Silencing of hsa-miR-124 by EVI1 in cell lines and patients with acute myeloid leukemia
Date
2010-01-07
Authors
Maicas, Miren
Marcotegui, Nerea
Conchillo, Ana
Guruceaga, Elizabeth
Román-Gómez, José
Calasanz, María José
Agirre, Xabier
Prósper, Felipe
Odero, María D.
Director
Publisher
National Academy of Sciences
Acceso cerrado / Sarbide itxia
Artículo / Artikulua
Project identifier
- MICINN//PI081687/
Impacto
Abstract
We read with great interest the work published by Dickstein et al. (1) showing that induced EVI1 expression in a murine model silences miR-124 expression by DNA methylation. The EVI1 gene codes for a transcription factor implicated in the development and progression of high-risk acute myeloid leukemia (AML) (2, 3). We quantify the expression of 250 microRNAs (miRNAs; TaqManHuman miRNA assay set) in 15 myeloid cell lines. Statistical analysis comparing cell lines with and without EVI1 protein identified miRNAs differentially expressed (B > 0)
Description
Acceso cerrado a este documento. No se encuentra disponible para la consulta pública. Depositado en Academica-e para cumplir con los requisitos de evaluación y acreditación académica del autor/a (sexenios, acreditaciones, etc.).
Keywords
EVI1 Overexpression, hsa-miR-124 Silencing, DNA Methylation
Department
Ciencias / Zientziak
Faculty/School
Degree
Doctorate program
item.page.cita
Vázquez, I., Maicas, M., Marcotegui, N., Conchillo, A., Guruceaga, E., Roman-Gomez, J., Calasanz, M. J., Agirre, X., Prosper, F., Odero, M. D. (2010). Silencing of hsa-miR-124 by EVI1 in cell lines and patients with acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America, 107(44), 167-168. https://doi.org/10.1073/pnas.1011540107.
item.page.rights
© 2010 PNAS
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