Olabarrieta Landa, Laiene
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Olabarrieta Landa
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Laiene
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Ciencias de la Salud
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Publication Open Access A multidimensional approach to assessing factors impacting health-related quality of life after pediatric traumatic brain injury(MDPI, 2023) Steinbuechel, Nicole von; Krenz, Ugne; Bockhop, Fabian; Koerte, Inga; Timmermann, Dagmar; Cunitz, Katrin; Zeldovich, Marina; Andelic, Nada; Rojczyk, Philine; Bonfert, Michaela Veronika; Berweck, Steffen; Kieslich, Matthias; Brockmann, Knut; Roediger, Maike; Lendt, Michael; Buchheim, Anna; Muehlan, Holger; Holloway, Ivana; Olabarrieta Landa, Laiene; Ciencias de la Salud; Osasun ZientziakIn the field of pediatric traumatic brain injury (TBI), relationships between pre-injury and injury-related characteristics and post-TBI outcomes (functional recovery, post-concussion depression, anxiety) and their impact on disease-specific health-related quality of life (HRQoL) are under-investigated. Here, a multidimensional conceptual model was tested using a structural equation model (SEM). The final SEM evaluates the associations between these four latent variables. We retrospectively investigated 152 children (8–12 years) and 148 adolescents (13–17 years) after TBI at the recruiting clinics or online. The final SEM displayed a fair goodness-of-fit (SRMR = 0.09, RMSEA = 0.08 with 90% CI [0.068, 0.085], GFI = 0.87, CFI = 0.83), explaining 39% of the variance across the four latent variables and 45% of the variance in HRQoL in particular. The relationships between pre-injury and post-injury outcomes and between post-injury outcomes and TBI-specific HRQoL were moderately strong. Especially, pre-injury characteristics (children’s age, sensory, cognitive, or physical impairments, neurological and chronic diseases, and parental education) may aggravate post-injury outcomes, which in turn may influence TBI-specific HRQoL negatively. Thus, the SEM comprises potential risk factors for developing negative post-injury outcomes, impacting TBI-specific HRQoL. Our findings may assist healthcare providers and parents in the management, therapy, rehabilitation, and care of pediatric individuals after TBI.Publication Open Access Quality of life after brain injury in children and adolescents (QOLIBRI-KID/ADO)-The first disease-specific self-report questionnaire after traumatic brain injury(MDPI, 2023) Steinbuechel, Nicole von; Zeldovich, Marina; Greving, Sven; Olabarrieta Landa, Laiene; Krenz, Ugne; Timmermann, Dagmar; Koerte, Inga; Bonfert, Michaela Veronika; Berweck, Steffen; Kieslich, Matthias; Brockmann, Knut; Roediger, Maike; Lendt, Michael; Staebler, Michael; Schmidt, Silke; Muehlan, Holger; Cunitz, Katrin; Ciencias de la Salud; Osasun ZientziakThe subjective impact of the consequences of pediatric traumatic brain injury (pTBI) on different life dimensions should be assessed multidimensionally and as sensitively as possible using a disease-specific health-related quality of life (HRQoL) instrument. The development and psychometrics of the first such self-report questionnaire for children and adolescents after TBI are reported here. Focus group interviews with children, adolescents, and their parents, cognitive debriefing, item pool generation and reduction using Delphi expert panels were performed. The resulting version was psychometrically tested on 300 individuals aged 8–17 years. After item reduction based on factor analyses, differential item functioning, reliability, and validity were investigated. The final 35 items were associated with six scales (Cognition, Self, Daily Life and Autonomy, Social Relationships, Emotions, Physical Problems). Internal consistency and construct validity were satisfactory. Health-related Quality of life (HRQoL) was significantly lower in older and in female participants, as well as those with cognitive disabilities, anxiety, depression and post-concussion symptoms, than in comparative groups. The new QOLIBRI-KID/ADO is a comprehensive, multidimensional, reliable, and valid instrument, comparable in content and items to the QOLIBRI adult version. Therefore, disease-specific HRQoL can now be measured across the lifespan and may support the amelioration of treatment, care, rehabilitation, and daily life of children and adolescents after TBI.