Person:
Erausquin, Elena

Profile Picture

Email Address

person.page.identifierURI

https://academica-e.unavarra.es/handle/2454/51404

Birth Date

Research Projects

Organizational Units

Job Title

Last Name

Erausquin

First Name

Elena

person.page.departamento

Ciencias de la Salud

person.page.instituteName

ORCID

0000-0003-1560-9671

person.page.upna

TA136610

Name

Filters

20221
Reset filters

Settings

Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    PublicationOpen Access
    Identification of a broad lipid repertoire associated to the endothelial cell protein C receptor (EPCR)
    (Springer Nature, 2022) Erausquin, Elena; Morán-Garrido, María; Sáiz, Jorge; Barbas, Coral; Dichiara-Rodríguez, Gilda; Urdiciain Ezpeleta, Alejandro; López Sagaseta, Jacinto; Ciencias de la Salud; Osasun Zientziak; Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
    Evidence is mounting that the nature of the lipid bound to the endothelial cell protein C receptor (EPCR) has an impact on its biological roles, as observed in anticoagulation and more recently, in autoimmune disease. Phosphatidylethanolamine and phosphatidylcholine species dominate the EPCR lipid cargo, yet, the extent of diversity in the EPCR-associated lipid repertoire is still unknown and remains to be uncovered. We undertook mass spectrometry analyses to decipher the EPCR lipidome, and identified species not yet described as EPCR ligands, such as phosphatidylinositols and phosphatidylserines. Remarkably, we found further, more structurally divergent lipids classes, represented by ceramides and sphingomyelins, both in less abundant quantities. In support of our mass spectrometry results and previous studies, high-resolution crystal structures of EPCR in three different space groups point to a prevalent diacyl phospholipid moiety in EPCR¿s pocket but a mobile and ambiguous lipid polar head group. In sum, these studies indicate that EPCR can associate with varied lipid classes, which might impact its properties in anticoagulation and the onset of autoimmune disease.