Envíos recientes

  • Calcium inhibits bap-dependent multicellular behavior in Staphylococcus aureus 

    Arrizubieta, M. J.; Toledo Arana, Alejandro Upna; Amorena Zabalza, Beatriz Upna; Penadés, José R.; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2004)   Artículo / Artikulua  OpenAccess
    Bap (biofilm-associated protein) is a 254-kDa staphylococcal surface protein implicated in formation of biofilms by staphylococci isolated from chronic mastitis infections. The presence of potential EF-hand motifs in the ...
  • Bap, a Staphylococcus aureus surface protein involved in biofilm formation 

    Cucarella, C.; Solano Goñi, Cristina Upna; Valle Turrillas, Jaione Upna; Amorena Zabalza, Beatriz Upna; Lasa Uzcudun, Íñigo Upna; Penadés, José R. (American Society for Microbiology, 2001)   Artículo / Artikulua  OpenAccess
    Identification of new genes involved in biofilm formation is needed to understand the molecular basis of strain variation and the pathogenic mechanisms implicated in chronic staphylococcal infections. A biofilm-producing ...
  • Conditional mutation of an essential putative glycoprotease eliminates autolysis in Staphylococcus aureus 

    Zheng, L.; Yu, C.; Bayles, K.; Lasa Uzcudun, Íñigo Upna; Ji, Y. (American Society for Microbiology, 2007)   Artículo / Artikulua  OpenAccess
    Our previous studies demonstrated that a putative Staphylococcus aureus glycoprotease (Gcp) is essential for bacterial survival, indicating that Gcp may be a novel target for developing antibacterial agents. However, the ...
  •  B regulates IS256-mediated Staphylococcus aureus biofilm phenotypic variation 

    Valle Turrillas, Jaione Upna; Vergara Irigaray, Marta Upna; Merino, Nekane; Penades, J. R.; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2007)   Artículo / Artikulua  OpenAccess
    Biofilm formation in Staphylococcus aureus is subject to phase variation, and biofilm-negative derivatives emerge sporadically from a biofilm-positive bacterial population. To date, the only known mechanism for generating ...
  • Glycogen phosphorylase, the product of the glgP Gene, catalyzes glycogen breakdown by removing glucose units from the nonreducing ends in Escherichia coli 

    Alonso-Casajus, Nora; Dauvillee, David; Viale, Alejandro Miguel; Muñoz Pérez, Francisco José; Baroja Fernández, Edurne Upna; Morán Zorzano, María Teresa; Eydallin, Gustavo Upna; Ball, Steven; Pozueta Romero, Javier Upna (American Society for Microbiology, 2006)   Artículo / Artikulua  OpenAccess
    To understand the biological function of bacterial glycogen phosphorylase (GlgP), we have produced and characterized Escherichia coli cells with null or altered glgP expression. glgP deletion mutants (ΔglgP) totally lacked ...
  • Staphylococcus aureus pathogenicity island DNA is packaged in particles composed of phage proteins 

    Tormo, María Ángeles; Ferrer, María Desamparados; Maiques, Elisa; Ubeda, Carles; Selva, Laura; Lasa Uzcudun, Íñigo Upna; Calvete, Juan J.; Novick, Richard P.; Penadés, José R. (American Society for Microbiology, 2008)   Artículo / Artikulua  OpenAccess
    Staphylococcus aureus pathogenicity islands (SaPIs) have an intimate relationship with temperate staphylococcal phages. During phage growth, SaPIs are induced to replicate and are efficiently encapsidated into special small ...
  • Role of staphylococcal phage and SaPI integrase in intra- and interspecies SaPI transfer 

    Maiques, Elisa; Ubeda, Carles; Tormo, María Ángeles; Ferrer, María Desamparados; Lasa Uzcudun, Íñigo Upna; Novick, Richard P.; Penadés, José R. (American Society for Microbiology, 2007)   Artículo / Artikulua  OpenAccess
    SaPIbov2 is a member of the SaPI family of staphylococcal pathogenicity islands and is very closely related to SaPIbov1. Typically, certain temperate phages can induce excision and replication of one or more of these islands ...
  • Protein A-mediated multicellular behavior in Staphylococcus aureus 

    Merino, Nekane; Toledo Arana, Alejandro Upna; Vergara Irigaray, Marta Upna; Valle Turrillas, Jaione Upna; Solano Goñi, Cristina Upna; Calvo, Enrique; Lopez, Juan Antonio; Foster, Timothy J.; Penadés, José R.; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2008)   Artículo / Artikulua  OpenAccess
    The capacity of Staphylococcus aureus to form biofilms on host tissues and implanted medical devices is one of the major virulence traits underlying persistent and chronic infections. The matrix in which S. aureus cells ...
  • Role of biofilm-associated protein bap in the pathogenesis of bovine Staphylococcus aureus 

    Cucarella, Carme; Tormo, M. Ángeles; Ubeda, Carles; Trotonda, M. Pilar; Monzon, Marta; Peris, Cristòfol; Amorena Zabalza, Beatriz Upna; Lasa Uzcudun, Íñigo Upna; Penadés, José R. (American Society for Microbiology, 2004)   Artículo / Artikulua  OpenAccess
    Staphylococcus aureus is a common cause of intramammary infections, which frequently become chronic, associated with the ability of the bacteria to produce biofilm. Here, we report a relationship between the ability to ...
  • Expression of the biofilm-associated protein interferes with host protein receptors of Staphylococcus aureus and alters the infective process 

    Cucarella, Carme; Tormo, M. Ángeles; Knecht, Erwin; Amorena Zabalza, Beatriz Upna; Lasa Uzcudun, Íñigo Upna; Foster, Timothy J.; Penadés, José R. (American Society for Microbiology, 2002)   Artículo / Artikulua  OpenAccess
    The adherence of Staphylococcus aureus to soluble proteins and extracellular-matrix components of the host is one of the key steps in the pathogenesis of staphylococcal infections. S. aureus presents a family of adhesins ...
  • Relevant role of fibronectin-binding proteins in Staphylococcus aureus biofilm-associated foreign-body infections 

    Vergara Irigaray, Marta Upna; Valle Turrillas, Jaione Upna; Merino, Nekane; Latasa Osta, Cristina Upna; García Martínez, Begoña Upna; Ruiz de los Mozos Aliaga, Igor; Solano Goñi, Cristina Upna; Toledo Arana, Alejandro Upna; Penadés, José R.; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2009)   Artículo / Artikulua  OpenAccess
    Staphylococcus aureus can establish chronic infections on implanted medical devices due to its capacity to form biofilms. Analysis of the factors that assemble cells into a biofilm has revealed the occurrence of strains ...
  • Overexpression of the recA gene decreases oral but not intraperitoneal fitness of Salmonella enterica 

    Medina-Ruiz, Laura; Campoy, Susana; Latasa Osta, Cristina Upna; Cardenas, Paula; Alonso, Juan Carlos; Barbe, Jordi (American Society for Microbiology, 2010)   Artículo / Artikulua  OpenAccess
    Transcription of the Salmonella enterica recA gene is negatively controlled by the LexA protein, the repressor of the SOS response. The introduction of a mutation (recAo6869) in the LexA binding site, in the promoter region ...
  • Relative contributions of lipooligosaccharide inner and outer core modifications to nontypeable Haemophilus influenzae pathogenesis 

    Morey, Pau; Viadas Martínez, Cristina Upna; Euba, Begoña; Hood, Derek W.; Barberán, Montserrat; Gil Puig, Carmen Upna; Grilló Dolset, María Jesús; Bengoechea, José Antonio; Garmendia García, Juncal (American Society for Microbiology, 2013)   Artículo / Artikulua  OpenAccess
    Nontypeable Haemophilus influenzae (NTHi) is a frequent commensal of the human nasopharynx that causes opportunistic infection in immunocompromised individuals. Existing evidence associates lipooligosaccharide (LOS) with ...
  • Role of the Omp25/Omp31 family in outer membrane properties and virulence of Brucella ovis 

    Caro-Hernandez, Paola; Fernandez-Lago, Luis; Miguel, María Jesús de; Martin-Martin, Ana I.; Cloeckaert, Axel; Grilló Dolset, María Jesús; Vizcaino, Nieves (American Society for Microbiology, 2007)   Artículo / Artikulua  OpenAccess
    The genes coding for the five outer membrane proteins (OMPs) of the Omp25/Omp31 family expected to be located in the outer membrane (OM) of rough virulent Brucella ovis PA were inactivated to evaluate their role in virulence ...
  • Modeling Klebsiella pneumoniae pathogenesis by infection of the wax moth Galleria mellonella 

    Insua, José Luis; Llobet, Enrique; Moranta, David; Pérez-Gutiérrez, Camino; Tomás, Anna; Garmendia García, Juncal; Bengoechea, José A. (American Society for Microbiology, 2013)   Artículo / Artikulua  OpenAccess
    The implementation of infection models that approximate human disease is essential for understanding pathogenesis at the molecular level and for testing new therapies before they are entered into clinical stages. Insects ...
  • BvrR/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulence 

    Manterola, Lorea; Guzman-Verri, Caterina; Chaves-Olarte, Esteban; Barquero-Calvo, Elías; Miguel, María Jesús de; Moriyon, Ignacio; Grilló Dolset, María Jesús; Lopez-Goni, Ignacio; Moreno, Edgardo (American Society for Microbiology, 2007)   Artículo / Artikulua  OpenAccess
    The Brucella abortus two-component regulatory system BvrR/BvrS controls the expression of outer membrane proteins (Omp) Omp3a (Omp25) and Omp3b (Omp22). Disruption of bvrS or bvrR generates avirulent mutants with altered ...
  • Genomic sequences of five Helicoverpa armigera nucleopolyhedrovirus genotypes from Spain that differ in their insecticidal properties 

    Arrizubieta Celaya, Maite; Simón de Goñi, Oihane; Williams, Trevor Upna; Caballero Murillo, Primitivo Upna (American Society for Microbiology, 2015)   Artículo / Artikulua  OpenAccess
    Helicoverpa armigera nucleopolyhedrovirus (HearNPV) has proved effective as the basis for various biological insecticides. Complete genome sequences of five Spanish HearNPV genotypes differed principally in the homologous ...
  • Superinfection exclusion in alphabaculovirus infections is concomitant with actin reorganization 

    Beperet Arive, Inés Upna; Irons, Sarah L.; Simón de Goñi, Oihane; King, Linda A.; Williams, Trevor Upna; Possee, Robert D.; López Ferber, Miguel; Caballero Murillo, Primitivo Upna (American Society for Microbiology, 2014)   Artículo / Artikulua  OpenAccess
    Superinfection exclusion is the ability of an established virus to interfere with a second virus infection. This effect was studied in vitro during lepidopteran-specific nucleopolyhedrovirus (genus Alphabaculovirus, family ...
  • Mixtures of complete and pif1- and pif2-deficient genotypes are required for increased potency of an insect nucleopolyhedrovirus 

    Clavijo Palacios, Gabriel; Williams, Trevor Upna; Simón de Goñi, Oihane; Muñoz, Delia Upna; Cerutti, Martine; López Ferber, Miguel; Caballero Murillo, Primitivo Upna (American Society for Microbiology, 2009)   Artículo / Artikulua  OpenAccess
    The insecticidal potency of a nucleopolyhedrovirus population (SfNIC) that infects Spodoptera frugiperda (Lepidoptera) is greater than the potency of any of the component genotypes alone. Occlusion bodies (OBs) produced ...
  • Sf29 Gene of Spodoptera frugiperda multiple nucleopolyhedrovirus is a viral factor that determines the number of virions in occlusion bodies 

    Simón de Goñi, Oihane; Williams, Trevor Upna; Asensio, Aarón C.; Ros Terés, Sarhay; Gaya Cacho, Andrea; Caballero Murillo, Primitivo Upna; Possee, Robert D. (American Society for Microbiology, 2008)   Artículo / Artikulua  OpenAccess
    The genome of Spodoptera frugiperda multiple nucleopolyhedrovirus (NPV) was inserted into a bacmid (Sfbac) and used to produce a mutant lacking open reading frame 29 (Sf29null). Sf29null bacmid DNA was able to generate ...

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