Vázquez Urio, Iria

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https://academica-e.unavarra.es/handle/2454/51348

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Vázquez Urio

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Iria

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Ciencias

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0000-0003-0027-6384

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751933

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812309

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Author: Odero, María D. × Subject: DNA Methylation ×

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    PublicationOpen Access
    Silencing of hsa-miR-124 by EVI1 in cell lines and patients with acute myeloid leukemia
    (National Academy of Sciences, 2010-01-07) Vázquez Urio, Iria; Maicas, Miren; Marcotegui, Nerea; Conchillo, Ana; Guruceaga, Elizabeth; Román-Gómez, José; Calasanz, María José; Agirre, Xabier; Prósper, Felipe; Odero, María D.; Ciencias; Zientziak
    We read with great interest the work published by Dickstein et al. (1) showing that induced EVI1 expression in a murine model silences miR-124 expression by DNA methylation. The EVI1 gene codes for a transcription factor implicated in the development and progression of high-risk acute myeloid leukemia (AML) (2, 3). We quantify the expression of 250 microRNAs (miRNAs; TaqManHuman miRNA assay set) in 15 myeloid cell lines. Statistical analysis comparing cell lines with and without EVI1 protein identified miRNAs differentially expressed (B > 0)