Alcántara Alcántara, Juan Manuel
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Alcántara Alcántara
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Juan Manuel
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Ciencias de la Salud
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Publication Embargo Impact of 24-week supervised concurrent exercise on S-Klotho and vitamin D levels: a randomized controlled trial(Taylor & Francis, 2025-01-20) Amaro Gahete, Francisco J.; Espuch-Oliver, Andrea; Cano-Nieto, Amalia; Alcántara Alcántara, Juan Manuel; García-Lario, José Vicente; Haro Muñoz, Tomás de; Llamas Elvira, José M.; Muñoz Torres, Manuel; Castillo, Manuel J.; Labayen Goñi, Idoia; Ruiz, Jonatan R.; Ciencias de la Salud; Osasun Zientziak; Institute on Innovation and Sustainable Development in Food Chain - ISFOODThis study aimed to investigate the effects 24 weeks of supervised exercise training at different intensities on S-Klotho and 25-hydroxyvitamin D plasma levels in young adults. This report was based on a secondary analysis from the ACTIBATE single-center unblinded randomized controlled trial (ClinicalTrials.gov ID: NCT02365129). A total of 144 young adults (~34% men and ~66% women) aged between 18 and 25 years took part in the study. The participants were randomly assigned to 3 different groups: (i) concurrent exercise training program based on the international physical activity recommendations at vigorous intensity (Ex-Vigorous group), (ii) at moderate intensity (Ex-Moderate group), and (iii) control group (no exercise). S-Klotho and 25-hydroxyvitamin D plasma levels were determined before and after the 24-week intervention programme. A significant decrease of 25-hydroxyvitamin D plasma levels were identified across time in all groups (p < 0.001), whereas no significant differences across time were observed in S-Klotho plasma levels (p = 0.497). There was no time x group interaction neither in S-Klotho nor in 25-hydroxyvitamin D plasma levels (all p > 0.7). In summary, our results showed that 24 weeks of supervised concurrent exercise training does not induce significant changes on S-Klotho and 25-hydroxyvitamin D independently of the exercise intensity in young adults.Publication Open Access Intra-assessment resting metabolic rate variability is associated with cardiometabolic risk factors in middle-aged adults(MDPI, 2023) Alcántara Alcántara, Juan Manuel; Osuna Prieto, Francisco J.; Castillo, Manuel J.; Plaza Florido, Abel; Amaro Gahete, Francisco J.; Ciencias de la Salud; Osasun Zientziak; Institute on Innovation and Sustainable Development in Food Chain - ISFOODThe intra-assessment resting metabolic rate variability is related to cardiometabolic health, as suggested by previous literature. We studied whether that variability (expressed as coefficient of variation [CV; %]) for oxygen consumption (VO2), carbon dioxide production (VCO2), respiratory exchange ratio (RER), and resting energy expenditure (REE) is similar between men and women, and if is similarly associated with cardiometabolic risk factors. Gas exchange in 72 middle-aged adults was measured by indirect calorimetry. Anthropometrics and body composition, cardiorespiratory fitness, circulating cardiometabolic risk factors, and heart rhythm parameters were also determined. Men and women presented similar intra-assessment resting metabolic rate variability (all p > 0.05). Notably, in men, CV for RER was positively associated with BMI and adiposity (both standardized β = 0.35, Ps ≤ 0.048), while CVs for VO2, VCO2, and REE were negatively associated (standardized β ranged from −0.37 to −0.46, all p ≤ 0.036) with cardiometabolic risk factors. In women, CVs for VCO2 and REE were negatively associated with adiposity (both standardized β = −0.36, Ps ≤ 0.041) and cardiometabolic risk Z-score (standardized β = −0.40 and −0.38, respectively, Ps ≤ 0.05). In conclusion, intra-assessment resting metabolic rate variability could be considered an indicator of cardiometabolic health in middle-aged adults.