Diagnostic and prognostic potential of multiparametric renal MRI in Kidney transplant patients

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dc.contributor.authorEcheverría Chasco, Rebeca
dc.contributor.authorMartín Moreno, Paloma L.
dc.contributor.authorAramendía Vidaurreta, Verónica
dc.contributor.authorGarcía-Ruiz, Leyre
dc.contributor.authorMora-Gutiérrez, José María
dc.contributor.authorVidorreta Díaz de Cerio, Marta
dc.contributor.authorVillanueva Larre, Arantxa
dc.contributor.authorCano, David
dc.contributor.authorBastarrika, Gorka
dc.contributor.authorFernández Seara, María A.
dc.contributor.departmentIngeniería Eléctrica, Electrónica y de Comunicaciónes_ES
dc.contributor.departmentInstitute of Smart Cities - ISCen
dc.contributor.departmentIngeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzareneu
dc.date.accessioned2024-04-15T15:25:06Z
dc.date.available2024-04-15T15:25:06Z
dc.date.issued2024
dc.date.updated2024-04-15T14:18:00Z
dc.description.abstractBackground: Multiparametric MRI provides assessment of functional and structural parameters in kidney allografts. Itoffers a non-invasive alternative to the current reference standard of kidney biopsy. Purpose: To evaluate the diagnostic and prognostic utility of MRI parameters in the assessment of allograft function in thefirst 3-months post-transplantation. Study Type: Prospective. Subjects: 32 transplant recipients (54 17 years, 20 females), divided into two groups according to estimated glomerularfiltration rate (eGFR) at 3-months post-transplantation: inferior graft function (IGF; eGFR<45 mL/min/1.73 m2,n=10) andsuperior graft function (SGF; eGFR≥45 mL/min/1.73 m2,n=22). Further categorization was based on the need for hemo-dialysis (C1) and decrease in s-creatinine (C2) at 1-week post-transplantation: delayed-graft-function (DGF:n=4 C1,n=10 C2) and early graft-function (EGF:n=28 C1,n=22 C2). Field Strength/Sequence: 3-T, pseudo-continuous arterial spin labeling, T1-mapping, and diffusion-weighted imaging. Assessment: Multiparametric MRI was evaluated at 1-week in all patients and 3-months after transplantation in 28 patients. Renalbloodflow (RBF), diffusion coefficients (ADC,ΔADC,D,ΔD,D*,flowing fractionf),T1andΔT1were calculated in cortex andmedulla. The diagnostic and prognostic value of these parameters, obtained at 3-months and 1-week post-transplantation,respectively, was evaluated in the cortex to discriminate between DGF and EGF, and between SGF and IGF. Statistical Tests: Logistic regression, receiver-operating-characteristics, area-under-the-curve (AUC), confidence intervals(CIs), analysis-of-variance,t-test, Wilcoxon-Mann–Whitney test, Fisher’s exact test, Pearson’s correlation.P-value<0.05 wasconsidered significant. Results: DGF patients exhibited significantly lower cortical RBF and f and higherD*. The diagnostic value of MRI fordetecting DGF was excellent (AUC=100%). Significant differences between patients with IGF and SGF were found inRBF,ΔT1, andΔD. Multiparametric MRI showed higher diagnostic (AUC=95.32%; CI: 88%–100%) and prognostic(AUC=97.47%, CI: 92%–100%) values for detecting IGF than eGFR (AUC=89.50%, CI: 79%–100%). Data Conclusion: Multiparametric MRI may show high diagnostic and prognostic value in transplanted patients, yieldingbetter results compared to eGFR measurements. Level of Evidence: 2. Technical Efficacy: Stage 1.en
dc.description.sponsorshipThis work was funded by Government of Navarra, Grant Num-ber: PC181-182 RM-RENAL. Rebeca Echeverria-Chasco received PhD grant support from Siemens Healthcare Spain.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationEcheverria-Chasco, R., Martin-Moreno, P. L., Aramendía-Vidaurreta, V., Garcia-Ruiz, L., Mora-Gutiérrez, J. M., Vidorreta, M., Villanueva, A., Cano, D., Bastarrika, G., Garcia-Fernandez, N., Fernández-Seara, M. A. (2024) Diagnostic and prognostic potential of multiparametric renal MRI in Kidney transplant patients. Journal of Magnetic Resonance Imaging, 1-14. https://doi.org/10.1002/jmri.29235.en
dc.identifier.doi10.1002/jmri.29235
dc.identifier.issn1053-1807
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/47974
dc.language.isoengen
dc.publisherWileyen
dc.relation.ispartofJournal of Magnetic Resonance Imaging 2024, 1-14en
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//PC181-182 RM-RENAL/
dc.relation.publisherversionhttps://doi.org/10.1002/jmri.29235
dc.rights© 2024 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectArterial spin labelingen
dc.subjectDelayed graft functionen
dc.subjectDiffusion-weighted imagingen
dc.subjectKidney transplanten
dc.subjectT1-mappingen
dc.titleDiagnostic and prognostic potential of multiparametric renal MRI in Kidney transplant patientsen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication5cfc3bb5-70a4-49da-9dcb-ea6cd22e0780
relation.isAuthorOfPublicationd3bfd5bf-8426-455b-bcc4-897ddb0d4c2e
relation.isAuthorOfPublication.latestForDiscoveryd3bfd5bf-8426-455b-bcc4-897ddb0d4c2e

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