Artículos de revista ISFOOD - ISFOOD aldizkari artikuluak
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Publication Open Access Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study(Public Library of Science, 2022) Martín Peláez, Sandra; Serra-Majem, Lluis; Cano Ibáñez, Noemí; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Corella, Dolores; Lassale, Camille; Martínez, Jose Alfredo; Alonso Gómez, Ángel M.; Wärnberg, Julia; Vioque, Jesús; Romaguera, Dora; López Miranda, José; Estruch, Ramón; Tinahones, Francisco J.; Lapetra, José; Fernández-Aranda, Fernando; Bueno Cavanillas, Aurora; Tur, Josep A.; Martín, Vicente; Pintó, Xavier; Delgado Rodríguez, Miguel; Matía-Martín, Pilar; Vidal, Josep; Vázquez, Clotilde; Daimiel, Lidia; Ros, Emilio; Toledo, Estefanía; Nishi, Stephanie K.; Sorli, Jose V.; Malcampo, Mireia; Zulet, María Ángeles; Moreno Rodríguez, Anaí; Cueto Galán, Raquel; Vivancos Aparicio, Diego; Colom, Antoni; García-Rios, Antonio; Casas, Rosa; Bernal López, M. Rosa; Santos Lozano, José Manuel; Vázquez, Zenaida; Gómez-Martínez, Carlos; Ortega Azorín, Carolina; Val, José Luis del; Abete, Itziar; Goikoetxea Bahon, Amaia; Pascual, Elena; Becerra-Tomás, Nerea; Chillarón, Juan J.; Sánchez Villegas, María Almudena; Institute on Innovation and Sustainable Development in Food Chain - ISFOODBackground Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ¿280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41 ±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). Conclusions Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response.