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Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus
dc.creator | Maiques, Elisa | es_ES |
dc.creator | Ubeda, Carles | es_ES |
dc.creator | Campoy Sánchez, Susana | es_ES |
dc.creator | Salvador, Noelia | es_ES |
dc.creator | Lasa Uzcudun, Íñigo | es_ES |
dc.creator | Novick, Richard P. | es_ES |
dc.creator | Barbé, Jordi | es_ES |
dc.creator | Penadés, José R. | es_ES |
dc.date.accessioned | 2019-01-21T13:24:45Z | |
dc.date.available | 2019-01-21T13:24:45Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 0021-9193 (Print) | |
dc.identifier.issn | 1098-5530 (Electronic) | |
dc.identifier.uri | https://hdl.handle.net/2454/32031 | |
dc.description.abstract | Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer of pathogenicity island-encoded virulence factors. Here we report that β-lactams induce a bona fide SOS response in S. aureus, characterized by the activation of the RecA and LexA proteins, the two master regulators of the SOS response. Moreover, we show that β-lactams are capable of triggering staphylococcal prophage induction in S. aureus lysogens. Consequently, and as previously described for SOS induction by commonly used fluoroquinolone antibiotics, β-lactam-mediated phage induction also resulted in replication and high-frequency transfer of the staphylococcal pathogenicity islands, showing that such antibiotics may have the unintended consequence of promoting the spread of bacterial virulence factors. | en |
dc.description.sponsorship | This work was supported by grants BIO2002-04542-C02-01 and BIO2005-08399-C02-02 from the Comisión Interministerial de Ciencia y Tecnología (C.I.C.Y.T.), grants from the Cardenal Herrera-CEU University, the Conselleria de Agricultura, Pesca i Alimentació (CAPiA), and the Generalitat Valenciana (CTIDIA/2002/62, CTESPP/2003/027, and AE04-8) to J.R.P., and a grant from the MEC (AGL2005-03574/GAN) to J.B. Fellowship support for C.U. from CAPiA and for E.M. from the Cardenal Herrera-CEU University is gratefully acknowledged. | en |
dc.format.extent | 4 p. | |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | American Society for Microbiology | en |
dc.relation.ispartof | Journal of Bacteriology, Apr. 2006, Vol. 188, No. 7, p. 2726–2729 | en |
dc.rights | © 2006, American Society for Microbiology. All Rights Reserved. | en |
dc.subject | Beta-lactams | en |
dc.subject | Staphylococcus aureus | en |
dc.subject | SOS response | en |
dc.subject | Horizontal transfer | en |
dc.subject | Virulence factors | en |
dc.title | Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus | en |
dc.title.alternative | β-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus | en |
dc.type | info:eu-repo/semantics/article | en |
dc.type | Artículo / Artikulua | es |
dc.contributor.department | IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
dc.identifier.doi | 10.1128/jb.188.7.2726-2729.2006 | |
dc.relation.publisherversion | https://doi.org/10.1128/jb.188.7.2726-2729.2006 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.type.version | Versión publicada / Argitaratu den bertsioa | es |