Person: Guillén Grima, Francisco
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Guillén Grima
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Francisco
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Ciencias de la Salud
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0000-0001-9749-8076
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Publication Open Access Infant mortality in the European Union: a time trend analysis of the 1994-2015 period(Elsevier España, 2019) Onambele, Luc; San Martín Rodríguez, Leticia; Niu, Hao; Álvarez Álvarez, Ismael; Arnedo Pena, Alberto; Guillén Grima, Francisco; Aguinaga Ontoso, Inés; Ciencias de la Salud; Osasun ZientziakIntroducción: La mortalidad infantil es un indicador de la salud infantil y una variable explicativa del desarrollo socioeconómico. Nuestro objetivo fue examinar los cambios y tendencias de la mortalidad infantil en la Unión Europea (UE) y sus 28 países miembros en el período 1994-2015. Métodos: Se recopilaron datos de muertes de niños menores de un año entre 1994 y 2015 de la base de datos Eurostat. Estudiamos las tendencias en la UE, por países y regiones, utilizando elanálisis de regresión joinpoint. Se condujeron análisis adicionales para estudiar las tendencias de mortalidad neonatal y neonatal precoz. Resultados: La mortalidad infantil en la UE ha disminuido significativamente de 8.3 a 3.6 por 1.000 (porcentaje de cambio anual = −3.8%, intervalos de confianza del 95% −4.1; −3.6). Las tasas de mortalidad más altas se registraron en Rumanía y Bulgaria, y las tasas más bajas en países escandinavos (Finlandia, Suecia). Se encontraron tendencias descendentes significativas en los países de la UE, más pronunciadas en los países bálticos exsoviéticos y países de Europa oriental, mientras que los países de Europa occidental mostraron los descensos menos pronunciados. La mortalidad infantil ha aumentado significativamente en Grecia en los últimos años,mientras que en el Reino Unido e Irlanda las tasas se han estabilizado. Conclusiones: La mortalidad infantil ha disminuido en la UE y sus países en las últimas décadas, más pronunciadamente en los países de Europa oriental y los países bálticos exsoviéticos, mientras que en varios países de Europa occidental las tasas aumentaron o se han estabilizado enlos últimos años.Publication Open Access Trends in hospital morbidity from Alzheimer's disease in the European Union, 2000-2014(SAGE, 2018) Niu, Hao; Álvarez Álvarez, Ismael; Aguinaga Ontoso, Inés; Guillén Grima, Francisco; Ciencias de la Salud; Osasun ZientziakBackground: Alzheimer’s disease (AD) has become a concerning public health issue. We aimed to analyse the trends of hospital morbidity from AD in the European Union (EU) in the period 2000-2014. Methods: Data from hospital discharges of men and women over 50 years old hospitalised from AD in the EU were extracted from Eurostat database. We tested for secular trends computing the annual percent change, and identifying significant changes in the linear slope of the trend. Results: Hospital morbidity from AD showed a 0.8% (95% confidence intervals -2.2, 0.6) slight declining trend in the EU. In men and women, we recorded a -0.5% and -1.0% decrease in hospital morbidity rates, respectively. Several countries showed changing trends during the study period. Conclusion: AD hospital morbidity has slightly declined in the entire EU in the past years. Eastern European countries showed steadily increasing trends, whereas in western and Mediterranean countries rates decreased or levelled off.Publication Open Access Influence of type of uniform and days of usage in microbiological contamination of nurses uniform in a university hospital(BioMed Central, 2011) Guillén Grima, Francisco; Aguinaga Pérez, A.; Núñez Córdoba, J.; Sara, C.; Ciencias de la Salud; Osasun ZientziakNurse uniforms can act as a reservoir of infections, with the areas around the pockets, cuffs and aprons the most contaminated. The aim of this study is compare the contamination of Standard nurse’s uniform consisted of a dress, pinafore apron with the “scrub dress” type of uniform, as well as to measure the influence of the number of shifts as uniform was used in its contamination.Publication Open Access Normative misperceptions of tobacco use among university students in seven European countries: baseline findings of the 'Social Norms Intervention for the prevention of Polydrug usE' study(Elsevier, 2015) Pischke, Claudia R.; Helmer, Stefanie M.; McAlaney, John; Bewick, Bridgette M.; Guillén Grima, Francisco; Ciencias de la Salud; Osasun ZientziakIntroduction: Research conducted in North America suggests that students tend to overestimate tobacco use among their peers. This perceived norm may impact personal tobacco use. It remains unclear how these perceptions influence tobacco use among European students. The two aims were to investigate possible self-other discrepancies regarding personal use and attitudes towards use and to evaluate if perceptions of peer use and peer approval of use are associated with personal use and approval of tobacco use. Methods: The EU-funded 'Social Norms Intervention for the prevention of Polydrug usE' study was conducted in Belgium, Denmark, Germany, Slovak Republic, Spain, Turkey and United Kingdom. In total, 4482 students (71% female) answered an online survey including questions on personal and perceived tobacco use and personal and perceived attitudes towards tobacco use. Results: Across all countries, the majority of students perceived tobacco use of their peers to be higher than their own use. The perception that the majority (> 50%) of peers used tobacco regularly in the past two months was significantly associated with higher odds for personal regular use (OR: 2.66, 95% CI: 1.90–3.73). The perception that the majority of peers approve of tobacco use was significantly associated with higher odds for personal approval of tobacco use (OR: 6.49, 95% CI: 4.54–9.28). Conclusions: Perceived norms are an important predictor of personal tobacco use and attitudes towards use. Interventions addressing perceived norms may be a viable method to change attitudes and tobacco use among European students, and may be a component of future tobacco control policy.Publication Open Access Med-health: the Mediterranean health alliance(2016) Guillén Grima, Francisco; Universidad Pública de Navarra / Nafarroako Unibertsitate PublikoaPresentación del proyecto Med-health, de la acción K2, orientado a la formación de gestores de salud pública.Publication Open Access Factores de riesgo cardiovascular en universitarios de primer y tercer año(Sociedad Médica de Santiago, 2017) Morales Illanes, Gladys; Guillén Grima, Francisco; Muñoz Navarro, Sergio; Belmar, Carlos; Schifferli, Ingrid; Ciencias de la Salud; Osasun ZientziakBackground: College students are in a critical stage in their life style due to the transition between high school and university and they may be prone to develop cardiovascular diseases. Aim: To compare the prevalence of cardiovascular risk factors (CVRF) in students from first and third year at the University of La Frontera, Temuco-Chile, according to faculty, gender and socioeconomic status (SES). Material and Methods: Cross-sectional study. Anthropometry, blood pressure, lipid profile, blood glucose, insulin resistance (IR), sedentary lifestyle, tobacco and alcohol consumption were evaluated during 2014 in randomly selected 163 freshmen aged 19.2 ± 1.8 years and 163 third year students aged 21.7 ± 2.5 years (49% females), stratified by faculty, career and gender. Results: 32.4% of students had prehypertension, 30.6% abdominal obesity, 26.3% insulin resistance, 25.7% dyslipidemia and 8.9% metabolic syndrome. Third grade students had higher prevalence of elevated total and LDL cholesterol and higher alcohol consumption, especially among students of middle and high socioeconomic level. Compared with students from the School of Medicine, students from the Education Faculty had 3.9, 3.3 and 2.7 times greater likelihood of being obese, having elevated LDLcholesterol and being smokers, respectively. Women had the highest prevalence of sedentary lifestyles and dyslipidemia. Men had the highest prevalence of prehypertension and smoking. Conclusions: Educational programs are required to promote healthy lifestyles among these students.Publication Open Access Subtipos moleculares del cáncer de mama: implicaciones pronósticas y características clínicas e inmunohistoquímicas(Gobierno de Navarra, 2011) Arrechea Irigoyen, María Asunción; Vicente García, Francisco; Córdoba Iturriagagoitia, Alicia; Ibáñez Beroiz, Berta; Santamaría Martínez, Mercedes; Guillén Grima, Francisco; Ciencias de la Salud; Osasun ZientziakFundamento. Los carcinomas de mama representan un grupo heterogéneo de tumores, tanto en su comportamiento clínico como pronóstico. El objetivo del presente trabajo es clasificar los carcinomas de mama en subtipos moleculares mediante marcadores inmunohistoquímicos y analizar las características clinicopatológicas e inmunohistoquímicas y los patrones de supervivencia y recaída de los distintos subtipos. Material y métodos. Se han clasificado 272 pacientes con diagnóstico de carcinoma de mama en cinco subtipos: carcinomas de mama de tipo basal, de tipo HER2, de tipo luminal A, de tipo luminal B y normal. Resultados. Los carcinomas de mama más frecuentes fueron los de tipo luminal A (62,5%), carcinomas de tipo luminal B (18%), carcinomas de tipo HER2 (9,9%), carcinomas de tipo basal (8,4%) y los de fenotipo normal (1,4%). Los carcinomas de mama de tipo luminal mostraron ser, con mayor frecuencia, de forma significativa, tumores bien diferenciados, de pequeño tamaño tumoral, con ganglios axilares negativos, estadio precoz en el momento del diagnóstico, niveles altos de BCL-2 y bajo índice de proliferación con Ki-67. En cambio, los carcinomas de mama de tipo basal y HER2 presentaban tumores de mayor tamaño, pobremente diferenciados, mayor compromiso ganglionar y estadios más avanzados en el momento del diagnóstico. Expresaban con mayor frecuencia índices de proliferación altos con Ki 67 y fueron los subtipos que en curvas de supervivencia global y de supervivencia libre de progresión mostraron un peor pronóstico. Conclusión. La clasificación del cáncer de mama basada en parámetros inmunohistoquímicos (IHQ) permite una mejor definición pronóstica. Tanto los carcinomas de mama de tipo basal como HER2 presentan características histopatológicas e IHQ más desfavorables así como peor supervivencia y menor tiempo de recaída mientras que los carcinomas de mama de tipo luminal manifiestan características más benignas y mejor pronóstico.Publication Open Access Influencia de las características urbanísticas ambientales en el nivel de actividad física de la población de 18 a 65 años del área metropolitana de Pamplona(Ministerio de Sanidad, Consumo y Bienestar Social, 2016) Orzanco Garralda, María Rosario; Guillén Grima, Francisco; Sáinz Suberviola, María Lourdes; Redín Areta, María Dolores; Rosa Eduardo, Rosanna de la; Aguinaga Ontoso, Inés; Ciencias de la Salud; Osasun ZientziakFundamentos: Un entorno adecuado puede favorecer la práctica de la actividad física, siendo una opción fácil para la población. El objetivo fue determinar la influencia de la percepción de los factores urbanísticos ambientales en el nivel de actividad física de las personas adultas. Métodos: Estudio transversal basado en el International Physical Activity and the Environment Network. Las personas participantes fueron seleccionadas de forma aleatoria y estratificada de la población de las zonas básicas de salud del Área Metropolitana de Pamplona entre las que tenían edad de 18 a 65 años. Se utilizó un cuestionario autoadministrado que incluyó la versión completa de la escala Neighborhood Environment Walkability Scale para valorar la percepción de los factores urbanísticos ambientales y la versión larga del International Physical Activity Questionnaire para recoger datos de actividad física. Se calculó la chi2 y se realizó un análisis multivariable mediante regresión logística no condicional Resultados: Participaron 905 sujetos (54,70% mujeres). Tener sendas de paseo próximas al domicilio o lugar de trabajo se relacionó con practicar actividad física moderada OR: 3,86 (IC 95% 1,70-8,74)] y actividad física total (suma de actividad física vigorosa, moderada y caminar) OR: 2,61 (IC 95% 1,24-5,45)]. La presencia en el barrio de lugares a los que podían ir caminando se asoció con dedicar más tiempo a caminar [OR: 1,26 (IC 95% 1,01-1,58)] y disponer cerca del domicilio o lugar de trabajo de espacios deportivos se asoció conpracticar más actividad física vigorosa [OR: 1,46 (IC 95% 1,01 - 2,12). Conclusiones: Existe asociación directa entre las personas que se declaran más activas y los factores urbanísticos ambientales, como sendas de paseo o instalaciones deportivas.Publication Open Access Relationship between perceived body weight and body mass index based on self- reported height and weight among university students: a cross-sectional study in seven European countries(BioMed Central, 2010) Mikolajczyk, Rafael T.; Maxwell, Annette E.; El Ansari, Walid; Stock, Christiane; Petkeviciene, Janina; Guillén Grima, Francisco; Ciencias de la Salud; Osasun ZientziakBackground: Despite low rates of obesity, many university students perceive themselves as overweight, especially women. This is of concern, because inappropriate weight perceptions can lead to unhealthy behaviours including eating disorders. Methods: We used the database from the Cross National Student Health Survey (CNSHS), consisting of 5, 900 records of university students from Bulgaria, Denmark, Germany, Lithuania, Poland, Spain and Turkey to analyse differences in perceived weight status based on the question: "Do you consider yourself much too thin, a little too thin, just right, a little too fat or much too fat?". The association between perceived weight and body mass index (BMI) calculated from self-reported weight and height was assessed with generalized non-parametric regression in R library gam. Results: Although the majority of students reported a normal BMI (72-84% of males, 65-83% of females), only 32% to 68% of students considered their weight "just right". Around 20% of females with BMI of 20 kg/m(2) considered themselves "a little too fat" or "too fat", and the percentages increased to 60% for a BMI of 22.5 kg/m(2). Male students rarely felt "a little too fat" or "too fat" below BMI of 22.5 kg/m(2), but most felt too thin with a BMI of 20 kg/m(2). Conclusions: Weight ideals are rather uniform across the European countries, with female students being more likely to perceive themselves as "too fat" at a normal BMI, while male students being more likely to perceive themselves as "too thin". Programs to prevent unhealthy behaviours to achieve ill-advised weight ideals may benefit students.Publication Open Access Coverage and development of specialist palliative care services across the World Health Organization European Region (2005-2012): results from a European Association for Palliative Care Task Force survey of 53 countries(SAGE, 2016) Centeno, Carlos; Lynch, Thomas; Garralda, Eduardo; Carrasco, José Miguel; Guillén Grima, Francisco; Ciencias de la Salud; Osasun ZientziakBackground: The evolution of the provision of palliative care specialised services is important for planning and evaluation. Aim: To examine the development between 2005 and 2012 of three specialised palliative care services across the World Health Organization European Region – home care teams, hospital support teams and inpatient palliative care services. Design and setting: Data were extracted and analysed from two editions of the European Association for Palliative Care Atlas of Palliative Care in Europe. Significant development of each type of services was demonstrated by adjusted residual analysis, ratio of services per population and 2012 coverage (relationship between provision of available services and demand services estimated to meet the palliative care needs of a population). For the measurement of palliative care coverage, we used European Association for Palliative Care White Paper recommendations: one home care team per 100,000 inhabitants, one hospital support team per 200,000 inhabitants and one inpatient palliative care service per 200,000 inhabitants. To estimate evolution at the supranational level, mean comparison between years and European sub-regions is presented. Results: Of 53 countries, 46 (87%) provided data. Europe has developed significant home care team, inpatient palliative care service and hospital support team in 2005–2012. The improvement was statistically significant for Western European countries, but not for Central and Eastern countries. Significant development in at least a type of services was in 21 of 46 (46%) countries. The estimations of 2012 coverage for inpatient palliative care service, home care team and hospital support team are 62%, 52% and 31% for Western European and 20%, 14% and 3% for Central and Eastern, respectively. Conclusion: Although there has been a positive development in overall palliative care coverage in Europe between 2005 and 2012, the services available in most countries are still insufficient to meet the palliative care needs of the population.