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dc.creatorGarrido, Victoriaes_ES
dc.creatorCollantes, Maríaes_ES
dc.creatorBarberán, Montserrates_ES
dc.creatorPeñuelas, Ivánes_ES
dc.creatorArbizu, Javieres_ES
dc.creatorAmorena Zabalza, Beatrizes_ES
dc.creatorGrilló Dolset, María Jesúses_ES
dc.date.accessioned2019-01-10T08:27:51Z
dc.date.available2019-01-10T08:27:51Z
dc.date.issued2014
dc.identifier.issn0066-4804 (Print)
dc.identifier.issn1098-6596 (Electronic)
dc.identifier.urihttps://hdl.handle.net/2454/31929
dc.description.abstractA mouse model was developed for in vivo monitoring of infection and the effect of antimicrobial treatment against Staphylococcus aureus biofilms, using the [18F]fluoro-deoxyglucose–MicroPET ([18F]FDG-MicroPET) image technique. In the model, sealed Vialon catheters were briefly precolonized with S. aureus strains ATCC 15981 or V329, which differ in cytotoxic properties and biofilm matrix composition. After subcutaneous implantation of catheters in mice, the S. aureus strain differences found in bacterial counts and the inflammatory reaction triggered were detected by the regular bacteriological and histological procedures and also by [18F]FDG-MicroPET image signal intensity determinations in the infection area and regional lymph node. Moreover, [18F]FDG-MicroPET imaging allowed the monitoring of the rifampin treatment effect, identifying the periods of controlled infection and those of reactivated infection due to the appearance of bacteria naturally resistant to rifampin. Overall, the mouse model developed may be useful for noninvasive in vivo determinations in studies on S. aureus biofilm infections and assessment of new therapeutic approaches.en
dc.description.sponsorshipThis work was supported by grants from Gobierno de Navarra “IIM13002.RI1” and MICINN “CIT-010000-2009-32”.en
dc.format.extent8 p.
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherAmerican Society for Microbiologyen
dc.relation.ispartofAntimicrobial Agents and Chemotherapy, Nov 2014, 58 (11) 6660-6667en
dc.rights© 2014, American Society for Microbiology. All Rights Reserved.en
dc.subjectStaphylococcus aureus biofilm infectionsen
dc.subject[18F]fluoro-deoxyglucose–MicroPETen
dc.titleIn vivo monitoring of Staphylococcus aureus biofilm infections and antimicrobial therapy by [18F]fluoro-deoxyglucose–MicroPET in a mouse modelen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentUniversidad Pública de Navarra. Instituto de Agrobiotecnologíaes_ES
dc.contributor.departmentNafarroako Unibertsitate Publikoa. Agrobioteknologiako Institutuaeu
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.identifier.doi10.1128/aac.03138-14
dc.relation.publisherversionhttps://doi.org/10.1128/aac.03138-14
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua, IIM13002.RI1es


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