Guillén Grima, Francisco
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Guillén Grima
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Francisco
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Ciencias de la Salud
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Publication Open Access Trends in hospital morbidity from Alzheimer's disease in the European Union, 2000-2014(SAGE, 2018) Niu, Hao; Álvarez Álvarez, Ismael; Aguinaga Ontoso, Inés; Guillén Grima, Francisco; Ciencias de la Salud; Osasun ZientziakBackground: Alzheimer’s disease (AD) has become a concerning public health issue. We aimed to analyse the trends of hospital morbidity from AD in the European Union (EU) in the period 2000-2014. Methods: Data from hospital discharges of men and women over 50 years old hospitalised from AD in the EU were extracted from Eurostat database. We tested for secular trends computing the annual percent change, and identifying significant changes in the linear slope of the trend. Results: Hospital morbidity from AD showed a 0.8% (95% confidence intervals -2.2, 0.6) slight declining trend in the EU. In men and women, we recorded a -0.5% and -1.0% decrease in hospital morbidity rates, respectively. Several countries showed changing trends during the study period. Conclusion: AD hospital morbidity has slightly declined in the entire EU in the past years. Eastern European countries showed steadily increasing trends, whereas in western and Mediterranean countries rates decreased or levelled off.Publication Open Access Infant mortality in the European Union: a time trend analysis of the 1994-2015 period(Elsevier España, 2019) Onambele, Luc; San Martín Rodríguez, Leticia; Niu, Hao; Álvarez Álvarez, Ismael; Arnedo Pena, Alberto; Guillén Grima, Francisco; Aguinaga Ontoso, Inés; Ciencias de la Salud; Osasun ZientziakIntroducción: La mortalidad infantil es un indicador de la salud infantil y una variable explicativa del desarrollo socioeconómico. Nuestro objetivo fue examinar los cambios y tendencias de la mortalidad infantil en la Unión Europea (UE) y sus 28 países miembros en el período 1994-2015. Métodos: Se recopilaron datos de muertes de niños menores de un año entre 1994 y 2015 de la base de datos Eurostat. Estudiamos las tendencias en la UE, por países y regiones, utilizando elanálisis de regresión joinpoint. Se condujeron análisis adicionales para estudiar las tendencias de mortalidad neonatal y neonatal precoz. Resultados: La mortalidad infantil en la UE ha disminuido significativamente de 8.3 a 3.6 por 1.000 (porcentaje de cambio anual = −3.8%, intervalos de confianza del 95% −4.1; −3.6). Las tasas de mortalidad más altas se registraron en Rumanía y Bulgaria, y las tasas más bajas en países escandinavos (Finlandia, Suecia). Se encontraron tendencias descendentes significativas en los países de la UE, más pronunciadas en los países bálticos exsoviéticos y países de Europa oriental, mientras que los países de Europa occidental mostraron los descensos menos pronunciados. La mortalidad infantil ha aumentado significativamente en Grecia en los últimos años,mientras que en el Reino Unido e Irlanda las tasas se han estabilizado. Conclusiones: La mortalidad infantil ha disminuido en la UE y sus países en las últimas décadas, más pronunciadamente en los países de Europa oriental y los países bálticos exsoviéticos, mientras que en varios países de Europa occidental las tasas aumentaron o se han estabilizado enlos últimos años.Publication Open Access Trends of mortality from Alzheimer's disease in the European Union, 1994-2013(Wiley, 2017) Niu, Hao; Álvarez Álvarez, Ismael; Guillén Grima, Francisco; Jamal Saad Al-Rahamneh, Moad; Aguinaga Ontoso, Inés; Ciencias de la Salud; Osasun ZientziakBackground: In many countries, Alzheimer’s disease (AD) has gradually become a relevant disease in elderly populations. The aim of this study was to analyse trends of mortality caused by AD in the 28 member countries in the European Union (EU) over the last two decades. Methods: We extracted data for AD deaths for the period 1994-2013 in the EU from the Eurostat and World Health Organization database. Age-standardised mortality rates per 100,000 were computed. Joinpoint regression was used to analyse the trends and compute the annual percent change (APC) in the EU as a whole and by country. Analyses by gender and by European regions were conducted. Results: Throughout the study period, mortality from AD has risen in the EU. Most of the countries showed upward trends, with the sharpest increases in Slovakia, Lithuania and Romania. In men and women, we recorded a 4.7% and 6.0% statistically significant increase in mortality rates in the whole EU, respectively. Several countries showed changing trends during the study period. According to the regional analysis, Northern and Eastern countries showed the steepest increases, while in the latter years in Western countries mortality has declined. Conclusions: Our findings provide evidence that AD mortality has increased in the EU, especially in Eastern and Northern European countries and in the female population. Our results could be a reference for the development of primary prevention policies.