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Effects of a fruit and vegetable-based nutraceutical on biomarkers of inflammation and oxidative status in the plasma of a healthy population: a placebo-controlled, double-blind, and randomized clinical trial
dc.creator | Arcusa, Raúl | es_ES |
dc.creator | Carrillo, Juan Ángel | es_ES |
dc.creator | Xandri-Martínez, Raquel | es_ES |
dc.creator | Cerdá, Begoña | es_ES |
dc.creator | Villaño Valencia, Débora | es_ES |
dc.creator | Marhuenda, Javier | es_ES |
dc.creator | Zafrilla, Pilar | es_ES |
dc.date.accessioned | 2024-03-20T15:36:16Z | |
dc.date.available | 2024-03-20T15:36:16Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Arcusa, R., Carrillo, J. Á., Xandri-Martínez, R., Cerdá, B., Villano, D., Marhuenda, J., Zafrilla, M. P. (2021) Effects of a fruit and vegetable-based nutraceutical on biomarkers of inflammation and oxidative status in the plasma of a healthy population: a placebo-controlled, double-blind, and randomized clinical trial. Molecules, 26(12), 1-14. https://doi.org/10.3390/molecules26123604. | en |
dc.identifier.issn | 1420-3049 | |
dc.identifier.uri | https://hdl.handle.net/2454/47744 | |
dc.description.abstract | There is scientific evidence of the positive effect of polyphenols from plant foods on inflammation and oxidative status. The aim of the present study was to investigate whether treatment with a high-polyphenolic nutraceutical reduces the plasmatic concentration of certain oxidative and inflammatory biomarkers in a healthy population. One hundred and eight subjects were selected and stratified by sex in the intervention group (n = 53) and the placebo group (n = 55). Ninety-two subjects completed the study after two 16-week treatment periods separated by a four-week washout period. The results revealed statistically significant differences in subjects treated with the polyphenolic extract compared to the placebo: A decrease in homocysteine, oxidized low-density lipoprotein (OxLDL), TNF-α, sTNFR1, and C-reactive protein (CRP). The most significant decrease was observed for OxLDL (from 78.98 ± 24.48 to 69.52 ± 15.64; p < 0.05) and CRP (from 1.50 ± 0.33 to 1.39 ± 0.37; p < 0.05), both showing significant differences compared to the placebo (p < 0.001). Moreover, catecholamines increased after the administration of the product under investigation, especially in the case of dopamine (from 15.43 ± 2.66 to 19.61 ± 5.73; p < 0.05). Therefore, the consumption of a nutraceutical based on fruit and vegetables with a high polyphenol content seems to improve the parameters related to health benefits (oxidative and inflammatory biomarkers), including remarkable changes in the expression of catecholamines. | en |
dc.description.sponsorship | This study was funded by the Juice Plus Company. | en |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | MDPI | en |
dc.relation.ispartof | Molecules 2021, 26(12), 3604 | en |
dc.rights | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Polyphenol | en |
dc.subject | Biomarkers | en |
dc.subject | Oxidative stress | en |
dc.subject | Fruit | en |
dc.subject | Vegetable | en |
dc.subject | Nutraceutical | en |
dc.title | Effects of a fruit and vegetable-based nutraceutical on biomarkers of inflammation and oxidative status in the plasma of a healthy population: a placebo-controlled, double-blind, and randomized clinical trial | en |
dc.type | Artículo / Artikulua | es |
dc.type | info:eu-repo/semantics/article | en |
dc.date.updated | 2024-03-20T15:18:57Z | |
dc.contributor.department | Agronomía, Biotecnología y Alimentación | es_ES |
dc.contributor.department | Agronomia, Bioteknologia eta Elikadura | eu |
dc.contributor.department | Institute on Innovation and Sustainable Development in Food Chain - ISFOOD | en |
dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.identifier.doi | 10.3390/molecules26123604 | |
dc.relation.publisherversion | https://doi.org/10.3390/molecules26123604 | |
dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |