Open Access
Nitrogen doped carbon dots as a photocatalyst based on biomass: a life cycle assessment
(Elsevier, 2023) Rodríguez-Carballo, Gabriela; Moreno-Tost, Ramón; Fernandes, Sónia; Esteves da Silva, Joaquim C.G.; Pinto da Silva, Luís; Castro Galiano, Eulogio; Algarra González, Manuel; Ciencias; Zientziak; Institute for Advanced Materials and Mathematics - INAMAT2
The effectiveness of various transition metal phosphate-based acid catalysts, including vanadium and niobium, in the hydrothermal synthesis of carbon dots (CDs), has been assessed. Two sources of carbohydrates were employed for this: commercial xylose and liquor of xylose produced by processing olive pits. Catalysts were identified using the NH3-TPD, DTA/TG, XRD, and XPS techniques. The reaction was conducted for 4 h at a temperature of 180 °C. The existence of such nanoparticles, regardless of the carbohydrate source, was confirmed by an analysis of the features and characteristics of CDs nanoparticles. N-doped CDs with increased fluorescence were also created at the same time using a similar hydrothermal technique, and their photocatalytic activity was investigated. A Life Cycle Assessment (LCA) was conducted for both syntheses with the goal of comparing the environmental effects of the synthesis from commercial xylose to the synthesis from biomass. It was revealed that, although energy is the primary driver of both synthesis pathways' effect categories, the fundamental variations that seem to determine their relative sustainability are connected to the nature of the carbon precursor. Regarding the latter, it is determined that electricity has the greatest environmental impact.
Open Access
Multifunctionalized carbon dots as an active nanocarrier for drug delivery to the glioblastoma cell line
(American Chemical Society, 2024) Algarra González, Manuel; Soto, Juan; Pino-González, María Soledad; González-Muñoz, Elena; Dučić, Tanja; Institute for Advanced Materials and Mathematics - INAMAT2; Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
Nanoparticle-based nanocarriers represent a viable alternative to conventional direct administration in cancer cells. This advanced approach employs the use of nanotechnology to transport therapeutic agents directly to cancer cells, thereby reducing the risk of damage to healthy cells and enhancing the efficacy of treatment. By approving nanoparticle-based nanocarriers, the potential for targeted, effective treatment is greatly increased. The so-called carbon-based nanoparticles, or carbon dots, have been hydrothermally prepared and initiated by a polymerization process. We synthesized and characterized nanoparticles of 2-acrylamido-2-methylpropanesulfonic acid, which showed biocompatibility with glioblastoma cells, and further, we tested them as a carrier for the drug riluzole. The obtained nanoparticles have been extensively characterized by techniques to obtain the exact composition of their surface by using Fourier transform infrared (FTIR), X-ray photoelectron spectroscopy (XPS), and nuclear magnetic resonance (NMR) spectroscopy, as well as cryo-transmission electron microscopy. We found that the surface of the synthesized nanoparticles (NPs) is covered mainly by sulfonated, carboxylic, and substituted amide groups. These functional groups make them suitable as carriers for drug delivery in cancer cells. Specifically, we have successfully utilized the NPs as a delivery system for the drug riluzole, which has shown efficacy in treating glioblastoma cancer cells. The effect of nanoparticles as carriers for the riluzole system on glioblastoma cells was studied using live-cell synchrotron-based FTIR microspectroscopy to monitor in situ biochemical changes. After applying nanoparticles as nanocarriers, we have observed changes in all biomacromolecules, including the nucleic acids and protein conformation. These findings provide a strong foundation for further exploration into the development of targeted treatments for glioblastoma.
Open Access
Recent developments in the use of carbon-based nanomaterials in cancer therapy
(Elsevier, 2025-10-10) Algarra González, Manuel; Vinacua, Sara; Gil-Korilis, Adrián; Gil Bravo, Antonio; Ciencias; Zientziak; Institute for Advanced Materials and Mathematics - INAMAT2; Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa; Gobierno de Navarra / Nafarroako Gobernua
Cancer is one of the most complex health problems worldwide, demanding innovative approaches to achieve effective diagnosis, treatment and prevention. The field of nanomedicine, including nanomaterials and particularly carbon-based nanoparticles, has emerged as a promising candidate to transform cancer therapy. This review presents a landscape of carbon nanomaterial- and nanoparticle-based cancer interventions. First, a brief overview of the types of nanomaterials available is provided, including metal-based nanomaterials, mesoporous silicas, polymers and composites (most notably MXenes and metal-organic frameworks), proteins, and carbon-based nanomaterials, including carbon quantum dots. The latter have attracted significant attention due to their exceptional biocompatibility, tunable surface chemistry, and distinctive optical properties, making them ideal candidates for cancer diagnostic and therapeutic strategies. The second part of this review focuses on briefly presenting the various therapies developed with carbon-based nanomaterials including chemo, radio, immuno, targeted, hyperthermia, photodynamic, and photothermal therapies.

Algarra González, Manuel

Email Address

person.page.identifierURI

Birth Date

Job Title

Last Name

First Name

person.page.departamento

person.page.instituteName

ORCID

person.page.observainves

person.page.upna

Name

Filters

Author

Subject

Date

Has files

Item Type

Type

Settings

Sort By

Results per page

Search Results