Arregui San Martín, Francisco Javier
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Arregui San Martín
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Francisco Javier
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Ingeniería Eléctrica, Electrónica y de Comunicación
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ISC. Institute of Smart Cities
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Publication Open Access Fiber-based label-free D-dimer detection for early diagnosis of venous thromboembolism(SPIE, 2020) Zubiate Orzanco, Pablo; Urrutia Azcona, Aitor; Ruiz Zamarreño, Carlos; Fernández Irigoyen, Joaquín; Giannetti, Ambra; Baldini, Francesco; Díaz Lucas, Silvia; Matías Maestro, Ignacio; Arregui San Martín, Francisco Javier; Santamaría Martínez, Enrique; Del Villar, Ignacio; Chiavaioli, Francesco; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren; Institute of Smart Cities - ISC; Ingeniería Eléctrica, Electrónica y de ComunicaciónD-dimer is a useful diagnostic biomarker for deep vein thrombosis or pulmonary embolism, collectively referred to as venous thromboembolism (VTE). The ability to detect in real-time the amount of D-dimer with a fast and reliable method is a key step to anticipate the appearance of these diseases. The combination of fiber-optic-based platforms for biosensing with the nanotechnologies is opening up the chance for the development of in situ, portable, lightweight, versatile, reliable and high-performance optical sensing devices towards lab-on-fiber technology. The generation of lossy mode resonances (LMRs) by means of the deposition of nm-thick absorbing metal-oxide films on special geometric-modified fibers allows measuring precisely and accurately surface refractive index changes, which are due to the binding interaction between a biological recognition element and the analyte under investigation. This approach enhances the light-matter interaction in a strong way, thus turning out to be more sensitive compared to other optical technology platforms, such as fiber gratings or surface plasmon resonance. Here, the results of a highly specific and sensitive biosensor for the detection of D-dimer based on LMR in fiber-optics are presented by monitoring in real-time the shift of the LMR related to the biomolecule interactions thanks to a conventional wavelength-interrogation system and an ad-hoc developed microfluidics. A detection limit of 100 ng/mL, a value 5-fold below the clinical cutoff value, has been attained for D-dimer spiked in human serum. The comparison of the results achieved with proteomics-based methodologies, which allows for the identification of betaand gamma-chains of fibrinogen, demonstrates the ability of our platform to specifically (>90%) recognize D-dimer.Publication Open Access Simultaneous measurement of humidity and temperature based on a partially coated optical fiber long period grating(Elsevier, 2016) Urrutia Azcona, Aitor; Goicoechea Fernández, Javier; Ricchiuti, Amelia L.; Barrera, D.; Arregui San Martín, Francisco Javier; Ingeniaritza Elektrikoa eta Elektronikoa; Institute of Smart Cities - ISC; Ingeniería Eléctrica y ElectrónicaA humidity and temperature optical fiber sensor based on a long-period grating (LPG), which can provide simultaneous response to both magnitudes, is proposed and demonstrated via experiments. Previously, the LPG was fully coated with humidity sensitive nanostructured polymeric thin films by the Layer-by-Layer (LbL) nano assembly technique. Hence the surrounding refractive index was changed, so provoking wavelength shifts of the attenuation bands of the transmission spectrum. This fully coated LPG was exposed to relative humidity (RH) and temperature tests, varying from 20% to 80% RH and from 25 to 85 °C, respectively. Then, half of the LPG coating was chemically removed and this results in the splitting of the main attenuation band into two different contributions. When this semi-coated LPG was also exposed to RH and temperature tests, the new two attenuation bands presented different behaviors for humidity and temperature. This novel dual-wavelength based sensing method enables the simultaneous measurement of RH and temperature using only one LPG.Publication Open Access Experimental demonstration of lossy mode resonance generation for transverse-magnetic and transverse-electric polarizations(Optica Publishing Group, 2013) Ruiz Zamarreño, Carlos; Zubiate Orzanco, Pablo; Sagüés García, Mikel; Matías Maestro, Ignacio; Arregui San Martín, Francisco Javier; Ingeniería Eléctrica y Electrónica; Ingeniaritza Elektrikoa eta ElektronikoaThis Letter, presents the fabrication of lossy mode resonance (LMR) devices based on titanium dioxide (TiO2)/ poly(sodium 4-styrenesulfonate) (PSS) coatings deposited on side-polished D-shaped optical fibers. TiO2 thin films have been obtained by means of the layer-by-layer (LbL) self-assembly technique. LbL enables us to produce smooth and homogeneous coatings on the polished side of the fiber. This permits us to couple light from the waveguide to the TiO2-coating/external medium region at specific wavelength ranges. The generation of LMRs depends on the coating thickness, so that thicker coatings can produce more resonances. LMRs are sensitive to the external medium refractive index, which allows its utilization as refractometers. The characteristic D-shaped architecture of the devices employed in this Letter enables us to distinguish TE and TM polarizations, which had not been possible before with regular optical fibers due to their cylindrical symmetry. The results presented here show for the first time the experimental demonstration of the generation of LMRs produced by both TM and TE polarizations. More specifically, for these TiO2/PSS thin films, the TM and TM modes of the LMRs show a wavelength shift of 226 nm for the first-order LMR and 56 nm for the second-order LMR.Publication Open Access Microstructured optical fiber sensor for soil moisture measurements(Optical Society of America, 2018) López Aldaba, Aitor; López Torres, Diego; Campo-Bescós, Miguel; López Rodríguez, José Javier; Yerro Lizarazu, David; Elosúa Aguado, César; Arregui San Martín, Francisco Javier; Auguste, Jean-Louis; Jamier, Raphael; Roy, Philippe; López-Amo Sáinz, Manuel; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren; Ingeniaritza; Institute of Smart Cities - ISC; Ingeniería Eléctrica, Electrónica y de Comunicación; IngenieríaA discrete sensor based on a Sn0₂-FP (Fabry-Pérot) cavity is presented and characterized in real soil conditions. Results are compared, for the first time to our knowledge, with a commercial capacitive sensor and gravimetric measurements.Publication Open Access Study and optimization of self-assembled polymeric multilayer structures with neutral red for pH sensing applications(Hindawi / Wiley, 2008) Goicoechea Fernández, Javier; Arregui San Martín, Francisco Javier; Corres Sanz, Jesús María; Matías Maestro, Ignacio; Ingeniería Eléctrica y Electrónica; Ingeniaritza Elektrikoa eta ElektronikoaThe characterization of nanostructured thin films is critical in the design and fabrication of optical sensors. Particularly, this work is a detailed study of the properties of layer-by-layer electrostatic self-assembled multilayer (LbL) structures fabricated using poly(allylamine hydrochloride) (PAH) and Neutral Red (NR) as cations, and poly(acrylic acid) (PAA) as polyanion. These LbL films, due to the colorimetric properties of the NR, are suitable for sensor applications such as pH sensing in the physiological range. In the (PAH+NR/PAA) LbL structure, it has been observed a very important influence of the pH of the solutions in the properties of the resultant films. Different techniques such as spectroscopy and atomic force microscopy (AFM) are combined to characterize the films, and the results are analyzed showing coherence with previous works. The LbL structure is finally optimized and dramatically improved nanostructured films were fabricated, showing good sensing properties, short response times, and good stability.Publication Open Access In situ synthesis of gold nanoparticles in layer-b y-layer polymeric coatings for the fabrication of optical fiber sensors(MDPI, 2022) Martínez Hernández, María Elena; Goicoechea Fernández, Javier; Rivero Fuente, Pedro J.; Arregui San Martín, Francisco Javier; Ingeniaritza; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren; Institute of Smart Cities - ISC; Institute for Advanced Materials and Mathematics - INAMAT2; Ingeniería; Ingeniería Eléctrica, Electrónica y de ComunicaciónA new method is proposed to tune the interferometric response of wavelength-based optical fiber sensors. Using the nanoparticle in situ synthesis (ISS) technique, it is possible to synthesize gold nanoparticles (AuNPs) within a pre-existing polymeric thin film deposited at the end-face of an optical fiber. This post-process technique allows us to adjust the optical response of the device. The effect of the progressive synthesis of AuNPs upon polymeric film contributed to a remarkable optical contrast enhancement and a very high tuning capability of the reflection spectra in the visible and near-infrared region. The spectral response of the sensor to relative humidity (RH) variations was studied as a proof of concept. These results suggest that the ISS technique can be a useful tool for fiber optic sensor manufacturing.Publication Open Access A comprehensive review: materials for the fabrication of optical fiber refractometers based on lossy mode resonance(MDPI, 2020) Ozcariz Celaya, Aritz; Ruiz Zamarreño, Carlos; Arregui San Martín, Francisco Javier; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren; Institute of Smart Cities - ISC; Ingeniería Eléctrica, Electrónica y de Comunicación; Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa, PJUPNA26Lossy mode resonance based sensors have been extensively studied in recent years. The versatility of the lossy mode resonance phenomenon has led to the development of sensors based on different configurations that make use of a wide range of materials. The coating material is one of the key elements in the performance of a refractometer. This review paper intends to provide a global view of the wide range of coating materials available for the development of lossy mode resonance based refractometers.Publication Open Access Design rules for lossy mode resonance based sensors(Optical Society of America, 2012) Del Villar, Ignacio; Hernáez Sáenz de Zaitigui, Miguel; Ruiz Zamarreño, Carlos; Sánchez Zábal, Pedro; Fernández Valdivielso, Carlos; Arregui San Martín, Francisco Javier; Matías Maestro, Ignacio; Ingeniería Eléctrica y Electrónica; Ingeniaritza Elektrikoa eta Elektronikoa; Gobierno de Navarra / Nafarroako GobernuaLossy mode resonances can be obtained in the transmission spectrum of cladding removed multimode optical fiber coated with a thin-film. The sensitivity of these devices to changes in the properties of the coating or the surrounding medium can be optimized by means of the adequate parameterization of the coating refractive index, the coating thickness and the surrounding medium refractive index (SMRI). Some basic rules of design, which enable the selection of the best parameters for each specific sensing application, are indicated in this work.Publication Open Access Fiber optic sensor based on fluorescence quenching for heavy metal detection(IEEE, 2020) Fuentes-Rubio, Yadira A.; Domínguez Cruz, René; Baldovino Pantaleón, Oscar; Ruiz Zamarreño, Carlos; Arregui San Martín, Francisco Javier; Ingeniería Eléctrica, Electrónica y de Comunicación; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio IngeniaritzarenIn this paper, we present the preliminary results of a fiber optic sensor based on fluorescence quenching induced by mercury (Hg) concentrations presence in aqueous solutions. The fabrication of the sensor head consists of a methyl red coating over multimode fiber tip using thermoplastic polyurethane to immobilize the thin layer. The sensor device was tested in a Hg molar concentration ranges 10-10,000 nmol/L. The experimental results show a linear dependence of the induced fluorescence quenching related to the Hg molar concentration.Publication Open Access Luminescence-based optical sensors fabricated by means of the layer-by-layer nano-assembly technique(MDPI, 2017) Acha Morrás, Nerea de; Elosúa Aguado, César; Matías Maestro, Ignacio; Arregui San Martín, Francisco Javier; Ingeniaritza Elektrikoa eta Elektronikoa; Institute of Smart Cities - ISC; Ingeniería Eléctrica y ElectrónicaLuminescence-based sensing applications range from agriculture to biology, including medicine and environmental care, which indicates the importance of this technique as a detection tool. Luminescent optical sensors are required to be highly stable, sensitive, and selective, three crucial features that can be achieved by fabricating them by means of the layer-by-layer nano-assembly technique. This method permits us to tailor the sensors0 properties at the nanometer scale, avoiding luminophore aggregation and, hence, self-quenching, promoting the diffusion of the target analytes, and building a barrier against the undesired molecules. These characteristics give rise to the fabrication of custom-made sensors for each particular application.