Steering the synthesis of Fe3O4 nanoparticles under sonication by using a fractional factorial design
Fecha
2021Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión aceptada / Onetsi den bertsioa
Impacto
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10.1016/j.matchemphys.2021.124760
Resumen
Superparamagnetic iron oxide nanoparticles (MNPs) have the potential to act as heat sources in magnetic hyperthermia. The key parameter for this application is the specific absorption rate (SAR), which must be as large as possible in order to optimize the hyperthermia treatment. We applied a Plackett-Burman fractional factorial design to investigate the effect of total iron concentration, ammonia ...
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Superparamagnetic iron oxide nanoparticles (MNPs) have the potential to act as heat sources in magnetic hyperthermia. The key parameter for this application is the specific absorption rate (SAR), which must be as large as possible in order to optimize the hyperthermia treatment. We applied a Plackett-Burman fractional factorial design to investigate the effect of total iron concentration, ammonia concentration, reaction temperature, sonication time and percentage of ethanol in the aqueous media on the properties of iron oxide MNPs. Characterization techniques included total iron content, Fourier Transform Infrared Spectroscopy, X-Ray Diffraction, High Resolution Transmission Electron Microscopy, and Dynamic Magnetization. The reaction pathway in the coprecipitation reaction depended on the initial Fe concentration. Samples synthesized from 0.220 mol L−1 Fe yielded magnetite and metastable precipitates of iron oxyhydroxides. An initial solution made up of 0.110 mol L−1 total Fe and either 0.90 or 1.20 mol L−1 NH3(aq) led to the formation of magnetite nanoparticles. Sonication of the reaction media promoted a phase transformation of metastable oxyhydroxides to crystalline magnetite, the development of crystallinity, and the increase of specific absorption rate under dynamic magnetization. [--]
Materias
Fractional factorial design,
Magnetite nanoparticles,
Phase transformation,
Sonication,
Specific absorption rate
Editor
Elsevier
Publicado en
Materials Chemistry and Physics, Vol. 270, 15 September 2021, 124760
Departamento
Universidad Pública de Navarra/Nafarroako Unibertsitate Publikoa. Institute for Advanced Materials and Mathematics - INAMAT2 /
Universidad Pública de Navarra. Departamento de Ciencias /
Nafarroako Unibertsitate Publikoa. Zientziak Saila /
Universidad Pública de Navarra. Departamento de Estadística, Informática y Matemáticas /
Nafarroako Unibertsitate Publikoa. Estatistika, Informatika eta Matematika Saila
Versión del editor
Entidades Financiadoras
P. Moriones is grateful to the 'Departamento de Industria y Tecnología, Comercio y Trabajo' of the Navarre Goverment (Spain) for the fellowships granted (Ref. number 175/01/08 and 269/01/08 , respectively). L. Cervera wishes to thank the Public University of Navarre for her Ph.D contract, as part of the scheme 'Contratos Pre-doctorales adscritos a Grupos e Institutos de Investigación de la Universidad Pública de Navarra'. This work has been carried out with the financial support of the Navarra Government (project number PC017-018 AMELEC).