• Noncontiguous operon is a genetic organization for coordinating bacterial gene expression 

  Sáenz Lahoya, S.; Bitarte, Nerea ; Garcia, B.; Burgui Erice, Saioa ; Vergara Irigaray, Marta ; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Toledo Arana, Alejandro ; Lasa Uzcudun, Íñigo  (National Academy of Sciences, 2019)   Artículo / Artikulua  

  Bacterial genes are typically grouped into operons defined as clusters of adjacent genes encoding for proteins that fill related roles and are transcribed into a single polycistronic mRNA molecule. This simple organization ...

• Plastidial phosphoglucose isomerase is an important determinant of seed yield through its involvement in gibberellin-mediated reproductive development and storage reserve biosynthesis in arabidopsis 

  Bahaji, Abdellatif ; Almagro Zabalza, Goizeder ; Ezquer, Ignacio; Gámez Arcas, Samuel ; Sánchez López, Ángela María; Muñoz Pérez, Francisco José ; Barrio, Ramón José; Sampedro, M. Carmen; Diego, Nuria de; Spíchal, Lukás; Dolezal, Karel; Tarkowská, Danuse; Caporali, Elisabetta; Mendes, Marta Adelina; Baroja Fernández, Edurne ; Pozueta Romero, Javier  (American Society of Plant Biologists, 2018)   Artículo / Artikulua  

  The plastid-localized phosphoglucose isomerase isoform PGI1 is an important determinant of growth in Arabidopsis thaliana, likely due to its involvement in the biosynthesis of plastidial isoprenoid-derived hormones. Here, ...

• Molecular signature of aluminum hydroxide adjuvant in ovine PBMCs by integrated mRNA and microRNA transcriptome sequencing 

  Varela Martínez, Endika; Abendaño, Naiara; Asín, Javier; Sistiaga Poveda, Maialen; Pérez, Marta María; Reina Arias, Ramsés ; Andrés Cara, Damián de ; Luján, Lluís; Jugo, Begoña M. (Frontiers Media, 2018)   Artículo / Artikulua  

  There have been few in vivo studies on the effect of aluminum hydroxide adjuvant and its influence on the immune response to vaccination. In this study, lambs received a parallel subcutaneous treatment with either commercial ...

• Expression analysis of lung miRNAs responding to ovine VM virus infection by RNA-seq 

  Bilbao Arribas, Martin; Abendaño, Naiara; Varela Martínez, Endika; Reina Arias, Ramsés ; Andrés Cara, Damián de ; Jugo, Begoña M. (BioMed Central, 2019)   Artículo / Artikulua  

  Background: MicroRNAs (miRNAs) are short endogenous, single-stranded, noncoding small RNA molecules of approximately 22 nucleotides in length. They regulate gene expression posttranscriptionally by silencing mRNA expression, ...

• Proteomics analysis reveals non-controlled activation of photosynthesis and protein synthesis in a rice npp1 mutant under high temperature and elevated CO2 conditions 

  Inomata, Takuya; Baslam, Marouane ; Masui, Takahiro; Koshu, Tsutomu; Takamatsu, Takeshi; Kaneko, Kentaro; Pozueta Romero, Javier ; Mitsui, Toshiaki (MDPI, 2018)   Artículo / Artikulua  

  Rice nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) catalyzes the hydrolytic breakdown of the pyrophosphate and phosphodiester bonds of a number of nucleotides including ADP-glucose and ATP. Under high temperature ...

• Antagonistic pleiotropy in the bifunctional surface protein fadl (OmpP1) during adaptation of Haemophilus influenzae to chronic lung infection associated with chronic obstructive pulmonary disease 

  Moleres Apilluelo, Javier ; Fernández Calvet, Ariadna ; Ehrlich, Rachel L.; Martí, Sara; Pérez Regidor, Lucía; Euba, Begoña; Rodríguez Arce, Irene ; Balashov, Sergey; Cuevas, Ester; Liñares, Josefina; Ardanuy, Carmen; Martín Santamaría, Sonsoles; Ehrlich, Garth D.; Mell, Joshua Chang; Garmendia, Junkal (American Society for Microbiology, 2018)   Artículo / Artikulua  

  Tracking bacterial evolution during chronic infection provides insights into how host selection pressures shape bacterial genomes. The human-restricted opportunistic pathogen nontypeable Haemophilus influenzae (NTHi) infects ...

• A cAMP/CRP-controlled mechanism for the incorporation of extracellular ADP-glucose in Escherichia coli involving NupC and NupG nucleoside transporters 

  Almagro Zabalza, Goizeder ; Viale, Alejandro M. ; Montero Macarro, Manuel ; Muñoz Pérez, Francisco José ; Baroja Fernández, Edurne ; Mori, Hirotada; Pozueta Romero, Javier  (Nature Research, 2018)   Artículo / Artikulua  

  ADP-glucose is the precursor of glycogen biosynthesis in bacteria, and a compound abundant in the starchy plant organs ingested by many mammals. Here we show that the enteric species Escherichia coli is capable of scavenging ...

• Volatile compounds emitted by diverse phytopathogenic microorganisms promote plant growth and flowering through cytokinin action 

  Sánchez López, Ángela María; Baslam, Marouane ; Muñoz Pérez, Francisco José ; Bahaji, Abdellatif ; Almagro Zabalza, Goizeder ; Ricarte Bermejo, Adriana ; García-Gómez, Pablo; Baroja Fernández, Edurne ; Pozueta Romero, Javier  (John Wiley & Sons, 2016)   Artículo / Artikulua  

  It is known that volatile emissions from some beneficial rhizosphere microorganisms promote plant growth. Here we show that volatile compounds (VCs) emitted by phylogenetically diverse rhizosphere and non-rhizhosphere ...

• Arabidopsis responds to Alternaria alternata volatiles by triggering pPG-independent mechanisms 

  Sánchez López, Ángela María; Bahaji, Abdellatif ; Diego, Nuria de; Baslam, Marouane ; Li, Jun ; Muñoz Pérez, Francisco José ; Almagro Zabalza, Goizeder ; García-Gómez, Pablo; Ameztoy del Amo, Kinia ; Ricarte Bermejo, Adriana ; Novák, Ondrej; Humplik, Jan F.; Spíchal, Lukás; Dolezal, Karel; Ciordia, Sergio; Mena, María Carmen; Navajas, Rosana; Baroja Fernández, Edurne ; Pozueta Romero, Javier  (American Society of Plant Biologists, 2016)   Artículo / Artikulua  

  Volatile compounds (VCs) emitted by phylogenetically diverse microorganisms (including plant pathogens and microbes that do not normally interact mutualistically with plants) promote photosynthesis, growth, and the ...

• Binding of Bacillus thuringiensis subsp. israelensis Cry4Ba to Cyt1Aa has an important role in synergism 

  Cantón, Pablo Emiliano; Zanicthe Reyes, Esmeralda; Ruiz de Escudero Fuentemilla, Íñigo ; Bravo, Alejandra; Soberón, Mario (Elsevier, 2011)   Artículo / Artikulua  

  Bacillus thuringiensis subsp. israelensis (Bti) produces at least four different crystal proteins that are specifically toxic to different mosquito species and that belong to two non-related family of toxins, Cry and ...

• Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands 

  Tormo Más, María Ángeles; Mir, Ignacio; Shrestha, Archana; Tallent, Sandra M.; Campoy Sánchez, Susana; Lasa Uzcudun, Íñigo ; Barbé, Jordi; Novick, Richard P.; Christie, Gail E.; Penadés, José R. (Nature Research, 2010)   Artículo / Artikulua  

  Staphylococcal superantigen-carrying pathogenicity islands (SaPIs) are discrete, chromosomally integrated units of ∼15 kilobases that are induced by helper phages to excise and replicate. SaPI DNA is then efficiently ...

• The amino- and carboxyl-terminal fragments of the Bacillus thuringensis Cyt1Aa toxin have differential roles on toxin oligomerization and pore formation 

  Rodríguez Almazán, Claudia; Ruiz de Escudero Fuentemilla, Íñigo ; Cantón, Pablo Emiliano; Muñoz Garay, Carlos; Pérez, Claudia; Gill, Sarjeet S.; Soberón, Mario; Bravo, Alejandra (American Chemical Society, 2011)   Artículo / Artikulua  

  The Cyt toxins produced by the bacteria Bacillus thuringiensis show insecticidal activity against some insects, mainly dipteran larvae, being able to kill mosquitoes and black flies. However, they also possess a general ...

• Near-infrared fluorescence imaging as an alternative to bioluminescent bacteria to monitor biomaterial-associated infections 

  Dinjaski, Nina; Shalu, Suri; Valle Turrillas, Jaione ; Lehman, Susan M.; Lasa Uzcudun, Íñigo ; Prieto, María Auxiliadora; García, Andrés J. (Elsevier, 2014)   Artículo / Artikulua  

  Biomaterial-associated infection is one of the most common complications related with the implantation of any biomedical device. Several in vivo imaging platforms have emerged as powerful diagnostic tools to longitudinally ...

• Overexpression of thioredoxin m in tobacco chloroplasts inhibits the protein kinase STN7 and alters photosynthetic performance 

  Ancín Rípodas, María ; Fernández San Millán, Alicia ; Larraya Reta, Luis María ; Morales Iribas, Fermín; Veramendi Charola, Jon ; Aranjuelo Michelena, Iker; Farrán Blanch, Inmaculada  (Oxford University Press, 2019)   Artículo / Artikulua  

  The activity of the protein kinase STN7, involved in phosphorylation of the light-harvesting complex II (LHCII) proteins, has been reported as being co-operatively regulated by the redox state of the plastoquinone pool ...

• Calcium inhibits bap-dependent multicellular behavior in Staphylococcus aureus 

  Arrizubieta Balerdi, María Jesús ; Toledo Arana, Alejandro ; Amorena Zabalza, Beatriz ; Penadés, José R.; Lasa Uzcudun, Íñigo  (American Society for Microbiology, 2004)   Artículo / Artikulua  

  Bap (biofilm-associated protein) is a 254-kDa staphylococcal surface protein implicated in formation of biofilms by staphylococci isolated from chronic mastitis infections. The presence of potential EF-hand motifs in the ...

• Bap, a Staphylococcus aureus surface protein involved in biofilm formation 

  Cucarella, Carme; Solano Goñi, Cristina ; Valle Turrillas, Jaione ; Amorena Zabalza, Beatriz ; Lasa Uzcudun, Íñigo ; Penadés, José R. (American Society for Microbiology, 2001)   Artículo / Artikulua  

  Identification of new genes involved in biofilm formation is needed to understand the molecular basis of strain variation and the pathogenic mechanisms implicated in chronic staphylococcal infections. A biofilm-producing ...

• Conditional mutation of an essential putative glycoprotease eliminates autolysis in Staphylococcus aureus 

  Zheng, L.; Yu, C.; Bayles, K.; Lasa Uzcudun, Íñigo ; Ji, Y. (American Society for Microbiology, 2007)   Artículo / Artikulua  

  Our previous studies demonstrated that a putative Staphylococcus aureus glycoprotease (Gcp) is essential for bacterial survival, indicating that Gcp may be a novel target for developing antibacterial agents. However, the ...

• B regulates IS256-mediated Staphylococcus aureus biofilm phenotypic variation 

  Valle Turrillas, Jaione ; Vergara Irigaray, Marta ; Merino, Nekane ; Penadés, José R.; Lasa Uzcudun, Íñigo  (American Society for Microbiology, 2007)   Artículo / Artikulua  

  Biofilm formation in Staphylococcus aureus is subject to phase variation, and biofilm-negative derivatives emerge sporadically from a biofilm-positive bacterial population. To date, the only known mechanism for generating ...

• Glycogen phosphorylase, the product of the glgP Gene, catalyzes glycogen breakdown by removing glucose units from the nonreducing ends in Escherichia coli 

  Alonso Casajús, Nora ; Dauvillee, David; Viale, Alejandro M. ; Muñoz Pérez, Francisco José ; Baroja Fernández, Edurne ; Morán Zorzano, María Teresa ; Eydallin, Gustavo ; Ball, Steven; Pozueta Romero, Javier  (American Society for Microbiology, 2006)   Artículo / Artikulua  

  To understand the biological function of bacterial glycogen phosphorylase (GlgP), we have produced and characterized Escherichia coli cells with null or altered glgP expression. glgP deletion mutants (ΔglgP) totally lacked ...

• Staphylococcus aureus pathogenicity island DNA is packaged in particles composed of phage proteins 

  Tormo Más, María Ángeles; Ferrer, María Desamparados; Maiques, Elisa; Ubeda, Carles; Selva, Laura; Lasa Uzcudun, Íñigo ; Calvete, Juan J.; Novick, Richard P.; Penadés, José R. (American Society for Microbiology, 2008)   Artículo / Artikulua  

  Staphylococcus aureus pathogenicity islands (SaPIs) have an intimate relationship with temperate staphylococcal phages. During phage growth, SaPIs are induced to replicate and are efficiently encapsidated into special small ...

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