Open Access
Epidemiological study and genetic characterization of inherited muscle diseases in a northern Spanish region
(BioMed Central, 2019) Pagola Lorz, María Inmaculada; Vicente Cemborain, Esther; Ibáñez Beroiz, Berta; Torné, Laura; Elizalde Beiras, Itsaso; García Solaesa, Virginia; González García, Fermín María; Delfrade Osinaga, J.; Jericó Pascual, Ivonne; Ciencias de la Salud; Osasun Zientziak; Gobierno de Navarra / Nafarroako Gobernua
Background: Inherited muscle diseases are a group of rare heterogeneous muscle conditions with great impact on quality of life, for which variable prevalence has previously been reported, probably due to case selection bias. The aim of this study is to estimate the overall and selective prevalence rates of inherited muscle diseases in a northern Spanish region and to describe their demographic and genetic features. Retrospective identification of patients with inherited muscle diseases between 2000 and 2015 from multiple data sources. Demographic and molecular data were registered. Results: On January 1, 2016, the overall prevalence of inherited muscle diseases was 59.00/ 100,000 inhabitants (CI 95%; 53.35-65.26). Prevalence was significantly greater in men (67.33/100,000) in comparison to women (50.80/100,000) (p = 0.006). The highest value was seen in the age range between 45 and 54 (91.32/100,000) years. Myotonic dystrophy type 1 was the most common condition (35.90/100,000), followed by facioscapulohumeral muscular dystrophy (5.15/100,000) and limb-girdle muscular dystrophy type 2A (2.5/100,000). Conclusions: Prevalence of inherited muscle diseases in Navarre is high in comparison with the data reported for other geographical regions. Standard procedures and analyses of multiple data sources are needed for epidemiological studies of this heterogeneous group of diseases.
Open Access
Clinical features and incidence trends of amyotrophic lateral sclerosis in Navarre, Spain, 2007-2018: a population-based study
(Taylor & Francis, 2021) Jericó Pascual, Ivonne; Elizalde Beiras, Itsaso; Pagola Lorz, María Inmaculada; Torné, Laura; Galbete Jiménez, Arkaitz; Delfrade Osinaga, J.; Vicente Cemborain, Esther; Osasun Zientziak; Institute of Smart Cities - ISC; Ciencias de la Salud
Objective: Amyotrophic Lateral Sclerosis (ALS) is a heterogeneous neurodegenerative disorder with a median survival of 3 years. The aim of our study is to analyze the incidence, age-related phenotype and clinical onset, geographical distribution, survival and diagnostic delay of ALS in Navarre. Methods: This is a population-based observational retrospective study, including all residents of Navarre (a northern Spanish region) from 2007 to 2018, who were followed until 30th September 2020. Results: We observed a global incidence 2.47/100,000 person-years, with an upward trend throughout the study, with the highest being in the age group of 70¿74 years old. Point prevalence in December 2018 was 6.64/100,000 inhabitants (95%CI: 4.52¿8.45). Upper limbs weakness onset was the most frequent in young people (<60 years), and bulbar, lower limbs weakness, generalized and respiratory associated with older age. Bulbar phenotype is the most frequent in women and in 80+ group. The median survival from clinical onset was 27.7 months (95%CI: 24.0¿31.4), higher in spinal phenotype and younger onset age, and the diagnosis delay was 10.0 months (95%CI: 8.9¿11.2) from clinical onset. Conclusions: We have observed a trend of increasing incidence in older people where the bulbar phenotype and female predominance. © 2021 World Federation of Neurology on behalf of the Research Group on Motor Neuron Diseases.
Open Access
Lessons learned from the COVID-19 pandemic on the global health needs of young children: a cross-sectional study
(Gobierno de Navarra, 2025-01-31) Elizalde Beiras, Itsaso; López de Dicastillo Sáinz de Murieta, Olga; Andueza-Wood, Hazel Helen; Sola Cía, Sara; Lozano-Ochoa, Cristina; Mujika Zabaleta, Agurtzane; Hernantes Colias, Naia; Pereda Goikoetxea, Beatriz; Antoñanzas Baztán, Elena; Pumar Méndez, María Jesús; Ciencias de la Salud; Osasun Zientziak; Gobierno de Navarra / Nafarroako Gobernua
Fundamento. Este estudio transversal tiene como objetivo eva-luar las necesidades globales de salud de la población infantil de 2 a 6 años y determinar si las características sociodemográficas producen diferencias en las necesidades de salud de los niños observadas después de la pandemia de COVID-19.Métodos. Estudio transversal realizado en tres regiones del nor-te de España con ingresos similares. Los participantes se selec-cionaron mediante muestreo cluster de un paso. El cuestionario auto respondido por los padres Necesidades de salud de la Pobla-ción Infantil evaluó las necesidades de salud mediante siete di-mensiones y 125 ítems.Resultados. Un total de 301 progenitores/cuidadores completa-ron el cuestionario. Las dimensiones autoeficacia parental, aseso-ramiento profesional, aspectos socioemocionales del niño e influencia situacional alcanzaron las puntuaciones más altas, mientras que aspectos socioemocionales de los padres, estilo de vida, promoción de estilos de vida saludables e influencia de personas significativas re-cibieron las puntuaciones más bajas (mayores necesidades). Las necesidades relacionadas con el estilo de vida se vieron afecta-das por la falta de acceso a profesionales de la salud y con mayor intensidad cuando los niños tenían una discapacidad.Conclusiones. El resultado de este estudio podría enriquecer la planificación de estrategias, programas e intervenciones para pro-mover la salud infantil, cubriendo las necesidades identificadas.
Open Access
HIV Incidence Among Women in Sub-Saharan Africa: a time trend Aanalysis of the 2000-2017 Period
(Wolters Kluwer Health, 2021) Soto Ruiz, María Nelia; Arregui Azagra, Adriana; San Martín Rodríguez, Leticia; Elizalde Beiras, Itsaso; Saralegui Gainza, Amaia; Escalada Hernández, Paula; Ciencias de la Salud; Osasun Zientziak; Institute of Smart Cities - ISC
ABSTRACT: The aim of this study was to use data from the United Nations Global Indicators Database to analyze the trends in the HIV incidence rate among women in sub-Saharan African countries between 2000 and 2017. The HIV incidence rate is defined as the number of new HIV infections per 1,000 uninfected population, aged 15 to 49 years old. Joinpoint regression analysis was applied to identify periods when there were significant changes in the HIV incidence rate. The results show that there was a global decrease trend in the HIV incidence rates among women in sub-Saharan Africa, decreasing in all sub-Saharan African countries, except in Angola, Equatorial Guinea, and Sudan, which have remained the same, and Madagascar, where the overall trend is increasing. The joinpoint regression statistical method offers an in-depth analysis of the incidence of HIV among women in sub-Saharan Africa. Copyright © 2021 Association of Nurses in AIDS Care.

Elizalde Beiras, Itsaso

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