Person: Ribeiro Fernández, María
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Ribeiro Fernández
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María
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Ciencias de la Salud
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812691
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Publication Open Access Relapse, cognitive reserve and their relationship with cognition in first episode schizophrenia: a 3-year follow-up study(Elsevier, 2023) Sánchez Torres, Ana María; Amoretti, Silvia; Enguita Germán, Mónica; Mezquida, Gisela; Moreno-Izco, Lucía; Panadero-Gómez, Rocío; Rementería, Lide; Toll, Alba; Rodríguez-Jiménez, Roberto; Roldán, Alexandra; Pomarol-Clotet, Edith; Ibáñez, Ángela; Usall, Judith; Contreras, Fernando; Vieta, Eduard; López-Ilundain, José M.; Merchán-Naranjo, Jessica; González Pinto, Ana; Berrocoso, Esther; Bernardo, Miguel; Cuesta, Manuel J.; Forte, María Florencia; González-Díaz, Jairo M.; Parellada, Mara; Abrokwa, Hayford; Segura, María Sans; González, Judtih Selma; Zorrilla, Iñaki; González-Ortega, Itxaso; Legido, Teresa; Mané, Anna; Sanchez-Pastor, Luis; Rentero, David; Sarró, Salvador; García-León, María Ángeles; Butjosa, Anna; Pardo, Marta; Zarzuela, Amalia; Ribeiro Fernández, María; Sáiz-Ruiz, Jerónimo; León-Quismondo, Leticia; Hernández, Miguel; Cámara, Concepción de la; Gutiérrez-Fraile, Miguel; González-Blanco, Leticia; Ciencias de la Salud; Osasun ZientziakSchizophrenia is frequently characterized by the presence of multiple relapses. Cognitive impairments are core features of schizophrenia. Cognitive reserve (CR) is the ability of the brain to compensate for damage caused by pathologies such as psychotic illness. As cognition is related to CR, the study of the relationship between relapse, cognition and CR may broaden our understanding of the course of the disease. We aimed to determine whether relapse was associated with cognitive impairment, controlling for the effects of CR. Ninety-nine patients with a remitted first episode of schizophrenia or schizophreniform disorder were administered a set of neuropsychological tests to assess premorbid IQ, attention, processing speed, working memory, verbal and visual memory, executive functions and social cognition. They were followed up for 3 years (n=53) or until they relapsed (n=46). Personal and familial CR was estimated from a principal component analysis of the premorbid information gathered. Linear mixed-effects models were applied to analyse the effect of time and relapse on cognitive function, with CR as covariate. Patients who relapsed and had higher personal CR showed less deterioration in attention, whereas those with higher CR (personal and familial CR) who did not relapse showed better performance in processing speed and visual memory. Taken together, CR seems to ameliorate the negative effects of relapse on attention performance and shows a positive effect on processing speed and visual memory in those patients who did not relapse. Our results add evidence for the protective effect of CR over the course of the illness.Publication Open Access Individual trajectories of cognitive performance in first episode psychosis: a 2-year follow-up study(Springer, 2018) Sánchez Torres, Ana María; Moreno-Izco, Lucía; Lorente Omeñaca, Ruth; Cabrera, Bibiana; Lobo, Antonio; González Pinto, Ana; Merchán-Naranjo, Jessica; Corripio, Iluminada; Vieta, Eduard; Serna, Elena de la; Butjosa, Anna; Contreras, Fernando; Sarró, Salvador; Mezquida, Gisela; Ribeiro Fernández, María; Bernardo, Miguel; Cuesta, Manuel J.; PEPs Group; Ciencias de la Salud; Osasun ZientziakIndividual changes over time in cognition in patients with psychotic disorders have been studied very little, especially in the case of frst episode psychosis (FEP). We aimed to establish whether change in individual trajectories in cognition over 2 years of a sample of 159 FEP patients was reliable and clinically signifcant, using the reliable change index (RCI) and clinically signifcant change (CSC) methods. We also studied a sample of 151 matched healthy controls. Patients and controls were assessed with a set of neuropsychological tests, as well as premorbid, clinical and functionality measures. We analysed the course of cognitive measures over time, using analysis of variance, and the individual trajectories in the cognitive measures with the regression-based RCI (RCISRB) and the CSC. The RCISRB showed that between 5.4 and 31.2% of the patients showed deterioration patterns, and between 0.6 and 8.8% showed improvement patterns in these tests over time. Patients showing better cognitive profles according to RCISRB (worsening in zero to two cognitive measures) showed better premorbid, clinical and functional profles than patients showing deterioration patterns in more than three tests. When combining RCISRB and CSC values, we found that less than 10% of patients showed improvement or deterioration patterns in executive function and attention measures. These results support the view that cognitive impairments are stable over the frst 2 years of illness, but also that the analysis of individual trajectories could help to identify a subgroup of patients with particular phenotypes, who may require specifc interventions.Publication Open Access Motor abnormalities and cognitive impairment in first-episode psychosis patients, their unaffected siblings and healthy controls(Elsevier, 2018) Cuesta, Manuel J.; Moreno-Izco, Lucía; Ribeiro Fernández, María; López-Ilundain, José M.; Lecumberri Villamediana, Pablo; Cabada Giadás, María Teresa; Lorente Omeñaca, Ruth; Sánchez Torres, Ana María; Gómez Fernández, Marisol; Peralta Martín, Víctor; Ciencias de la Salud; Osasun Zientziak; Matemáticas; MatematikaMotor abnormalities (MAs) may be already evidenced long before the beginning of illness and are highly prevalent in psychosis. However, the extent to which the whole range of MAs are related to cognitive impairment in psychosis remains understudied. This study aimed to examine comparatively the relationships between the whole range of motor abnormalities and cognitive impairments in the first-episode of psychosis (FEP), their unaffected siblings and healthy control subjects. Fifty FEP patients, 21 of their healthy siblings and 24 age- and sex matched healthy controls were included. Motor assessment included catatonic, extrapyramidal and neurological soft signs (NSS) by means of standardized instruments. An exhaustive neuropsychological battery was also performed to extract the 7 cognitive dimensions of MATRICS initiative. Higher scores on NSS but not on extrapyramidal and catatonic signs showed significant associations with worse cognitive performance in the three study groups. However, the pattern of associations regarding specific cognitive functions was different among the three groups. Moreover, extrapyramidal signs showed significant associations with cognitive impairment only in FEP patients but not in their unaffected siblings and healthy controls. Catatonic signs did not show any significant association with cognitive functioning in the three study groups. These findings add evidence to the associations between motor abnormalities, particularly NSS and extrapyramidal signs, and cognitive impairment in first-episode psychosis patients. In addition, our results suggest that the specific pattern of associations between MAs and cognitive functioning is different in FEP patients from those of the unaffected siblings and healthy subjects.