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dc.creatorÁlvarez de Eulate León, Maideres_ES
dc.date.accessioned2012-03-13T08:36:21Z
dc.date.available2012-03-13T08:36:21Z
dc.date.issued2011
dc.identifier.other0000577674es_ES
dc.identifier.urihttps://hdl.handle.net/2454/4663
dc.description.abstractThe objective of this work is to investigate alternative methods to distinguish between the first three types of the Long-QT syndrome by looking for differences in simulated Body Surface Potential Maps (BSMP). Research in this area would provide a better understanding of the voltage distribution affected by the mutations. A model of human ventricular myocytes was adapted to represent the behavior of the mutated channels and BSMP were simulated including the subtypes. Chapter two illustrates the heart structure both microscopically and macroscopically, giving a short introduction on cardiac anatomy and electrophysiology in order to provide the basics to get a better understanding of the theory behind this project. The Long-QT syndrome is described in chapter three. After an overview, channel kinetics and mutations behind this pathology are detailed for each of the studied subtypes. Current diagnosis methods are also explained and disadvantages are exposed. The methods and procedures followed in this study are explained in depth in chapter four. Starting with electrophysiological modeling until BSPM simulation all the techniques and processes that were carried out are described together with the necessary mathematical background. That leads to chapter five, where all the obtained results are displayed. Finally, chapter 6 provides a summary of the project and chapter 7 describes the limitations of this work and points out perspectives for future investigations.en
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/zipen
dc.language.isoengen
dc.subjectSíndrome de QT largoes_ES
dc.subjectLong QT syndromeen
dc.subjectBody surface potential mapsen
dc.titleDiscriminating long-QT syndromes 1, 2 and 3 in simulated body surface potential mapsen
dc.typeinfo:eu-repo/semantics/masterThesisen
dc.typeProyecto Fin de Carrera / Ikasketen Amaierako Proiektuaes
dc.contributor.affiliationEscuela Técnica Superior de Ingenieros Industriales y de Telecomunicaciónes_ES
dc.contributor.affiliationTelekomunikazio eta Industria Ingeniarien Goi Mailako Eskola Teknikoaeu
dc.contributor.affiliationKarlsruhe Institute of Technology (Alemania)en
dc.contributor.departmentUniversidad Pública de Navarra. Departamento de Ingeniería Eléctrica y Electrónicaes_ES
dc.contributor.departmentNafarroako Unibertsitate Publikoa. Ingeniaritza Elektriko eta Elektronikoa Sailaeu
dc.description.degreeIngeniería de Telecomunicaciónes_ES
dc.description.degreeTelekomunikazio Ingeniaritzaeu
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.contributor.advisorTFESanchis Gúrpide, Pabloes_ES


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