Bolado Concejo, Federico
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Bolado Concejo
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Federico
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Ciencias de la Salud
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Publication Open Access Cambios funcionales en el páncreas exocrino y en la morfología pancreática en pacientes con diabetes tipo 1(2018) Bolado Concejo, Federico; Zozaya Urmeneta, José Manuel; Ciencias de la Salud; Osasun ZientziakCon el presente estudio queremos analizar la prevalencia de cambios morfológicos, sugestivos de pancreatitis crónica, en el páncreas de diabéticos tipo 1. Se determinará además la prevalencia de insuficiencia pancreática exocrina. Posteriormente se correlacionarán ambos hallazgos: alteración morfológica y función exocrina. Se analizará su relación con factores de la diabetes como años de evolución, control glucémico y complicaciones crónicas. Se investigará por ello además el papel de la autoinmunidad en los cambios funcionales y morfológicos analizando la prevalencia de anticuerpos frente a antígenos del páncreas endocrino y el diagnóstico previo de otras enfermedades autoinmunes. Se analizarán también, por último, las posibles repercusiones clínicas y nutricionales de la alteración morfológica y funcional exocrina pancreática.Publication Open Access Low serum levels of prealbumin, retinol binding protein, and retinol are frequent in adult type 1 diabetic patients(Wiley, 2016) Forga, Lluís; Bolado Concejo, Federico; Goñi, María José; Tamayo Rodríguez, Ibai; Ibáñez Beroiz, Berta; Prieto, Carlos; Ciencias de la Salud; Osasun ZientziakAim. To determine the serum prealbumin (PA), retinol binding protein (RBP), and retinol levels in adult patients with type 1 diabetes (T1D) and to analyze some factors related to those levels. Methods. A total of 93 patients (47 women) were studied. Age, gender, BMI, duration of diabetes, chronic complications, HbA1c, lipid profile, creatinine, albumin, PA, RBP, and retinol were recorded. High and low parameter groups were compared by Mann-Whitney U and ¿2 tests. Correlation between parameters was analyzed by Spearman's test. Odds of low levels were analyzed by univariate logistic regression and included in the multivariate analysis when significant. Results. 49.5%, 48.4%, and 30.1% of patients displayed serum PA, RBP, and retinol levels below normal values, respectively. A high correlation (Rho > 0.8) between PA, RBP, and retinol serum levels was found. Patients presenting low levels of any of them were predominantly women, normal-weighted, and with lower levels of triglycerides and serum creatinine. No differences in age, macrovascular complications, duration of diabetes, or HbA1c values were observed when comparing low and normal parameter groups. Conclusion. Low serum levels of PA, RBP, and retinol are frequent in T1D adult patients. This alteration is influenced by female sex and serum creatinine and triglyceride levels.Publication Open Access Letter: Albumin_Does formulation matter? Authors' reply(Wiley, 2023) Leache, Leire; Gutiérrez Valencia, Marta; Saiz Fernández, Luis Carlos; Úriz, Juan; Bolado Concejo, Federico; García-Erce, José Antonio; Cantarelli, Lorenzo; Erviti López, Juan; Ciencias de la Salud; Osasun ZientziakIt is well known that retention of sodium and water is a key factor in the pathogenesis of ascites. Based on this, we believe that the reflection seems interesting and the hypothesis about the influence of the sodium content of albumin preparations on the results is theoretically feasible. However, we think that the impact would not be too relevant when compared to other mentioned contributing factors such as different study populations, diuretic management or albumin treatment patterns.Publication Open Access Aggressive or moderate fluid resuscitation in acute pancreatitis(Massachusetts Medical Society, 2022) Madaria, Enrique de; Buxbaum, James L.; Maisonneuve, Patrick; García García de Paredes, Ana; Zapater, Pedro; Guilabert, Lucía; Vaillo-Rocamora, Alicia; Rodríguez-Gandía, Miguel Á.; Donate-Ortega, Jesús; Lozada-Hernández, Edgard E.; Collazo Moreno, Alan J.R.; Lira-Aguilar, Alba; Llovet, Laura P.; Mehta, Rajiv; Tandel, Raj; Navarro, Pablo; Sánchez-Pardo, Ana M.; Sánchez-Marin, Claudia; Cobreros, Marina; Fernández-Cabrera, Idaira; Casals-Seoane, Fernando; Casas Deza, Diego; Lauret-Braña, Eugenia; Martí-Marqués, Eva; Camacho-Montaño, Laura M.; Ubieto, Verónica; Ganuza, Mikel; Bolado Concejo, Federico; ERICA Consortium; Ciencias de la Salud; Osasun ZientziakBACKGROUND: Early aggressive hydration is widely recommended for the management of acute pancreatitis, but evidence for this practice is limited. METHODS: At 18 centers, we randomly assigned patients who presented with acute pancreatitis to receive goal-directed aggressive or moderate resuscitation with lactated Ringer’s solution. Aggressive fluid resuscitation consisted of a bolus of 20 ml per kilogram of body weight, followed by 3 ml per kilogram per hour. Moderate fluid resuscitation consisted of a bolus of 10 ml per kilogram in patients with hypovolemia or no bolus in patients with normovolemia, followed by 1.5 ml per kilogram per hour in all patients in this group. Patients were assessed at 12, 24, 48, and 72 hours, and fluid resuscitation was adjusted according to the patient’s clinical status. The primary outcome was the development of moderately severe or severe pancreatitis during the hospitalization. The main safety outcome was fluid overload. The planned sample size was 744, with a first planned interim analysis after the enrollment of 248 patients. RESULTS: A total of 249 patients were included in the interim analysis. The trial was halted owing to between-group differences in the safety outcomes without a significant difference in the incidence of moderately severe or severe pancreatitis (22.1% in the aggressive-resuscitation group and 17.3% in the moderate-resuscitation group; adjusted relative risk, 1.30; 95% confidence interval [CI], 0.78 to 2.18; P=0.32). Fluid overload developed in 20.5% of the patients who received aggressive resuscitation and in 6.3% of those who received moderate resuscitation (adjusted relative risk, 2.85; 95% CI, 1.36 to 5.94, P=0.004). The median duration of hospitalization was 6 days (interquartile range, 4 to 8) in the aggressive-resuscitation group and 5 days (interquartile range, 3 to 7) in the moderate-resuscitation group. CONCLUSIONS: In this randomized trial involving patients with acute pancreatitis, early aggressive fluid resuscitation resulted in a higher incidence of fluid overload without improvement in clinical outcomes.