(Nature, 2025-07-03) Soto Ruiz, María Nelia; Escalada Hernández, Paula; Pimentel Parra, Gustavo Adolfo; García Vivar, Cristina; Ciencias de la Salud; Osasun Zientziak
This study aimed to assess the quality of life (QOL) of long-term breast cancer survivors (LT-BCS), disease-free 5 years after completing primary treatments, and to identify sociodemographic and clinical factors associated with their QOL. A descriptive cross-sectional study was conducted with LT-BCS from the Navarra region in Spain. The QOL was assessed using the Spanish version of the QOL scale for cancer survivors. Sociodemographic and clinical data, time since treatment completion, and lifestyle factors were also collected. Bivariate statistical analysis and multiple regression were used to explore associations between independent variables and QOL and its domains. A total of 188 LT-BCS participated, with a mean age of 57.55 years and a mean survival time of 10.22 years. The overall QOL score was 5.77/10, with physical well-being scoring the highest and spiritual wellbeing the lowest. Age, occupation, and moderate physical activity were associated with better QOL, while total mastectomy, early menopause, and recurrences had a negative impact. Radiotherapy was associated with improved overall QOL. Regression models confirmed these associations, except for spiritual well-being. The study identifies key factors affecting the QOL of LT-BCS, a population that has been relatively underrepresented in scientific literature. It provides valuable insights into their distinct physical and psychological sequelae, contributing to a more comprehensive understanding of their long-term well-being. Sequelae of breast cancer persist, affecting long-term survivors’ wellbeing. Despite the growing importance of supportive care, many women lack proper follow-up. This study underscores the need for strategies such as survivorship care plans to improve coordination and support, addressing both psychological impacts and physical well-being.
