Adherence to the Mediterranean diet reduces mortality in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain)

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dc.contributor.authorBuckland, Genevieve
dc.contributor.authorAgudo, Antonio
dc.contributor.authorTravier, Noemie
dc.contributor.authorHuerta, José María
dc.contributor.authorCirera, Lluís
dc.contributor.authorTormo, María José
dc.contributor.authorNavarro, Carmen
dc.contributor.authorChirlaque, María Dolores
dc.contributor.authorMoreno Iribas, Conchi
dc.contributor.authorArdanaz, Eva
dc.contributor.authorBarricarte Gurrea, Aurelio
dc.contributor.authorEtxeberria Andueza, Jaione
dc.contributor.authorMarín, Pilar
dc.contributor.authorQuirós, J. Ramón
dc.contributor.authorRedondo, María Luisa
dc.contributor.authorLarrañaga, Nerea
dc.contributor.authorAmiano, Pilar
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorArriola, Larraitz
dc.contributor.authorBasterretxea, Mikel
dc.contributor.authorSánchez, María José
dc.contributor.authorMolina, Esther
dc.contributor.authorGonzález, Carlos A.
dc.contributor.departmentEstadística e Investigación Operativaes_ES
dc.contributor.departmentEstatistika eta Ikerketa Operatiboaeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernuaes
dc.date.accessioned2018-12-28T09:13:57Z
dc.date.available2018-12-28T09:13:57Z
dc.date.issued2011
dc.description.abstractEpidemiological studies show that adherence to a Mediterranean diet (MD) increases longevity; however, few studies are restricted to Mediterranean populations or explore the effect of a MD pattern that directly incorporates olive oil. Therefore the relationship between adherence to the MD and mortality was studied within the the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain). The EPIC-Spain analysis included 40 622 participants (37·7% males) aged 29–69 years who were recruited from five Spanish regions in 1992–1996. During a mean follow-up of 13·4 years, 1855 deaths were documented: 913 from cancer, 399 from CVD, 425 from other causes and 118 from unknown causes of death. Risk of all-cause and cause-specific mortality was assessed according to the level of adherence to a relative MD (rMED) score, measured using an 18-unit scale incorporating nine selected dietary components. A high compared with a low rMED score was associated with a significant reduction in mortality from all causes (hazard ratio (HR) 0·79; 95% CI 0·69, 0·91), from CVD (HR 0·66; 95% CI 0·49, 0·89), but not from overall cancer (HR 0·92; 95% CI 0·75, 1·12). A 2-unit increase in rMED score was associated with a 6% (P,0·001) decreased risk of all-cause mortality. A high olive oil intake and moderate alcohol consumption contributed most to this association. In this Spanish cohort, following an olive oil-rich MD was related to a significant reduction in all-cause mortality, and reduced the risk of mortality from CVD. These results support the important role that the MD pattern has on reducing mortality in Mediterranean countries.en
dc.description.sponsorshipThe present study was supported by the European Commission (DG-SANCO), the International Agency for Research on Cancer (IARC), the Health Research Funds (FIS) of the Spanish Ministry of Health (grant no. Exp P10710130) from the Instituto de Salud Carlos III; the Spanish Regional Governments of Andalucía, Asturias, Basque Country, Murcia (no. 6236) and Navarra and the Catalan Institute of Oncology, and Red Temática de Investigación Cooperativa en Cáncer (RTICC) (grant no. C03/10, R06/0020).en
dc.format.extent11 p.
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1017/s0007114511002078
dc.identifier.issn0007-1145 (Print)
dc.identifier.issn1475-2662 (Electronic)
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/31868
dc.language.isoengen
dc.publisherCambridge University Pressen
dc.relation.ispartofBritish Journal of Nutrition, (2011), 106, 1581–1591en
dc.relation.publisherversionhttps://doi.org/10.1017/s0007114511002078
dc.rights© The Authors 2011en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectMediterranean dieten
dc.subjectMortalityen
dc.subjectEPIC-Spainen
dc.subjectCohort studiesen
dc.titleAdherence to the Mediterranean diet reduces mortality in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain)en
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication4813a82a-515f-42c9-ab2b-a608839b2eb0
relation.isAuthorOfPublication7770971e-9acf-45ee-bb1a-93bf8b5f1c73
relation.isAuthorOfPublication.latestForDiscovery4813a82a-515f-42c9-ab2b-a608839b2eb0

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