Experimental and theoretical studies of the interaction of ketoprofen in halloysite nanotubes
Fecha
2021Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión aceptada / Onetsi den bertsioa
Impacto
|
10.1016/j.colsurfa.2021.127136
Resumen
In recent years, the application of halloysite (HAL) in the conception of drug systems has become important due to its excellent physicochemical properties. Ketoprofen (KET) is widely used around the world as an anti-inflammatory drug. A formulation of HAL-KET was prepared. The interaction between the KET molecules and HAL has been investigated experimentally by Zeta potential, TEM, XRD, FTIR spe ...
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In recent years, the application of halloysite (HAL) in the conception of drug systems has become important due to its excellent physicochemical properties. Ketoprofen (KET) is widely used around the world as an anti-inflammatory drug. A formulation of HAL-KET was prepared. The interaction between the KET molecules and HAL has been investigated experimentally by Zeta potential, TEM, XRD, FTIR spectroscopy and TGA/DSC. In addition, this interaction was studied theoretically by using Monte-Carlo calculation method (MC). The results have shown that the interaction of KET is stabilized not only by electrostatic interactions and hydrogen bonds with HAL but also via the delocalized π electrons density of phenyl groups of KET and the hydrogen atoms of HAL. [--]
Materias
Characterization,
Halloysite,
Interaction,
Ketoprofen,
Molecular modeling,
Pharmaceutical carrier
Editor
Elsevier
Publicado en
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 627, 20 October 2021, 127136
Departamento
Universidad Pública de Navarra. Departamento de Ciencias /
Nafarroako Unibertsitate Publikoa. Zientziak Saila /
Universidad Pública de Navarra/Nafarroako Unibertsitate Publikoa. Institute for Advanced Materials and Mathematics - INAMAT2
Versión del editor
Entidades Financiadoras
This work was financially supported by la direction générale de la recherche scientifique (Algeria), le laboratoire de génie des procédés chimiques (LGPC) et le laboratoire des matériaux émergeants de l'université de Sétif 1. A.G also thanks Santander Bank (Navarra, Spain) for funding via the Research Intensification Program.