Open Access
Impact of methods for data selection on the day-to-day reproducibility of resting metabolic rate assessed with four different metabolic carts
(Elsevier, 2023) Alcántara Alcántara, Juan Manuel; Jurado Fasoli, Lucas; Dote-Montero, Manuel; Merchán Ramírez, Elisa; Amaro Gahete, Francisco J.; Labayen Goñi, Idoia; Ruiz, Jonatan R.; Sánchez Delgado, Guillermo; Ciencias de la Salud; Osasun Zientziak; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD
Background and aims: Accomplishing a high day-to-day reproducibility is important to detect changes in resting metabolic rate (RMR) and respiratory exchange ratio (RER) that may be produced after an intervention or for monitoring patients’ metabolism over time. We aimed to analyze: (i) the influence of different methods for selecting indirect calorimetry data on RMR and RER assessments; and, (ii) whether these methods influence RMR and RER day-to-day reproducibility. Methods and results: Twenty-eight young adults accomplished 4 consecutive RMR assessments (30-min each), using the Q-NRG (Cosmed, Rome, Italy), the Vyntus CPX (Jaeger-CareFusion, Höchberg, Germany), the Omnical (Maastricht Instruments, Maastricht, The Netherlands), and the Ultima CardiO2 (Medgraphics Corporation, St. Paul, Minnesota, USA) carts, on 2 consecutive mornings. Three types of methods were used: (i) short (periods of 5 consecutive minutes; 6e10, 11e15, 16e20, 21e25, and 26e30 min) and long time intervals (TI) methods (6e25 and 6 e30 min); (ii) steady state (SSt methods); and, (iii) methods filtering the data by thresholding from the mean RMR (filtering methods). RMR and RER were similar when using different methods (except RMR for the Vyntus and RER for the Q-NRG). Conversely, using different methods impacted RMR (all P 0.037) and/or RER (P 0.009) day-to-day reproducibility in all carts. The 6e25 min and the 6e30 min long TI methods yielded more reproducible measurements for all metabolic carts. Conclusion: The 6e25 min and 6e30 min should be the preferred methods for selecting data, as they result in the highest day-to-day reproducibility of RMR and RER assessments.
Open Access
Impact of lifestyle moderate-to-vigorous physical activity timing on glycemic control in sedentary adults with overweight/obesity and metabolic impairments
(Wiley, 2024-06-10) Clavero-Jimeno, Antonio; Dote-Montero, Manuel; Migueles, Jairo H.; Camacho-Cardenosa, Alba; Osés Recalde, Maddi; Echarte Medina, Jon; Alcántara Alcántara, Juan Manuel; Muñoz Torres, Manuel; Labayen Goñi, Idoia; Ruiz, Jonatan R.; Ciencias de la Salud; Osasun Zientziak; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD; Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
Objective: Moderate-to-vigorous physical activity (MVPA) improves glucose levels; however, whether its timing affects daily glycemic control remains unclear. This study aims to investigate the impact of lifestyle MVPA timing on daily glycemic control in sedentary adults with overweight/obesity and metabolic impairments. Methods: A total of 186 adults (50% women; age, 46.8 [SD 6.2] years) with overweight/obesity (BMI, 32.9 [SD 3.5] kg/m2) and at least one metabolic impairment participated in this cross-sectional study. MVPA and glucose patterns were simultaneously monitored over a 14-day period using a triaxial accelerometer worn on the nondominant wrist and a continuous glucose-monitoring device, respectively. Each day was classified as “inactive” if no MVPA was accumulated; as “morning,” “afternoon,” or “evening” if >50% of the MVPA minutes for that day were accumulated between 0600 and 1200, 1200 and 1800, or 1800 and 0000 hours, respectively; or as “mixed” if none of the defined time windows accounted for >50% of the MVPA for that day. Results: Accumulating >50% of total MVPA during the evening was associated with lower 24-h (mean difference [95% CI], −1.26 mg/dL [95% CI: −2.2 to −0.4]), diurnal (−1.10 mg/dL [95% CI: −2.0 to −0.2]), and nocturnal mean glucose levels (−2.16 mg/dL [95% CI: −3.5 to −0.8]) compared with being inactive. This association was stronger in those participants with impaired glucose regulation. The pattern of these associations was similar in both men and women. Conclusions: These findings suggest that timing of lifestyle MVPA is significant. Specifically, accumulating more MVPA during the evening appears to have a beneficial effect on glucose homeostasis in sedentary adults with overweight/obesity and metabolic impairments.
Open Access
Effects of early, late and self-selected time-restricted eating on visceral adipose tissue and cardiometabolic health in participants with overweight or obesity: a randomized controlled trial
(Nature Research, 2025-01-07) Dote-Montero, Manuel; Clavero-Jimeno, Antonio; Merchán Ramírez, Elisa; Osés Recalde, Maddi; Echarte Medina, Jon; Camacho-Cardenosa, Alba; Concepción Álvarez, Mara de la Caridad; Amaro Gahete, Francisco J.; Alcántara Alcántara, Juan Manuel; López-Vázquez, Alejandro; Cupeiro, Rocío; Migueles, Jairo H.; De la O, Alejandro; García Pérez, Patricia Virginia; Contreras-Bolivar, Victoria ; Muñoz-Garach, Araceli; Zugasti Murillo, Ana; Petrina Jáuregui, María Estrella; Álvarez de Eulate, Natalia; Goñi Gironés, María Elena; Armendáriz Brugos, Cristina; González Cejudo, María Trinidad; Martín-Rodríguez, José L.; Idoate, Fernando; Cabeza Laguna, Rafael; Carneiro-Barrera, Almudena; Cabo, Rafael de; Muñoz Torres, Manuel; Labayen Goñi, Idoia; Ruiz, Jonatan R.; Ciencias de la Salud; Osasun Zientziak; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD; Ingeniería Eléctrica, Electrónica y de Comunicación; Ingeniaritza Elektrikoa, Elektronikoa eta Telekomunikazio Ingeniaritza; Agronomía, Biotecnología y Alimentación; Agronomia, Bioteknologia eta Elikadura; Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa; Gobierno de Navarra / Nafarroako Gobernua
The optimal eating window for time-restricted eating (TRE) remains unclear, particularly its impact on visceral adipose tissue (VAT), which is associated with cardiometabolic morbidity and mortality. We investigated the effects of three TRE schedules (8 h windows in the early day, late day and participant-chosen times) combined with usual care (UC, based on education about the Mediterranean diet) versus UC alone over 12 weeks in adults with overweight or obesity. The primary outcome was VAT changes measured by magnetic resonance imaging. A total of 197 participants were randomized to UC (n = 49), early TRE (n = 49), late TRE (n = 52) or self-selected TRE (n = 47). No significant differences were found in VAT changes between early TRE (mean difference (MD): −4%; 95% confidence interval (CI), −12 to 4; P = 0.87), late TRE (MD: −6%; 95% CI, −13 to 2; P = 0.31) and self-selected TRE (MD: −3%; 95% CI, −11 to 5; P ≥ 0.99) compared with UC, nor among the TRE groups (all P ≥ 0.99). No serious adverse events occurred; five participants reported mild adverse events. Adherence was high (85–88%) across TRE groups. These findings suggest that adding TRE, irrespective of eating window timing, offers no additional benefit over a Mediterranean diet alone in reducing VAT. TRE appears to be a safe, well-tolerated and feasible dietary approach for adults with overweight or obesity. ClinicalTrials.gov registration: NCT05310721.

Alcántara Alcántara, Juan Manuel

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