• Binding of Bacillus thuringiensis subsp. israelensis Cry4Ba to Cyt1Aa has an important role in synergism 

  Cantón, Pablo Emiliano; Zanicthe Reyes, Esmeralda; Ruiz de Escudero Fuentemilla, Íñigo; Bravo, Alejandra; Soberón, Mario (Elsevier, 2011)   Artículo / Artikulua  

  Bacillus thuringiensis subsp. israelensis (Bti) produces at least four different crystal proteins that are specifically toxic to different mosquito species and that belong to two non-related family of toxins, Cry and ...

• Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands 

  Tormo Más, María Ángeles; Mir, Ignacio; Shrestha, Archana; Tallent, Sandra M.; Campoy Sánchez, Susana; Lasa Uzcudun, Íñigo ; Barbé, Jordi; Novick, Richard P.; Christie, Gail E.; Penadés, José R. (Nature Research, 2010)   Artículo / Artikulua  

  Staphylococcal superantigen-carrying pathogenicity islands (SaPIs) are discrete, chromosomally integrated units of ∼15 kilobases that are induced by helper phages to excise and replicate. SaPI DNA is then efficiently ...

• The amino- and carboxyl-terminal fragments of the Bacillus thuringensis Cyt1Aa toxin have differential roles on toxin oligomerization and pore formation 

  Rodríguez Almazán, Claudia; Ruiz de Escudero Fuentemilla, Íñigo; Cantón, Pablo Emiliano; Muñoz Garay, Carlos; Pérez, Claudia; Gill, Sarjeet S.; Soberón, Mario; Bravo, Alejandra (American Chemical Society, 2011)   Artículo / Artikulua  

  The Cyt toxins produced by the bacteria Bacillus thuringiensis show insecticidal activity against some insects, mainly dipteran larvae, being able to kill mosquitoes and black flies. However, they also possess a general ...

• Near-infrared fluorescence imaging as an alternative to bioluminescent bacteria to monitor biomaterial-associated infections 

  Dinjaski, Nina; Shalu, Suri; Valle Turrillas, Jaione ; Lehman, Susan M.; Lasa Uzcudun, Íñigo ; Prieto, María Auxiliadora; García, Andrés J. (Elsevier, 2014)   Artículo / Artikulua  

  Biomaterial-associated infection is one of the most common complications related with the implantation of any biomedical device. Several in vivo imaging platforms have emerged as powerful diagnostic tools to longitudinally ...

• Overexpression of thioredoxin m in tobacco chloroplasts inhibits the protein kinase STN7 and alters photosynthetic performance 

  Ancín Rípodas, María ; Fernández San Millán, Alicia ; Larraya Reta, Luis María ; Morales Iribas, Fermín; Veramendi Charola, Jon ; Aranjuelo Michelena, Iker; Farrán Blanch, Inmaculada  (Oxford University Press, 2019)   Artículo / Artikulua  

  The activity of the protein kinase STN7, involved in phosphorylation of the light-harvesting complex II (LHCII) proteins, has been reported as being co-operatively regulated by the redox state of the plastoquinone pool ...

• Calcium inhibits bap-dependent multicellular behavior in Staphylococcus aureus 

  Arrizubieta, M. J.; Toledo Arana, Alejandro ; Amorena Zabalza, Beatriz ; Penadés, José R.; Lasa Uzcudun, Íñigo  (American Society for Microbiology, 2004)   Artículo / Artikulua  

  Bap (biofilm-associated protein) is a 254-kDa staphylococcal surface protein implicated in formation of biofilms by staphylococci isolated from chronic mastitis infections. The presence of potential EF-hand motifs in the ...

• Bap, a Staphylococcus aureus surface protein involved in biofilm formation 

  Cucarella, Carme; Solano Goñi, Cristina ; Valle Turrillas, Jaione ; Amorena Zabalza, Beatriz ; Lasa Uzcudun, Íñigo ; Penadés, José R. (American Society for Microbiology, 2001)   Artículo / Artikulua  

  Identification of new genes involved in biofilm formation is needed to understand the molecular basis of strain variation and the pathogenic mechanisms implicated in chronic staphylococcal infections. A biofilm-producing ...

• Conditional mutation of an essential putative glycoprotease eliminates autolysis in Staphylococcus aureus 

  Zheng, L.; Yu, C.; Bayles, K.; Lasa Uzcudun, Íñigo ; Ji, Y. (American Society for Microbiology, 2007)   Artículo / Artikulua  

  Our previous studies demonstrated that a putative Staphylococcus aureus glycoprotease (Gcp) is essential for bacterial survival, indicating that Gcp may be a novel target for developing antibacterial agents. However, the ...

• B regulates IS256-mediated Staphylococcus aureus biofilm phenotypic variation 

  Valle Turrillas, Jaione ; Vergara Irigaray, Marta ; Merino, Nekane; Penadés, José R.; Lasa Uzcudun, Íñigo  (American Society for Microbiology, 2007)   Artículo / Artikulua  

  Biofilm formation in Staphylococcus aureus is subject to phase variation, and biofilm-negative derivatives emerge sporadically from a biofilm-positive bacterial population. To date, the only known mechanism for generating ...

• Glycogen phosphorylase, the product of the glgP Gene, catalyzes glycogen breakdown by removing glucose units from the nonreducing ends in Escherichia coli 

  Alonso-Casajus, Nora; Dauvillee, David; Viale, Alejandro M. ; Muñoz Pérez, Francisco José; Baroja Fernández, Edurne ; Morán Zorzano, María Teresa; Eydallin, Gustavo ; Ball, Steven; Pozueta Romero, Javier  (American Society for Microbiology, 2006)   Artículo / Artikulua  

  To understand the biological function of bacterial glycogen phosphorylase (GlgP), we have produced and characterized Escherichia coli cells with null or altered glgP expression. glgP deletion mutants (ΔglgP) totally lacked ...

• Staphylococcus aureus pathogenicity island DNA is packaged in particles composed of phage proteins 

  Tormo Más, María Ángeles; Ferrer, María Desamparados; Maiques, Elisa; Ubeda, Carles; Selva, Laura; Lasa Uzcudun, Íñigo ; Calvete, Juan J.; Novick, Richard P.; Penadés, José R. (American Society for Microbiology, 2008)   Artículo / Artikulua  

  Staphylococcus aureus pathogenicity islands (SaPIs) have an intimate relationship with temperate staphylococcal phages. During phage growth, SaPIs are induced to replicate and are efficiently encapsidated into special small ...

• Protein A-mediated multicellular behavior in Staphylococcus aureus 

  Merino, Nekane; Toledo Arana, Alejandro ; Vergara Irigaray, Marta ; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Calvo, Enrique; Lopez, Juan Antonio; Foster, Timothy J.; Penadés, José R.; Lasa Uzcudun, Íñigo  (American Society for Microbiology, 2008)   Artículo / Artikulua  

  The capacity of Staphylococcus aureus to form biofilms on host tissues and implanted medical devices is one of the major virulence traits underlying persistent and chronic infections. The matrix in which S. aureus cells ...

• Role of staphylococcal phage and SaPI integrase in intra- and interspecies SaPI transfer 

  Maiques, Elisa; Ubeda, Carles; Tormo Más, María Ángeles; Ferrer, María Desamparados; Lasa Uzcudun, Íñigo ; Novick, Richard P.; Penadés, José R. (American Society for Microbiology, 2007)   Artículo / Artikulua  

  SaPIbov2 is a member of the SaPI family of staphylococcal pathogenicity islands and is very closely related to SaPIbov1. Typically, certain temperate phages can induce excision and replication of one or more of these islands ...

• Role of biofilm-associated protein bap in the pathogenesis of bovine Staphylococcus aureus 

  Cucarella, Carme; Tormo Más, María Ángeles; Ubeda, Carles; Trotonda, María Pilar; Monzon, Marta; Peris, Cristòfol; Amorena Zabalza, Beatriz ; Lasa Uzcudun, Íñigo ; Penadés, José R. (American Society for Microbiology, 2004)   Artículo / Artikulua  

  Staphylococcus aureus is a common cause of intramammary infections, which frequently become chronic, associated with the ability of the bacteria to produce biofilm. Here, we report a relationship between the ability to ...

• Expression of the biofilm-associated protein interferes with host protein receptors of Staphylococcus aureus and alters the infective process 

  Cucarella, Carme; Tormo Más, María Ángeles; Knecht, Erwin; Amorena Zabalza, Beatriz ; Lasa Uzcudun, Íñigo ; Foster, Timothy J.; Penadés, José R. (American Society for Microbiology, 2002)   Artículo / Artikulua  

  The adherence of Staphylococcus aureus to soluble proteins and extracellular-matrix components of the host is one of the key steps in the pathogenesis of staphylococcal infections. S. aureus presents a family of adhesins ...

• Relevant role of fibronectin-binding proteins in Staphylococcus aureus biofilm-associated foreign-body infections 

  Vergara Irigaray, Marta ; Valle Turrillas, Jaione ; Merino, Nekane; Latasa Osta, Cristina ; García Martínez, Begoña ; Ruiz de los Mozos Aliaga, Igor; Solano Goñi, Cristina ; Toledo Arana, Alejandro ; Penadés, José R.; Lasa Uzcudun, Íñigo  (American Society for Microbiology, 2009)   Artículo / Artikulua  

  Staphylococcus aureus can establish chronic infections on implanted medical devices due to its capacity to form biofilms. Analysis of the factors that assemble cells into a biofilm has revealed the occurrence of strains ...

• Overexpression of the recA gene decreases oral but not intraperitoneal fitness of Salmonella enterica 

  Medina-Ruiz, Laura; Campoy Sánchez, Susana; Latasa Osta, Cristina ; Cardenas, Paula; Alonso, Juan Carlos; Barbé, Jordi (American Society for Microbiology, 2010)   Artículo / Artikulua  

  Transcription of the Salmonella enterica recA gene is negatively controlled by the LexA protein, the repressor of the SOS response. The introduction of a mutation (recAo6869) in the LexA binding site, in the promoter region ...

• Relative contributions of lipooligosaccharide inner and outer core modifications to nontypeable Haemophilus influenzae pathogenesis 

  Morey, Pau; Viadas Martínez, Cristina ; Euba, Begoña; Hood, Derek W.; Barberán, Montserrat; Gil Puig, Carmen ; Grilló Dolset, María Jesús; Bengoechea, José Antonio; Garmendia García, Juncal (American Society for Microbiology, 2013)   Artículo / Artikulua  

  Nontypeable Haemophilus influenzae (NTHi) is a frequent commensal of the human nasopharynx that causes opportunistic infection in immunocompromised individuals. Existing evidence associates lipooligosaccharide (LOS) with ...

• Role of the Omp25/Omp31 family in outer membrane properties and virulence of Brucella ovis 

  Caro-Hernandez, Paola; Fernandez-Lago, Luis; Miguel, María Jesús de; Martin-Martin, Ana I.; Cloeckaert, Axel; Grilló Dolset, María Jesús; Vizcaíno, Nieves (American Society for Microbiology, 2007)   Artículo / Artikulua  

  The genes coding for the five outer membrane proteins (OMPs) of the Omp25/Omp31 family expected to be located in the outer membrane (OM) of rough virulent Brucella ovis PA were inactivated to evaluate their role in virulence ...

• Modeling Klebsiella pneumoniae pathogenesis by infection of the wax moth Galleria mellonella 

  Insua, José Luis; Llobet, Enrique; Moranta, David; Pérez Gutiérrez, Camino; Tomás, Anna; Garmendia García, Juncal; Bengoechea, José A. (American Society for Microbiology, 2013)   Artículo / Artikulua  

  The implementation of infection models that approximate human disease is essential for understanding pathogenesis at the molecular level and for testing new therapies before they are entered into clinical stages. Insects ...

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