and stable
microfluidic system. Herein, the specific detection of Tau protein (as one of the
classical AD biomarkers that is highly correlated with AD progression) in a
complex biofluid with a detection limit of 10 12 M and over a wide concentration
range (10 3
–10 μg mL 1
) is successfully demonstrated. The proposed LoF
biosensor is an appealing solution for rapid, sub-microliter dose and highly
sensitive detection of analytes at low concentrations, hereby having the potential
toward early screening and personalized medicine in AD. [--]
Materias
Alzheimer's disease,
Tau protein,
Biomarkers,
Early detection
Editor
Wiley
Publicado en
Advanced Photonics Research, 2022, 3, 2200044
Departamento
Universidad Pública de Navarra/Nafarroako Unibertsitate Publikoa. Institute of Smart Cities - ISC /
Universidad Pública de Navarra. Departamento de Ingeniería Eléctrica y Electrónica /
Nafarroako Unibertsitate Publikoa. Ingeniaritza Elektrikoa eta Elektronikoa Saila
Versión del editor
Entidades Financiadoras
F.C. gratefully acknowledges the support of the National Research Council of Italy (CNR) for the Short-Term Mobility programs 2017 and 2019. I.D.V. and I.R.M. acknowledge partial support of the Spanish Ministry of Economy and Competitiveness (Nos.TEC2016-79367-C2-2-R and PID2019-106231RB-I00), the predoctoral research grants of the Public University of Navarra and the Public University of Navarra grant PJUpna1936. E.S. and J.F-I. acknowledge partial support of the Spanish Ministry of Science, Innovation and Universities (PID2019-110356RB-I00/AEI/10.13039/501100011033). T.G.gratefully acknowledges the support of the National Natural Science Foundation of China (Nos. 62035006, 61975068, and 62011530459), the Guangdong Outstanding Scientific Innovation Foundation (No.2019TX05X383), and the Program of Marine Economy Development Special Fund (Six Marine Industries) under Department of Natural Resources of Guangdong Province (No. GDNRC [2021]33).