• Effect of transcriptional activators SoxS, RobA, and RamA on expression of multidrug efflux pump AcrAB-TolC in enterobacter cloacae 

  Pérez, Astrid; Poza, Margarita; Aranda, Jesús; Latasa Osta, Cristina ; Medrano, Francisco Javier; Tomás, María; Romero, Antonio; Lasa Uzcudun, Íñigo ; Bou, Germán (American Society for Microbiology, december 2012, vol. 56, nº 12, p. 6256–6266, 2012)   Artículo / Artikulua  

  Control of membrane permeability is a key step in regulating the intracellular concentration of antibiotics. Efflux pumps confer innate resistance to a wide range of toxic compounds such as antibiotics, dyes, detergents, ...

• Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate 

  Perez, A.; Canle, D.; Latasa Osta, Cristina ; Poza, M.; Beceiro, A.; del, Mar Tomas; Fernandez, A.; Mallo, S.; Perez, S.; Molina, F.; Villanueva, R.; Lasa Uzcudun, Íñigo ; Bou, Germán (American Society for Microbiology, 2007)   Artículo / Artikulua  

  Enterobacter cloacae is an emerging clinical pathogen that may be responsible for nosocomial infections. Management of these infections is often difficult, owing to the high frequency of strains that are resistant to ...

• A chloroplast-derivedToxoplasma gondiiGRA4 antigen used as an oral vaccine protects against toxoplasmosis in mice 

  Yácono, María del L.; Farrán Blanch, Inmaculada ; Becher, Melina L.; Sander, Valeria; Sánchez, Vanesa R.; Martín, Valentina; Veramendi Charola, Jon ; Clemente, Marina (Wiley, 2012)   Artículo / Artikulua  

  The parasitic protozoan Toxoplasma gondii, the causal agent of toxoplasmosis, can infect most mammals and birds. In human medicine, T. gondii can cause complications in pregnant women and immunodeficient individuals, while ...

• Overexpression of plastidial thioredoxin f leads to enhanced starch accumulation in tobacco leaves 

  Sanz Barrio, Ruth; Corral-Martinez, Patricia; Ancín Rípodas, María ; Segui-Simarro, Jose; Farrán Blanch, Inmaculada  (Wiley, 2013)   Artículo / Artikulua  

  Starch, the most abundant storage carbohydrate in plants, has been a major feedstock for first‐generation biofuels. Growing fuel demands require, however, that the starch yields of energy crops be improved. Leaf starch is ...

• Tobacco plastidial thioredoxins as modulators of recombinant protein production in transgenic chloroplasts 

  Sanz Barrio, Ruth; Fernández San Millán, Alicia ; Corral-Martínez, Patricia; Seguí-Simarro, José M.; Farrán Blanch, Inmaculada  (Wiley, 2011)   Artículo / Artikulua  

  Thioredoxins (Trxs) are small ubiquitous disulphide proteins widely known to enhance expression and solubility of recombinant proteins in microbial expression systems. Given the common evolutionary heritage of chloroplasts ...

• Enhancing the expression of starch synthase class IV results in increased levels of both transitory and long-term storage starch 

  Gámez-Arjona, Francisco M.; Li, Jun; Raynaud, Sandy; Baroja Fernández, Edurne ; Muñoz Pérez, Francisco José; Ovecka, Miroslav; Ragel, Paula; Bahaji, Abdellatif; Pozueta Romero, Javier ; Mérida, Ángel (Wiley, 2011)   Artículo / Artikulua  

  Starch is an important renewable raw material with an increasing number of applications. Several attempts have been made to obtain plants that produce modified versions of starch or higher starch yield. Most of the approaches ...

• Human papillomavirus L1 protein expressed in tobacco chloroplasts self-assembles into virus-like particles that are highly immunogenic 

  Fernández San Millán, Alicia ; Martín Ortigosa, Susana; Hervás Stubbs, Sandra ; Corral-Martínez, Patricia; Seguí-Simarro, José M.; Gaétan, Julien; Coursaget, Pierre; Veramendi Charola, Jon  (Wiley, 2008)   Artículo / Artikulua  

  Cervical cancer is the second most prevalent cancer in women worldwide. It is linked to infection with human papillomavirus (HPV). As the virus cannot be propagated in culture, vaccines based on virus‐like particles have ...

• High-density seedling expression system for the production of bioactive human cardiotrophin-1, a potential therapeutic cytokine, in transgenic tobacco chloroplasts 

  Farrán Blanch, Inmaculada ; Río-Manterola, Francisco; Íñiguez, María; Gárate, Sonia; Prieto, Jesús; Mingo Castel, Ángel (Wiley, 2008)   Artículo / Artikulua  

  Histidine‐tagged human cardiotrophin‐1 (hCT‐1), a recently discovered cytokine with excellent therapeutic potential, was expressed in tobacco chloroplasts under the transcriptional and translational control of two different ...

• The enterococcal surface protein, Esp, is involved in Enterococcus faecalis biofilm formation 

  Toledo Arana, Alejandro ; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Arrizubieta Balerdi, María Jesús; Cucarella, Carme; Lamata, Marta; Amorena Zabalza, Beatriz ; Leiva, José; Penadés, José R.; Lasa Uzcudun, Íñigo  (American Society for Microbiology, 2001)   Artículo / Artikulua  

  The enterococcal surface protein, Esp, is a high-molecular-weight surface protein of unknown function whose frequency is significantly increased among infection-derived Enterococcus faecalis isolates. In this work, a ...

• Sequence diversity of rulA among natural isolates of Pseudomonas syringae and effect on function of rulAB-mediated UV radiation tolerance 

  Sundin, George W.; Jacobs, Janette L.; Murillo Martínez, Jesús  (American Society for Microbiology, 2000)   Artículo / Artikulua  

  The rulAB locus confers tolerance to UV radiation and is borne on plasmids of the pPT23A family in Pseudomonas syringae. We sequenced 14 rulA alleles from P. syringae strains representing seven pathovars and found sequence ...

• Novel blaROB-1-bearing plasmid conferring resistance to β-lactams in Haemophilus parasuis isolates from healthy weaning pigs 

  Moleres Apilluelo, Javier; Santos López, Alfonso; Lázaro, Isidro; Labairu, Javier; Prat, Cristina; Ardanuy, Carmen; González Zorn, Bruno; Aragon, Virginia; Garmendia García, Juncal (American Society for Microbiology, 2015)   Artículo / Artikulua  

  Haemophilus parasuis, the causative agent of Glässer’s disease, is one of the early colonizers of the nasal mucosa of piglets. It is prevalent in swine herds, and lesions associated with disease are fibrinous polyserositis ...

• Analagous population structures for two alphabaculoviruses highlight a functional role for deletion mutants 

  Serrano García, Amaya ; Williams, Trevor ; Simón de Goñi, Oihane; López Ferber, Miguel; Caballero Murillo, Primitivo ; Muñoz, Delia  (American Society for Microbiology, 2012)   Artículo / Artikulua  

  A natural Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV) isolate from Florida shares a strikingly similar genotypic composition to that of a natural Spodoptera frugiperda MNPV (SfMNPV) isolate from Nicaragua. ...

• A Chrysodeixis chalcites single-nucleocapsid nucleopolyhedrovirus population from the Canary Islands is genotypically structured to maximize survival 

  Bernal Rodríguez, Alexandra ; Simón de Goñi, Oihane; Williams, Trevor ; Muñoz, Delia ; Caballero Murillo, Primitivo  (American Society for Microbiology, 2013)   Artículo / Artikulua  

  A Chrysodeixis chalcites single-nucleocapsid nucleopolyhedrovirus wild-type isolate from the Canary Islands, Spain, named ChchSNPV-TF1 (ChchTF1-wt), appears to have great potential as the basis for a biological insecticide ...

• Intra- and intergenerational persistence of an insect nucleopolyhedrovirus: adverse effects of sublethal disease on host development, reproduction, and susceptibility to superinfection 

  Cabodevilla de Andrés, Oihana; Villar, Eduardo; Virto Garayoa, Cristina ; Murillo Pérez, Rosa ; Williams, Trevor ; Caballero Murillo, Primitivo  (American Society for Microbiology, 2011)   Artículo / Artikulua  

  Sublethal infections by Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV) are common in field populations of the beet armyworm (S. exigua, Hübner) in the Almerian horticultural region of Spain. Inoculation of ...

• Increased biofilm formation by nontypeable Haemophilus influenzae isolates from patients with invasive disease or otitis media versus strains recovered from cases of respiratory infections 

  Puig, Carmen ; Domenech, Arnau; Garmendia García, Juncal; Langereis, Jeroen D.; Mayer, Pascal; Calatayud, Laura; Liñares, Josefina; Ardanuy, Carmen; Martí, Sara (American Society for Microbiology, 2014)   Artículo / Artikulua  

  Biofilm formation by nontypeable (NT) Haemophilus influenzae remains a controversial topic. Nevertheless, biofilm-like structures have been observed in the middle-ear mucosa of experimental chinchilla models of otitis media ...

• Stability of a Spodoptera frugiperda nucleopolyhedrovirus deletion recombinant during serial passage in insects 

  Simón de Goñi, Oihane; Williams, Trevor ; Possee, Robert D.; López Ferber, Miguel; Caballero Murillo, Primitivo  (American Society for Microbiology, 2009)   Artículo / Artikulua  

  The stabilities of the Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV) complete genome bacmid (Sfbac) and a deletion recombinant (Sf29null) in which the Sf29 gene was replaced by a kanamycin resistance ...

• Vip3C, a novel class of vegetative insecticidal proteins from Bacillus thuringiensis 

  Palma Dovis, Leopoldo ; Hernández Rodríguez, Carmen Sara; Maeztu Martínez, Mireya; Hernández Martínez, Patricia; Ruiz de Escudero Fuentemilla, Íñigo; Escriche, Baltasar; Muñoz, Delia ; Rie, Jeroen van; Ferré, Juan; Caballero Murillo, Primitivo  (American Society for Microbiology, 2012)   Artículo / Artikulua  

  Three vip3 genes were identified in two Bacillus thuringiensis Spanish collections. Sequence analysis revealed a novel Vip3 protein class (Vip3C). Preliminary bioassays of larvae from 10 different lepidopteran species ...

• A novel binary mixture of Helicoverpa armigera single nucleopolyhedrovirus genotypic variants has improved insecticidal characteristics for control of cotton bollworms 

  Arrizubieta Celaya, Maite ; Simón de Goñi, Oihane; Williams, Trevor ; Caballero Murillo, Primitivo  (American Society for Microbiology, 2015)   Artículo / Artikulua  

  The genotypic diversity of two Spanish isolates of Helicoverpa armigera single nucleopolyhedrovirus (HearSNPV) was evaluated with the aim of identifying mixtures of genotypes with improved insecticidal characteristics for ...

• Relationship between azithromycin susceptibility and administration efficacy for nontypeable Haemophilus influenzae respiratory infection 

  Euba, Begoña; Moleres Apilluelo, Javier; Viadas Martínez, Cristina ; Barberán, Montserrat; Caballero Coronado, Lucía; Grilló Dolset, María Jesús; Bengoechea Alonso, José Antonio; Torres, Juan de; Liñares, Josefina; Leiva, José; Garmendia García, Juncal (American Society for Microbiology, 2015)   Artículo / Artikulua  

  Nontypeable Haemophilus influenzae (NTHI) is an opportunistic pathogen that is an important cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). COPD is an inflammatory disease of the airways, ...

• In vivo monitoring of Staphylococcus aureus biofilm infections and antimicrobial therapy by [18F]fluoro-deoxyglucose–MicroPET in a mouse model 

  Garrido, Victoria ; Collantes, María; Barberán, Montserrat; Peñuelas, Iván; Arbizu, Javier; Amorena Zabalza, Beatriz ; Grilló Dolset, María Jesús (American Society for Microbiology, 2014)   Artículo / Artikulua  

  A mouse model was developed for in vivo monitoring of infection and the effect of antimicrobial treatment against Staphylococcus aureus biofilms, using the [18F]fluoro-deoxyglucose–MicroPET ([18F]FDG-MicroPET) image ...

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