• Association of blood-based DNA methylation markers with late-onset alzheimer disease: a potential diagnostic approach 

  Acha Santamaría, Blanca  ; Corroza, Jon; Sánchez Ruiz de Gordoa, Javier  ; Cabello, Carolina; Robles Solano, Maitane; Méndez López, Iván  ; Macías, Mónica; Zueco, Sara; Roldán, Miren; Urdánoz Casado, Amaya  ; Jericó Pascual, Ivonne; Erro Aguirre, María Elena; Alcolea, Daniel; Lleo, Alberto; Blanco Luquin, Idoia; Mendióroz Iriarte, Maite (Lippincott Williams & WilkinsAmerican Academy of Neurology, 2023)   Artículo / Artikulua  

  Background and Objectives: There is an urgent need to identify novel noninvasive biomarkers for Alzheimer disease (AD) diagnosis. Recent advances in blood-based measurements of phosphorylated tau (pTau) species are promising ...

• Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences 

  Berasain, Carmen; Goñi Irigoyen, Saioa  ; Castillo, Josefa; Latasa, Maria Ujue; Prieto, Jesús; Ávila, Matías A (Baishideng Publishing Group, 2010)   Artículo / Artikulua  

  Pre-mRNA splicing is an essential step in the process of gene expression in eukaryotes and consists of the removal of introns and the linking of exons to generate mature mRNAs. This is a highly regulated mechanism that ...

• Influence of diabetes mellitus on the pathological profile of aortic stenosis: a sex-based approach 

  Martín Núñez, Ernesto; Goñi Olóriz, Miriam; Matilla Cuenca, Lara; Garaikoetxea Zubillaga, Mattie; Mourino-Álvarez, Laura; Navarro, Adela; Fernández Celis, Amaya; Tamayo Rodríguez, Ibai; Gaínza Calleja, Alicia; Álvarez, Virginia; Sádaba Sagredo, Rafael; Barderas, María G.; Jover, Eva; López Andrés, Natalia (Springer Nature, 2023)   Artículo / Artikulua  

  Background: Diabetes mellitus (DM) accelerates the progression of aortic stenosis (AS), but how their underlying molecular mechanisms interact is not clear. Moreover, whether DM contributes to clinically relevant sex-differences ...

• Intra-assessment resting metabolic rate variability is associated with cardiometabolic risk factors in middle-aged adults 

  Alcántara Alcántara, Juan Manuel; Osuna Prieto, Francisco J.; Castillo, Manuel J.; Plaza Florido, Abel; Amaro Gahete, Francisco J. (MDPI, 2023)   Artículo / Artikulua  

  The intra-assessment resting metabolic rate variability is related to cardiometabolic health, as suggested by previous literature. We studied whether that variability (expressed as coefficient of variation [CV; %]) for ...

• Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα 

  Liang, Ning; Damdimopoulos, Anastasius; Goñi Irigoyen, Saioa  ; Huang, Zhiqiang; Vedin, Lise-Lotte; Jakobsson, Tomas; Giudici, Marco; Ahmed, Osman; Pedrelli, Matteo; Barilla, Serena; Alzaid, Fawaz; Mendoza, Arturo; Schröder, Tarja; Kuiper, Raoul; Parini, Paolo; Hollenberg, Anthony; Lefebvre, Philippe; Francque, Sven; Van Gaal, Luc; Staels, Bart; Venteclef, Nicolas; Treuter, Eckardt; Fan, Rongrong (Nature Research, 2019)   Artículo / Artikulua  

  Obesity triggers the development of non-alcoholic fatty liver disease (NAFLD), which involves alterations of regulatory transcription networks and epigenomes in hepatocytes. Here we demonstrate that G protein pathway ...

• Impaired LXRα phosphorylation attenuates progression of fatty liver disease 

  Bécares, Natalia; Gage, Matthew C.; Voisin, Maud; Shrestha, Elina; Martín-Gutiérrez, Lucía; Liang, Ning; Louie, Rikah; Pourcet, Benoît; Pello, Óscar M.; Luong, Tu Vinh; Goñi Irigoyen, Saioa  ; Pichardo-Almarza, César; Røberg-Larsen, Hanne; Díaz-Zuccarini, Vanessa; Steffensen, Knut R.; O’Brien, Alastair; Garabedian, Michael J.; Rombouts, Krista; Treuter, Eckardt; Pineda-Torra, Inés (Cell Press, 2019)   Artículo / Artikulua  

  Non-alcoholic fatty liver disease (NAFLD) is a very common indication for liver transplantation. How fat-rich diets promote progression from fatty liver to more damaging inflammatory and fibrotic stages is poorly understood. ...

• Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer 

  Macaya, Irati; Roman, Marta; Welch, Connor; Entrialgo-Cadierno, Rodrigo; Salmon, Marina; Santos, Alba; Feliu, Iker; Kovalski, Joanna; López Erdozain, Inés; Rodríguez-Remírez, María; Palomino Echeverría, Sara  ; Lonfgren, Shane M.; Ferrero, Macarena; Calabuig, Silvia; Ludwig, Iziar A.; Lara-Astiaso, David; Jantus-Lewintre, Eloisa; Guruceaga, Elizabeth; Narayanan, Shruthi; Ponz Sarvisé, Mariano; Pineda Lucena, Antonio; Lecanda, Fernando; Ruggero, Davide; Khatri, Purvesh; Santamaría, Enrique; Fernández Irigoyen, Joaquín  ; Ferrer, Irene; Paz-Ares, Luis; Drosten, Matthias; Barbacid, Mariano; Gil-Bazo, Ignacio; Vicent, Silvestre (Springer Nature, 2023)   Artículo / Artikulua  

  Drug combinations are key to circumvent resistance mechanisms compromising response to single anti-cancer targeted therapies. The implementation of combinatorial approaches involving MEK1/2 or KRASG12C inhibitors in the ...

• 20-Year trajectories of six psychopathological dimensions in patients with first-episode psychosis: could they be predicted? 

  Cuesta, Manuel J.; Gil Berrozpe, Gustavo José; Sánchez Torres, Ana María  ; Moreno-Izco, Lucía; García de Jalón, Elena; Peralta Martín, Víctor; SEGPEPs Group (Elsevier, 2024)   Artículo / Artikulua

  Patients with first-episode psychoses (FEP) exhibit heterogeneity in clinical manifestations and outcomes. This study investigated the long-term trajectories of six key psychopathological dimensions (reality-distortion, ...

• Sex-specific dose-response effects of a 24-week supervised concurrent exercise intervention on cardiorespiratory fitness and muscular strength in young adults: The ACTIBATE randomized controlled trial 

  Camacho-Cardenosa, Alba; Amaro Gahete, Francisco J.; Martínez Téllez, Borja; Alcántara Alcántara, Juan Manuel; Ortega, Francisco B.; Ruiz, Jonatan R. (Wiley, 2024)   Artículo / Artikulua  

  Concurrent training has been postulated as an appropriate time-efficient strategy to improve physical fitness, yet whether the exercise-induced adaptations are similar in men and women is unknown. An unblinded randomized ...

• Peaking for the world para athletics championships: case study of a world champion female paralympic shot putter 

  Garcia-Carrillo, Exal; Ramírez Campillo, Rodrigo (Universidad de Alicante, 2020)   Contribución a congreso / Biltzarrerako ekarpena  

  Tapering is used to maximize performance and reduce fatigue levels before athletic competitions. However, scientific evidence regarding Paralympic athletes is scarce. Moreover, no study has assessed the effects of tapering ...

• Evaluation of physical fitness in track and field throwing athletes across different competitive levels 

  Garcia-Carrillo, Exal; Gallardo Fuentes, Francisco; Ramírez Campillo, Rodrigo; Carter-Thuillier, Bastian; Thapa, Rohit Kumar; Zaras, Nikolaos (Cherkas Global University Press, 2024)   Artículo / Artikulua  

  A comprehensive understanding of physical fitness across different competitive levels is essential in track and field athletics. Coaches of throwers typically develop training regimens tailored to either performance ...

• Evaluación de la eficacia de la intervención con adolescentes en situación de riesgo en un programa de prevención indicada 

  Mendigutxia Sorabilla, Garikoitz (2024)   Tesis doctoral / Doktoretza tesia  

  El objetivo general de esta investigación es evaluar la eficacia de la intervención realizada con los adolescentes que acuden al programa de prevención indicada Suspertu. Con el propósito de lograr este objetivo general, ...

• Delirium en el adulto mayor: de los biomarcadores a la práctica clínica 

  Lozano Vicario, Lucía (2024)   Tesis doctoral / Doktoretza tesia  

  La presente tesis doctoral gira en torno al potencial uso de los biomarcadores para predecir delirium en los adultos mayores y el uso de ejercicio físico como herramienta para modificar la evolución de éste una vez instaurado. ...

• Isolation of Lactic Acid Bacteria (LAB) from salmonids for potential use as probiotics: in vitro assays and toxicity assessment of salmo trutta embryonated eggs 

  Vargas González, Augusto  ; Barajas Vélez, Miguel Ángel  ; Pérez Sánchez, Tania   (MDPI, 2024)   Artículo / Artikulua  

  This research investigates the potential of lactic acid bacteria (LAB) from freshwater salmonids as prospective probiotics for application in aquaculture. LAB and pathogenic bacteria were obtained from mucus and tissues ...

• Intentos de suicidio en personas mayores en servicios de urgencias psiquiátricas 

  Yárnoz-Goñi, Nora; López-Goñi, José Javier  ; Goñi-Sarriés, Adriana (Ministerio de Sanidad y Consumo, 2023)   Artículo / Artikulua  

  FUNDAMENTOS. En las personas mayores hay una alta prevalencia de trastorno mental, baja demanda asistencial y mayor riesgo de conducta suicida. La atención en Urgencias psiquiátricas puede ser la puerta de acceso a los ...

• Effect of polygenic risk score, family load of schizophrenia and exposome risk score, and their interactions, on the long-term outcome of first-episode psychosis 

  Cuesta, Manuel J.; Papiol, S.; Ibáñez Beroiz, B.  ; García de Jalón, Elena; Sánchez Torres, Ana María  ; Gil Berrozpe, Gustavo José; Moreno-Izco, Lucía; Zarzuela, Amalia; Fañanás, Lourdes; Peralta Martín, Víctor; SEGPEPs Group (Cambridge University Press, 2023)   Artículo / Artikulua  

  Background. Consistent evidence supports the involvement of genetic and environmental factors, and their interactions, in the etiology of psychosis. First-episode psychosis (FEP) comprises a group of disorders that show ...

• El comienzo de la lactancia: experiencias de madres primerizas 

  Belintxon, Maider; Zaragüeta, M. C.; Adrián, M. C.; López de Dicastillo Sáinz de Murieta, Olga   (Gobierno de Navarra, 2011)   Artículo / Artikulua  

  Fundamento. La lactancia materna es importante para promover el desarrollo saludable del recién nacido. A pesar de sus beneficios, el abandono es masivo durante el primer trimestre de vida. El objetivo de esta investigación ...

• Health professionals' personal behaviours hindering health promotion: a study of nurses who smoke 

  Mujika Zabaleta,  Agurtzane; Arantzamendi, María; López de Dicastillo Sáinz de Murieta, Olga  ; Forbes, Angus (Wiley, 2017)   Artículo / Artikulua  

  Aim: To explore the views of current and ex-smoker nurses on their role in sup-porting patients to stop smoking. Background: Long-term conditions are closely linked to harmful lifestyle behaviours, including smoking and ...

• Los retos de la promoción de la salud en una sociedad multicultural: revisión narrativa de la literatura 

  Belintxon, Maider; López de Dicastillo Sáinz de Murieta, Olga   (Gobierno de Navarra, 2014)   Artículo / Artikulua  

  La realidad multicultural en la que vivimos hoy en día, hace que los profesionales de la salud interactúen a diario con personas y familias de culturas diversas. La interacción entre una persona o familia y un profesional ...

• Oleuropein-driven reprogramming of the myeloid cell compartment to sensitise tumours to PD-1/PD-L1 blockade strategies 

  Blanco, Ester; Silva-Pilipich, Noelia; Bocanegra Gondán, Ana Isabel; Chocarro, Luisa  ; Procopio, Antonio; Ausín, Karina; Fernández Irigoyen, Joaquín  ; Fernández Rubio, Leticia; Razquin, Nerea; Igea, Ana; Garnica, Maider; Echaide Górriz, Míriam; Arasanz Esteban, Hugo; Vera García, Ruth; Escors Murugarren, David; Smerdou, Cristian; Kochan, Grazyna (Springer Nature, 2024)   Artículo / Artikulua  

  Background: Previous studies have shown that functional systemic immunity is required for the efficacy of PD-1/PD-L1 blockade immunotherapies in cancer. Hence, systemic reprogramming of immunosuppressive dysfunctional ...

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