Person: Socorro Leránoz, Abián Bentor
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Socorro Leránoz
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Abián Bentor
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Ingeniería Eléctrica, Electrónica y de Comunicación
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ISC. Institute of Smart Cities
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0000-0003-4843-9023
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9858
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Publication Open Access Monitoring the etching process in LPFGs towards development of highly sensitive sensors(MDPI, 2017) Del Villar, Ignacio; Cruz, José Luis; Socorro Leránoz, Abián Bentor; Díaz Lucas, Silvia; Corres Sanz, Jesús María; Arregui San Martín, Francisco Javier; Matías Maestro, Ignacio; Ingeniaritza Elektrikoa eta Elektronikoa; Institute for Advanced Materials and Mathematics - INAMAT2; Ingeniería Eléctrica y Electrónica; Gobierno de Navarra / Nafarroako Gobernua: 2016/PI008; Gobierno de Navarra / Nafarroako Gobernua: 2016/PC025; Gobierno de Navarra / Nafarroako Gobernua: 2016/PC026In this work, the monitoring of the etching process up to a diameter of 30 µm of two LPFG structures has been compared, one of them had initially 125 µm, whereas the second one had 80 µm. By tracking the wavelength shift of the resonance bands during the etching process it is possible to check the quality of etching process (the 80 µm fibre performs better than de 125 µm fibre), and to stop for a specific cladding mode coupling, which permits to obtain an improved sensitivity compared to the initial structure.Publication Open Access Ultrahigh sensitive detection of tau protein as Alzheimer's biomarker via microfluidics and nanofunctionalized optical fiber sensors(Wiley, 2022) Chiavaioli, Francesco; Santano Rivero, Desiree; Del Villar, Ignacio; Socorro Leránoz, Abián Bentor; Zhang, Xuejun; Li, Kaiwei; Santamaría Martínez, Enrique; Fernández Irigoyen, Joaquín; Baldini, Francesco; Van den Hove, Daniel L. A.; Shi, Lei; Bi, Wei; Guo, Tuan; Giannetti, Ambra; Matías Maestro, Ignacio; Institute of Smart Cities - ISC; Ingeniería Eléctrica y Electrónica; Ingeniaritza Elektrikoa eta Elektronikoa; Universidad Pública de Navarra / Nafarroako Unibertsitate PublikoaAlzheimer’s disease (AD) is one of the most common neurodegenerative illnesses displaying the highest death rate in the elderly. However, the existing AD diagnostic system remains elusive due to lack of a technology that may ensure enough sensitivity and reproducibility, detection accuracy, and specificity. Herein, a straightforward approach is reported to realize lab-on-fiber (LoF) technology for AD biomarker detection based on a D-shaped single-mode fiber combined with nanometer-scale metal-oxide film. The proposed sensing system, which permits the generation of lossy-mode resonance (LMR), remarkably increases the evanescent field of light guided through the fiber, and hence the fiber-surrounding medium interaction. Moreover, such optical sensors are highly repeatable in results and can safely be embedded into a compact and stable microfluidic system. Herein, the specific detection of Tau protein (as one of the classical AD biomarkers that is highly correlated with AD progression) in a complex biofluid with a detection limit of 10 12 M and over a wide concentration range (10 3 –10 μg mL 1 ) is successfully demonstrated. The proposed LoF biosensor is an appealing solution for rapid, sub-microliter dose and highly sensitive detection of analytes at low concentrations, hereby having the potential toward early screening and personalized medicine in AD.Publication Open Access Mode transition in complex refractive index coated single-mode–multimode–single-mode structure(Optical Society of America, 2013) Socorro Leránoz, Abián Bentor; Del Villar, Ignacio; Corres Sanz, Jesús María; Arregui San Martín, Francisco Javier; Matías Maestro, Ignacio; Ingeniería Eléctrica y Electrónica; Ingeniaritza Elektrikoa eta Elektronikoa; Gobierno de Navarra / Nafarroako GobernuaBy coating a single-mode–multimode–single-mode (SMS) structure with a high refractive index thin-film it is possible to obtain a transition of modes for specific combinations of thin-film thickness, thinfilm refractive index and surrounding medium refractive index, which permits to develop devices with a high sensitivity to specific parameters. In order to gain a better knowledge of the phenomenon the experimental results are corroborated numerically with the Transfer-Matrix-Method. The influence of losses in the thin-film has also been studied. The results obtained prove that a thin-film coated SMS structure is a simple and costeffective platform for development of sensors and optical filters.Publication Open Access Optical system based on multiplexed FBGs to monitor hand movements(IEEE, 2021) Socorro Leránoz, Abián Bentor; Díaz Lucas, Silvia; Castillo, Silvia; Dreyer, Uilian José; Martelli, Cicero; Cardozo da Silva, Jean Carlos; Uzqueda Esteban, Itziar; Gómez Fernández, Marisol; Ruiz Zamarreño, Carlos; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren; Estatistika, Informatika eta Matematika; Institute of Smart Cities - ISC; Institute for Advanced Materials and Mathematics - INAMAT2; Ingeniería Eléctrica, Electrónica y de Comunicación; Estadística, Informática y Matemáticas; Gobierno de Navarra / Nafarroako GobernuaThis contribution reports the development and characterization of an optical system based on parallel Fiber Bragg Gratings (FBGs) to monitor the movements of the wrist and fingers of a hand. The system consisted of a reflective configuration made of FBGs detecting the movements of the fingers and one more located on the wrist as a reference. All FBGs were multiplexed in order to collect the basic movements of the hand. Fibers were embedded in polydimethylsiloxane for protection and to give flexibility to the optical detection setup. Measurements of strain, angle and torsion were performed during the experiments, obtaining sensitivities up to 1.29 pm/ \mu \varepsilon in strain and 64.23 pm/° in angle. Also, a study on the influence of a single sensor on the performance of the whole system was analyzed for a complete study of this proof of concept. The obtained results present a simple system that can be used to monitor the positions of the hand or for the rehabilitation of patients suffering from neuromotor or post-stroke diseases.Publication Open Access Multimode – coreless – multimode fiber-based sensors: theoretical and experimental study(IEEE, 2019) San Fabián García, Noé; Socorro Leránoz, Abián Bentor; Del Villar, Ignacio; Díaz Lucas, Silvia; Matías Maestro, Ignacio; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren; Institute of Smart Cities - ISC; Ingeniería Eléctrica, Electrónica y de ComunicaciónThis paper presents a complete study on the spectral behavior of a multimode-coreless-multimode fiber-optic structure, as well as its application as a refractometer and a liquid level sensor. The combination of two standard multimode fibers fused to a coreless fiber segment allows generating narrow interferometric bands in the optical spectrum, whose sensitivity can be improved by an adequate selection of the dimensions of the device (the coreless segment length and the diameter of the sensing area). A second way to improve the performance of the device is to deposit a thin film of SnO2, which allows increasing the sensitivity up to 314 nm/RIU. This widens the number of applications where this structure can be used. As an example, a liquid level sensor with 0.73 nm/mm sensitivity is presented.Publication Open Access Fiber-optic biosensor based on lossy mode resonances(Elsevier, 2012) Socorro Leránoz, Abián Bentor; Corres Sanz, Jesús María; Del Villar, Ignacio; Arregui San Martín, Francisco Javier; Matías Maestro, Ignacio; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren; Institute of Smart Cities - ISC; Ingeniería Eléctrica, Electrónica y de ComunicaciónPublication Open Access Fiber-optic immunosensor based on lossy mode resonances induced by indium tin oxide thin-films(IEEE, 2017) Socorro Leránoz, Abián Bentor; Del Villar, Ignacio; Corres Sanz, Jesús María; Arregui San Martín, Francisco Javier; Matías Maestro, Ignacio; Ingeniería Eléctrica y Electrónica; Ingeniaritza Elektrikoa eta Elektronikoa; Institute of Smart Cities - ISCA novel immunosensor based on lossy mode resonances (LMRs) induced in optical fibers is developed in this contribution. Indium tin oxide (ITO) is sputtered on the optical substrate to generate an LMR in the transmission spectrum. Type G immunoglobulins (IgGs) are then attached to the ITO-coated fiber using (3-glycidyloxypropyl)trimethoxysilane (GPTMS). A phosphate buffer saline solution containing anti-IgGs is used to detect the biological reactions. The presented device is capable of detecting anti-IgG concentrations up to 10 nM. These results will permit the fabrication of biosensors based on a covalent attachment of bioreceptors over an LMR inducing thin-film.Publication Open Access Label-free wavelength and phase detection based SMS fiber immunosensors optimized with cladding etching(Elsevier, 2018) Cardona-Maya, Yamile; Socorro Leránoz, Abián Bentor; Del Villar, Ignacio; Cruz, José Luis; Corres Sanz, Jesús María; Botero-Cadavid, Juan F.; Ingeniería Eléctrica y Electrónica; Ingeniaritza Elektrikoa eta Elektronikoa; Gobierno de Navarra / Nafarroako Gobernua 2016/PI044; Gobierno de Navarra / Nafarroako Gobernua 2016/PC025; Gobierno de Navarra / Nafarroako Gobernua 2016/PC026The performance of E-SMS (Etched Singlemode-Multimode-Singlemode) optical fiber structures as immunosensors has been assessed by the implementation of antibody/antigen immunoassays. Through this procedure it has been proven that E-SMS structures are effective and suitable optical platforms for label-free biosensing. Using the phase shift and tracking the wavelength response it was found that the fabricated E-SMS devices exhibited limits of detection (LOD) down up to concentrations of 0.2mg/L of antigens in solution. This was achieved by coating the E-SMS with an antibody-based biolayer (goat IgG) that is able to determine the presence of anti-goat IgG antigen. Both a wavelength detection and a fast Fourier transform (FFT) analysis technique were used to perform this analysis. The FFT method showed similar results to those observed with the most traditional wavelength analysis, but with the advantage of a simpler detection system that makes unnecessary the use of sophisticated optical interrogators.Publication Open Access Temperature sensor based on a hybrid ITOsilica resonant cavity(Optical Society of America, 2015) Socorro Leránoz, Abián Bentor; Soltani, Soheil; Del Villar, Ignacio; Corres Sanz, Jesús María; Armani, Andrea M.; Ingeniería Eléctrica y Electrónica; Ingeniaritza Elektrikoa eta Elektronikoa; Universidad Pública de Navarra / Nafarroako Unibertsitate PublikoaIntegrated optical devices comprised of multiple material systems are able to achieve unique performance characteristics, enabling applications in sensing and in telecommunications. Due to ease of fabrication, the majority of previous work has focused on polymer-dielectric or polymer-semiconductor systems. However, the environmental stability of polymers is limited. In the present work, a hybrid device comprised of an indium tin oxide (ITO) coating on a silicon dioxide toroidal resonant cavity is fabricated. Finite element method simulations of the optical field in the multi-material device are performed, and the optical mode profile is significantly altered by the high index film. The quality factor is also measured and is material loss limited. Additionally, its performance as a temperature sensor is characterized. Due to the high thermo-optic coefficient of ITO and the localization of the optical field in the ITO layer, the hybrid temperature sensor demonstrates a nearly 3-fold improvement in performance over the conventional silica device.Publication Open Access Lossy mode resonance based microfluidic platform developed on planar waveguide for biosensing applications(MDPI, 2022) Benítez Pérez, Melanys; Zubiate Orzanco, Pablo; Del Villar, Ignacio; Socorro Leránoz, Abián Bentor; Matías Maestro, Ignacio; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren; Institute of Smart Cities - ISC; Ingeniería Eléctrica, Electrónica y de Comunicación; Universidad Pública de Navarra / Nafarroako Unibertsitate PublikoaThe development of resonance phenomena-based optical biosensors has gained relevance in recent years due to the excellent optical fiber properties and progress in the research on materials and techniques that allow resonance generation. However, for lossy mode resonance (LMR)-based sensors, the optical fiber presents disadvantages, such as the need for splicing the sensor head and the complex polarization control. To avoid these issues, planar waveguides such as coverslips are easier to handle, cost-effective, and more robust structures. In this work, a microfluidic LMR-based planar waveguide platform was proposed, and its use for biosensing applications was evaluated by detecting anti-immunoglobulin G (anti-IgG). In order to generate the wavelength resonance, the sensor surface was coated with a titanium dioxide (TiO2) thin-film. IgG antibodies were immobilized by covalent binding, and the detection assay was carried out by injecting anti-IgG in PBS buffer solutions from 5 to 20 μg/mL. The LMR wavelength shifted to higher values when increasing the analyte concentration, which means that the proposed system was able to detect the IgG/anti-IgG binding. The calibration curve was built from the experimental data obtained in three repetitions of the assay. In this way, a prototype of an LMR-based biosensing microfluidic platform developed on planar substrates was obtained for the first time