Listar por autor UPNA "Rotinen Díaz, Mirja Sofia"
Mostrando ítems 1-6 de 6
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Actionable driver events in small cell lung cancer
Small cell lung cancer (SCLC) stands out as the most aggressive form of lung cancer, characterized by an extremely high proliferation rate and a very poor prognosis, with a 5-year survival rate that falls below 7%. ... -
Changes in gene expression profiling of apoptotic genes in neuroblastoma cell lines upon retinoic acid treatment
To determine the effect of retinoic acid (RA) in neuroblastoma we treated RA sensitive neuroblastoma cell lines with 9-cis RA or ATRA for 9 days, or for 5 days followed by absence of RA for another 4 days. Both isomers ... -
Cutting down on lung cancer: Ecliptasaponin A is a novel therapeutic agent
This article is a comment of 'Han J, Lv W, Sheng H, et al. Ecliptasaponin A induces apoptosis through the activation of ASK1/JNK pathway and autophagy in human lung cancer cells. Ann Transl Med 2019;7:539'. -
'Defining the independence of the liver circadian clock' & 'BMAL1-driven tissue clocks respond independently to light to maintain homeostasis'
These studies demonstrate that peripheral tissues and organs can detect changes in environmental light and are capable of maintaining some basic functions, independently from our brain clock. The liver can autonomously ... -
Scaffold attachment factor B1 regulates androgen degradation pathways in prostate cancer
The nuclear matrix protein Scaffold Attachment Factor B1 (SAFB1, SAFB) can act in prostate cancer (PCa) as an androgen receptor (AR) co-repressor that functions through epigenetic silencing of AR targets, such as prostate ... -
Transcriptional regulation of type 11 17β-hydroxysteroid dehydrogenase expression in prostate cancer cells
Type 11 Hydroxysteroid (17-beta) dehydrogenase (HSD17B11) catalyzes the conversion of 5α-androstan-3α,17β-diol into androsterone suggesting that it may play an important role in androgen metabolism. We previously described ...