Person:
Sánchez Villegas, María Almudena

person.page.identifierURI

https://academica-e.unavarra.es/handle/2454/49971

Last Name

Sánchez Villegas

First Name

María Almudena

person.page.departamento

Ciencias de la Salud

person.page.instituteName

IS-FOOD. Research Institute on Innovation & Sustainable Development in Food Chain

ORCID

0000-0001-7733-9238

person.page.upna

812351

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Now showing 1 - 10 of 11

Open Access
SESSAMO, follow-up of secondary students to assess mental health and obesity: a cohort study
(Elsevier, 2024) Goñi Sarriés, Adriana; Pírez, Guillermo; Yárnoz-Goñi, Nora; Lahortiga Ramos, Francisca; Iruin, Álvaro; Díez-Suárez, Azucena; Zorrilla, Iñaki; Morata-Sampaio, Leticia; Oliver, M. Jesús; González Pinto, Ana; Sánchez Villegas, María Almudena; Ciencias de la Salud; Osasun Zientziak; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD
During last decades, a departure from health-related lifestyles has been observed among adolescents. Evidence reports that healthy lifestyles could be predictors of better mental health status. The aims of the SESSAMO Project are: 1) to assess the association between lifestyles and physical and mental health; 2) to assess how self-concept and stressful life events can modulate these associations; and 3) to establish the role of social determinants in the lifestyle and in adolescents¿ health. The SESSAMO Project is a prospective cohort carried out in Spain. Students aged 14-16 years (2nd-4th ESO) and their parents are invited to participate. Baseline data are collected through on-line, validated, self-administered questionnaires through a digital platform. Information on lifestyles, stressful life events and self-concept are collected. Screening of depression, anxiety, eating disorders, suicide risk, psychotic experiences and COVID impact is assessed. Every three years, up to age of 25, participants will be contacted again to update relevant information.
Open Access
The risk of incident depression when assessed with the lifestyle and well-being index
(Elsevier, 2023) Pano, O.; Sayón-Orea, Carmen; Hershey, María Soledad; O, Víctor de la; Fernández-Lázaro, César; Bes-Rastrollo, Maira; Martín-Moreno, José M.; Sánchez Villegas, María Almudena; Martínez Hernández, J. Alfredo; Ciencias de la Salud; Osasun Zientziak; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD; Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
Objectives: Novel findings indicate links between unhealthy lifestyles and depression based on active inflammatory processes. Thus, identifying participants with poor habits could reveal differences in trends of incident depression. This study aimed to examine the association between an objective lifestyle assessment, as measured by the Lifestyle and Well-Being Index (LWB-I), and incident depression in healthy participants of a Spanish cohort. Study design: This was a longitudinal analysis of a subsample of 10,063 participants from the Seguimiento Universidad de Navarra cohort study. Methods: Group comparisons and Cox proportional hazard models were conducted using the LWB-I, which categorizes the sample into groups with healthy and unhealthy lifestyles and well-being. The main outcome was incident depression as well as secondary outcomes. Results: Those classified to the transition category of LWB-I were associated with a hazard ratio of 0.67 (95% confidence interval: 0.52-0.87), and those in the excellent category showed a hazard ratio of 0.44 (95% confidence interval: 0.33-0.58), which in both groups reflects a significantly lower risk of incident depression compared with the group including those classified in the poor LWB-I level. Moreover, the available sensitivity analyses concerning time of depression diagnosis or antidepressant treatment further supported the role of nutrition and physical activity on incident depression. Interestingly, throughout the follow-up, incident depression was inversely related to healthier daily habits as measured by the LWB-I. Conclusions: A global assessment of lifestyles such as the LWB-I provides valuable insight into the complex relationship between lifestyle factors and their link to depression risk.
Open Access
Health-related quality of life and mortality in the 'Seguimiento Universidad de Navarra' prospective cohort study
(Elsevier, 2023) López-Herreros, J.; Martínez González, Miguel Ángel; Gea, A.; Sánchez Villegas, María Almudena; Dierssen Sotos, Trinidad; Jiménez-Moleón, J. J.; Ruiz Canela, Miguel; Toledo, Estefanía; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD
Objective: To study the association between health-related quality of life (HRQoL) and all-cause mortality in a healthy middle-aged Mediterranean cohort. Methods: We included 15,390 participants –mean age 42.8 years at first HRQoL ascertainment, all university graduates–. HRQoL was assessed with the self-administered Medical Outcomes Study Short Form-36 (SF-36) twice, with a 4-year gap. We used multivariable-adjusted Cox regression models to address the relation between self-reported health and Physical or Mental Component Summary (PCS-36 or MCS-36) and mortality, and their interaction with prior comorbidities or adherence to the Mediterranean diet (MedDiet). Results: Over 8.7 years of median follow-up time, 266 deaths were identified. Hazard ratio (HR) for the excellent vs. poor/fair category in self-reported health was 0.30 (95 % confidence interval (CI), 0.16–0.57) in the model with repeated measurements of HRQoL. Both the PCS-36 (HRquartile4(Q4)vs.Q1 0.57 [95%CI, 0.36–0.90], ptrend < 0.001; HRper+10points: 0.64 [95%CI, 0.54–0.75]) and the MCS-36 (HRQ4vs.Q1 0.67 [95%CI, 0.46–0.97], ptrend = 0.025; HRper+10points: 0.86 [95%CI, 0.74–0.99]) were inversely associated with mortality in the model with repeated measurements of HRQoL. Previous comorbidities or adherence to the MedDiet did not modify these associations. Conclusions: Self-reported HRQoL –assessed as self-reported health, PCS-36 and MCS-36– obtained with the Spanish version of the SF-36 were inversely associated with mortality risk, regardless of the presence of previous comorbidities or adherence to the MedDiet.
Open Access
Trends in adherence to the mediterranean diet in spanish children and adolescents across two decades
(MDPI, 2023) Herrera-Ramos, Estefanía; Tomaino, Laura; Sánchez Villegas, María Almudena; Ribas-Barba, Lourdes; Gómez, Santiago F.; Wärnberg, Julia; Osés Recalde, Maddi; González Gross, Marcela; Gusi, Narcís; Aznar, Susana; Marín-Cascales, Elena; González Valeiro, Miguel A.; Terrados, Nicolás; Tur, Josep A.; Segú, Marta; Fitó, Montserrat; Homs, Clara; Benavente-Marín, Juan C.; Labayen Goñi, Idoia; Zapico, Augusto G.; Sánchez-Gómez, Jesús; Jiménez-Zazo, Fabio; Alcaraz, Pedro E.; Sevilla-Sánchez, Marta; Pulgar, Susana; Bouzas, Cristina; Sistac-Sorigué, Clara; Schröder, Helmut; Serra-Majem, Lluis; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD
Unhealthy dietary habits determined during childhood may represent a risk factor to many of the chronic non-communicable diseases (NCDs) in adulthood. Mediterranean Diet (MD) adherence in children and adolescents (8–16 years) living in Spain was investigated using the KIDMED questionnaire in a comparative analysis of two cross-sectional nationwide representative studies: enKid (1998–2000, n = 1001) and PASOS (2019–2020, n = 3540). Taking into account the educational level of pupils, as well as the characteristics of the place of living, a significant association was found between a KIDMED score ≥ 8 (optimal MD adherence) and primary education as well as residency in an area of <50,000 inhabitants, while living in the southern regions was associated with non-optimal MD adherence (p < 0.001). Participants of the 2019–2020 study showed an increase in the consumption of dairy products (31.1% increase), pasta/rice (15.4% increase), olive oil (16.9% increase), and nuts (9.7% increase), as well as a decreased sweets and candies intake (12.6% reduction). In contrast, a significantly lower MD adherence was found when comparing the 2019–2020 (mean ± SE: 6.9 ± 0.04) and the 1998–2000 study (7.37 ± 0.08); p < 0.001), due to less consumption of fish (20.3% reduction), pulse (19.4% reduction), and fruits (14.9% reduction), and an increased intake of commercial goods/pastries or fast-food intake (both 19.4% increase). The lowest adherence was recorded for adolescents also in the most recent study, where 10.9% of them presented a KIDMED score ≤ 3. This study shows that eating habits are deteriorating among Spanish children and adolescents. Such findings point out the urgency of undertaking strong measures to promote the consumption of healthy, sustainable, and non-ultra-processed food, such as those available in an MD, not only at a scientific and academic level, but also at a governmental one.
Open Access
Association between adherence to Swedish dietary guidelines and Mediterranean diet and risk of stroke in a Swedish population
(MDPI, 2022) González Padilla, Esther; Tao, Zhen; Sánchez Villegas, María Almudena; Álvarez Pérez, Jacqueline; Borné, Yan; Sonestedt, Emily; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD
Dietary factors associated with stroke risk are still rather unknown. The aim was to examine the association between adherence to healthy dietary patterns and incidence of stroke among 25,840 individuals from the Swedish Malmö Diet and Cancer Study cohort. Dietary data were obtained using a combination of a 7-day food record, diet questionnaire, and interview. A Swedish Dietary Guidelines Score (SDGS), including five dietary components based on the current Swedish dietary guidelines, and a modified Mediterranean diet score (mMDS), composed of ten dietary components, were constructed. Over a mean follow-up period of 19.5 years, 2579 stroke cases, of which 80% were ischaemic, were identified through national registers. Weak, non-significant associations were found between the dietary indices and the risk of stroke. However, after excluding potential misreporters and individuals with unstable food habits (35% of the population), we observed significant inverse association (p-trend < 0.05) between SDGS and mMDS and total and ischaemic stroke (HR per point for total stroke: 0.96; 95% CI: 0.92–1.00 for SDGS and 0.95; 95% CI: 0.91–0.99 for mMDS). In conclusion, high quality diet in line with the current Swedish dietary recommendations or Mediterranean diet may reduce the risk of total and ischaemic stroke.
Open Access
Effect of a dietary intervention based on the mediterranean diet on the quality of life of patients recovered from depression: analysis of the PREDIDEP randomized trial
(Elsevier, 2023) Cabrera Suárez, Beatriz; Lahortiga Ramos, Francisca; Sayón-Orea, Carmen; Hernández-Fleta, José L.; González Pinto, Ana; Molero, Patricio; Vega-Pérez, Rosario; Sánchez Villegas, María Almudena; Cabrera, Claudio; Pla, Jorge; Chiclana Actis, Carlos; Vega-Pérez, P.; Navarro, S.; Ortuño, Felipe; Florido Rodríguez, Mónica; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD
Introduction: There is substantial evidence supporting that improving diet quality leads to improved healthrelated quality of life (HRQoL). Our major aim was to assess the effectiveness of a Mediterranean diet–based nutritional intervention to improve HRQoL in the context of a secondary prevention trial of depression. Secondarily to assess its effectiveness among adults aged 60 or more years. Methods: The PREDIDEP study is a 2-year multicentre, randomized, single-blinded nutritional trial. At baseline and at 1-year and 2-year follow-up, SF-36 health survey questionnaire was collected to evaluate participants' HRQoL (total and specific range for each of the 8 dimensions: 0 to 100 points). Mixed effect linear models were used to assess changes in HRQoL according to adherence to the Mediterranean diet. The trial was registered at ClinicalTrials.gov NCT03081065. Results: After 2 years of intervention, the Mediterranean Diet intervention group compared to control group (without nutritional intervention, only usual clinical care) showed an improvement in some dimensions of HRQoL such as Mental Health (7.22; 95 % CI = 2.22–12.22) (between-group difference: 6.79; 95 % CI − 0.14–13.73, p = 0.055); Vitality (9.51; 95 % CI = 4.00–15.03) (between-group difference: 9.00; 95 % CI 1.75–16.25, p = 0.020); Mental Summary Component (2.83; 95 % CI = 0.55–5.11) (between-group difference: 1.17; 95 % CI = − 1.96–4.30, p = 0.462); and General Health (10.70; 95 % CI = 5.58–15.81) (between-group difference: 6.20; 95 % CI = − 0.89–13.28, p = 0.086). Similar results were observed for participants aged 60 or more years. Conclusion: The intervention based on Mediterranean diet in patients with previous depression seems to be effective in improving HRQoL, especially the mental dimensions. This effect is also observed among participants aged 60 or more years.
Open Access
Mediterranean diet-based intervention to improve depressive symptoms: analysis of the PREDIDEP randomized trial
(Taylor and Francis Group, 2023) Cabrera Suárez, Beatriz; Hernández-Fleta, José L.; Molero, Patricio; González Pinto, Ana; Lahortiga Ramos, Francisca; Cabrera, Claudio; Chiclana Actis, Carlos; Sánchez Villegas, María Almudena; PREDI-DEP investigators; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD
Background:The effect of an intervention based on Mediterranean diet on reducing recurrencerisk or subsyndromal depressive symptoms in recovered depressed patients has not beenexplored.Methods:The PREDIDEP study was a two-year randomized trial designed to assess the effect of theMediterranean Diet enriched with extra virgin olive oil on depression recurrence. At baseline and atfour, eight, 16, 20, and 24 months of follow-up, depressive symptoms were evaluated through theBeck Depression inventory. Cox regression analysis wasfitted to assess the role of dietaryintervention on the risk of depression recurrence. Mixed effects linear models were used toassess changes in depressive subsyndromal symptoms according to the intervention.Results::After two years of intervention, the dietary intervention group (n= 103) compared to thecontrol group (n= 93) showed no differences regarding depression recurrence risk as mainoutcome. As secondary outcomes, an improvement of depressive symptoms was yielded at four(−2.15; 95% CI =−4.00 to−0.29) and eight months (−2.42; 95% CI =−4.17 to−0.67) in theintervention group, with no changes in control group. Moreover, at 20 months, significantdifferences were found between groups (−3.35; 95% CI =−6.08 to−0.61).Conclusions: An intervention with Mediterranean diet in patients with previous depressiveepisodes might contribute to the reduction of depressive subsyndromal symptoms.
Open Access
Effectiveness of a remote nutritional intervention to increase the adherence to the Mediterranean diet among recovered depression patients
(Taylor & Francis, 2022) Cabrera Suárez, Beatriz; Pla, Jorge; González Pinto, Ana; Hernández, José; Chiclana Actis, Carlos; Ortuño, Felipe; Florido Rodríguez, Mónica; Sánchez Villegas, María Almudena; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD; Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
Background: There is substantial evidence supporting that remote interventions are useful to change dietary habits. However, the effect of a remote intervention based on Mediterranean diet (MD) in depressive patients has been less explored. Objective: This study aims to assess the effectiveness of a remotely provided Mediterranean dietbased nutritional intervention in the context of a secondary prevention trial of depression. Methods: The PREDIDEP study was a 2-year multicenter, randomized, single-blinded trial designed to assess the effect of the MD enriched with extra virgin olive oil (EVOO) on the prevention of depression recurrence. The intervention group received usual care for depressed patients and remote nutritional intervention every three months which included phone contacts and webbased interventions; and the control group, usual care. At baseline and at 1-year and 2-year follow-up, the 14-item MD Adherence Screener (MEDAS) questionnaire and a semiquantitative food frequency questionnaire (FFQ) were collected by a dietitian. Mixed effects linear models were used to assess changes in nutritional variables according to the group of intervention. The trial was registered at ClinicalTrials.gov NCT03081065. Results: Compared with control group, the MD intervention group showed more adherence to MD (between-group difference: 2.76; 95% CI 2.13–3.39; p < 0.001); and a healthier diet pattern with a significant increase in the consumption of olive oil (p < 0.001), and a significant reduction in refined cereals (p = 0.031) after 2 years of intervention. Conclusions: The remote nutritional intervention increases adherence to the MD among recovered depression patients. Trial registration: ClinicalTrials.gov identifier: NCT03081065.
Open Access
Sedentary behaviors and risk of depression in the Seguimiento Universidad de Navarra cohort: the SUN Project
(Escola Nacional de Saude Pública Sergio Arouca, 2022) Pimenta, Adriano Marçal; Deus Mendonça, Raquel de; Lahortiga Ramos, Francisca; Fernández-Lázaro, César; Martínez González, Miguel Ángel; Sánchez Villegas, María Almudena; Ciencias de la Salud; Osasun Zientziak; Gobierno de Navarra / Nafarroako Gobernua
The study aimed to prospectively examine the association between different sedentary behaviors and the risk of depression. We included 12,691 Spanish university graduates (mean age: 36.7 year; SD: 11.5), participants of the Seguimiento Universidad de Navarra cohort (the SUN Project), initially free of depression who were followed-up for a median of 10.9 years. Based on items presented in our baseline questionnaire, time spent in four sedentary behaviors (hours/day) were evaluated: overall sitting time; TV-viewing; computer use; and driving. Participants were classified as incident cases of depression if they reported a physician diagnosis of depression in at least one of the follow-up assessments conducted after the first two years of follow-up. Cox regression models were used to assess the relationship between sedentary behaviors and depression. A total of 560 incident cases of depression were identified during follow-up. We found no significant association between overall sitting time, TV-viewing or driving and risk of depression. On the other hand, computer use was directly associated with the risk of developing depression during the follow-up (p-value for trend = 0.020), with the participants in the highest quartile of computer use (3.64 to 10 hours/week) having a higher risk of developing depression (HR = 1.33; 95%CI: 1.05-1.70) than those in the lowest quartile (0 to 0.25 hours/week) after adjusting for potential confounders. Prolonged use of computer was independently associated with an increased risk of developing depression among young middle-aged adult university graduates from a Spanish cohort.
Open Access
Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study
(Public Library of Science, 2022) Martín Peláez, Sandra; Serra-Majem, Lluis; Cano Ibáñez, Noemí; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Corella, Dolores; Lassale, Camille; Martínez, Jose Alfredo; Alonso Gómez, Ángel M.; Wärnberg, Julia; Vioque, Jesús; Romaguera, Dora; López Miranda, José; Estruch, Ramón; Tinahones, Francisco J.; Lapetra, José; Fernández-Aranda, Fernando; Bueno Cavanillas, Aurora; Tur, Josep A.; Martín, Vicente; Pintó, Xavier; Delgado Rodríguez, Miguel; Matía, Pilar; Vidal, Josep; Vázquez, Clotilde; Daimiel, Lidia; Ros, Emilio; Toledo, Estefanía; Nishi, Stephanie K.; Sorli, Jose V.; Malcampo, Mireia; Zulet, María Ángeles; Moreno Rodríguez, Anaí; Cueto Galán, Raquel; Vivancos Aparicio, Diego; Colom, Antoni; García-Rios, Antonio; Casas, Rosa; Bernal López, M. Rosa; Santos Lozano, José Manuel; Vázquez, Zenaida; Gómez-Martínez, Carlos; Ortega Azorín, Carolina; Val, José Luis del; Abete, Itziar; Goikoetxea Bahon, Amaia; Pascual, Elena; Becerra-Tomás, Nerea; Chillarón, Juan J.; Sánchez Villegas, María Almudena; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD
Background Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ¿280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41 ±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). Conclusions Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response.