• Replacing pooling functions in Convolutional Neural Networks by linear combinations of increasing functions 

  Rodríguez Martínez, Iosu  ; Lafuente López, Julio  ; Santiago, Regivan H.N.; Pereira Dimuro, Graçaliz  ; Herrera, Francisco; Bustince Sola, Humberto   (Elsevier, 2022)   Artículo / Artikulua  

  Traditionally, Convolutional Neural Networks make use of the maximum or arithmetic mean in order to reduce the features extracted by convolutional layers in a downsampling process known as pooling. However, there is no ...

• Molecular mechanisms of programmed cell death-1 dependent T cell suppression: relevance for immunotherapy 

  Zuazo Ibarra, Miren  ; Gato Cañas, María; Llorente, Noelia; Ibañez Vea, Maria; Arasanz Esteban, Hugo; Kochan, Grazyna; Escors, David (AME Publishing, 2017)   Artículo / Artikulua  

  Programmed cell death-1 (PD1) has become a significant target for cancer immunotherapy. PD1 and its receptor programmed cell death 1 ligand 1 (PDL1) are key regulatory physiological immune checkpoints that maintain ...

• PDL1 signals through conserved sequence motifs to overcome interferon-mediated cytotoxicity 

  Gato Cañas, María; Zuazo Ibarra, Miren  ; Arasanz Esteban, Hugo; Ibañez Vea, Maria; Lorenzo, Laura; Fernandez-Hinojal, Gonzalo; Vera García, Ruth; Smerdou, Cristian; Martisova, Eva; Arozarena, Imanol; Wellbrock, Claudia; Llopiz, Diana; Ruiz, Marta; Sarobe, Pablo; Breckpot, Karine; Kochan, Grazyna; Escors, David (Elsevier, 2017)   Artículo / Artikulua  

• PD1 signal transduction pathways in T cells 

  Arasanz Esteban, Hugo; Gato Cañas, María; Zuazo Ibarra, Miren  ; Ibáñez-Vea, María  ; Breckpot, Karine; Kochan, Grazyna; Escors, David (2017)   Artículo / Artikulua  

  The use of immune checkpoint inhibitors for the treatment of cancer is revolutionizing oncology. Amongst these therapeutic agents, antibodies that block PD-L1/PD1 interactions between cancer cells and T cells are demonstrating ...

• PD-L1 Expression in Systemic Immune Cell Populations as a Potential Predictive Biomarker of Responses to PD-L1/PD-1 Blockade Therapy in Lung Cancer 

  Bocanegra, Ana; Fernandez-Hinojal, Gonzalo; Zuazo Ibarra, Miren  ; Arasanz Esteban, Hugo; Garcia-Granda, María Jesús; Hernandez, Carlos; Ibañez Vea, Maria; Hernandez-Marin, Berta; Martinez-Aguillo, Maite; Lecumberri, María José; Fernandez de Lascoiti, Ángela; Teijeira, Lucía; Morilla, idoia; Vera, Ruth; Escors Murugarren, David; Kochan, Grazyna (MDPI, 2019)   Artículo / Artikulua  

  PD-L1 tumor expression is a widely used biomarker for patient stratification in PD-L1/PD-1 blockade anticancer therapies, particularly for lung cancer. However, the reliability of this marker is still under debate. Moreover, ...

View more