Morphological and biochemical characterization of a cell death process induced by E3, a new synthetic diarylsulfonilurea analogue

Abstract

With a view to finding new compounds with improved antitumoral activity and reduced secondary effects, our group, using theoretical structure-activity studies, has designed several analogues and derivatives of diarylsulfonilureas. These compounds have been synthesized and tested “in vitro” on a panel of human tumor cell lines and showed an antitumoral activity. In the present work, we have characterized the mechanisms involved in the cell death process induced by one of these products called E3 in a CCRF-CEM cell line.