Listar por autor "Pérez Mediavilla, Alberto"
Mostrando ítems 1-4 de 4
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Early-onset molecular derangements in the olfactory bulb of Tg2576 mice: novel insights into the stress-responsive olfactory kinase dynamics in Alzheimer’s disease
Lachén Montes, Mercedes ; González Morales, Andrea ; Palomino Alonso, Maialen; Ausín, Karina; Gómez-Ochoa, Marta; Zelaya Huerta, María Victoria ; Ferrer, Isidro; Pérez Mediavilla, Alberto; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (Frontiers Media, 2019) Artículo / ArtikuluaThe olfactory bulb (OB) is the first processing station in the olfactory pathway. Despite smell impairment, which is considered an early event in Alzheimer’s disease (AD), little is known about the initial molecular ... -
Network-driven proteogenomics unveils an aging-related imbalance in the olfactory IκBα-NFκB p65 complex functionality in Tg2576 Alzheimer’s disease mouse model
Palomino Alonso, Maialen; Lachén Montes, Mercedes ; González Morales, Andrea ; Ausín, Karina; Pérez Mediavilla, Alberto; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (MDPI, 2017) Artículo / ArtikuluaOlfaction is often deregulated in Alzheimer’s disease (AD) patients, and is also impaired in transgenic Tg2576 AD mice, which overexpress the Swedish mutated form of human amyloid precursor protein (APP). However, little ... -
Smelling the dark proteome: functional characterization of PITH domain-containing protein 1 (C1orf128) in olfactory metabolism
Lachén Montes, Mercedes ; Mendizuri, Naroa; Ausín, Karina; Pérez Mediavilla, Alberto; Azkargorta, Mikel; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Iloro, Ibon; Elortza, Félix; Kondo, Hiroyuki; Ohigashi, Izumi; Ferrer, Isidro; Torre, Rafael de la; Robledo, Patricia (ACS Publications, 2020) Artículo / ArtikuluaThe Human Proteome Project (HPP) consortium aims to functionally characterize the dark proteome. On the basis of the relevance of olfaction in early neurodegeneration, we have analyzed the dark proteome using data mining ... -
Stabilization of 14-3-3 protein-protein interactions with Fusicoccin-A decreases alpha-synuclein dependent cell-autonomous death in neuronal and mouse models
Vinueza-Gavilanes, Rodrigo; Bravo-González, Jorge Juan; Basurco, Leyre; Boncristiani, Chiara; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Marcilla, Irene; Pérez Mediavilla, Alberto; Luquin, María Rosario; Vales, Africa; González-Aseguinolaza, Gloria; Aymerich, María Soledad; Aragón, Tomás; Arrasate, Montserrat (Elsevier, 2023) Artículo / ArtikuluaSynucleinopathies are a group of neurodegenerative diseases without effective treatment characterized by the abnormal aggregation of alpha-synuclein (aSyn) protein. Changes in levels or in the amino acid sequence of aSyn ...