Direct functionalization of TiO2/PSS sensing layer for an LMR-based optical fiber reusable biosensor
| dc.contributor.author | Santano Rivero, Desiree | |
| dc.contributor.author | Socorro Leránoz, Abián Bentor | |
| dc.contributor.author | Del Villar, Ignacio | |
| dc.contributor.department | Ingeniería Eléctrica, Electrónica y de Comunicación | es_ES |
| dc.contributor.department | Institute of Smart Cities - ISC | en |
| dc.contributor.department | Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren | eu |
| dc.contributor.funder | Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa, PJUPNA2033 | es |
| dc.date.accessioned | 2023-11-15T14:56:57Z | |
| dc.date.available | 2023-11-15T14:56:57Z | |
| dc.date.issued | 2023 | |
| dc.date.updated | 2023-11-15T14:42:27Z | |
| dc.description.abstract | Functionalization plays a crucial role in the development of biosensors. In this study, bioreceptors were directly immobilized onto the surface of a sensing layer after physical activation, avoiding the need for longer and more complex functionalization systems. This direct immobilization was applied to an optical sensing platform based on lossy mode resonances (LMRs) generated by a thin-film of titanium (IV) dioxide/poly(sodium 4-styrenesulfonate) (TiO 2 /PSS). To generate the LMR, a 200-micron bare optical fiber was coated with TiO 2 /PSS using the layer-by-layer self-assembly technique. The PSS of the sensing layer was then physically activated using either UV-ozone or plasma to immobilize anti-rabbit IgG bioreceptors. This enabled specific and label-free detection of rabbit IgG concentrations ranging from 0.002 to 2 mg/ml. The results presented in this work include real-time detection of rabbit IgG, a comparison between the two activation techniques (UV-ozone and plasma), and an analysis of the biosensor’s reusability over four consecutive cycles, which demonstrates the promising potential of the TiO 2 /PSS sensing layer for biosensing applications. | en |
| dc.description.sponsorship | This work was supported in part by the Spanish Agencia Estatal de Investigación (AEI) under Grant PID2019-106231RB-I00, in part by the Public University of Navarra under Grant PJUPNA2033 and in part by a Ph.D Grant by the Public University of Navarra. | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Santano-Rivero, D., Socorro-Leránoz, A. B., Del-Villar, I. (2023) Direct functionalization of TiO2/PSS sensing layer for an LMR-based optical fiber reusable biosensor. IEEE Sensors Journal, 1-8. https://doi.org/10.1109/JSEN.2023.3328810. | en |
| dc.identifier.doi | 10.1109/JSEN.2023.3328810 | |
| dc.identifier.issn | 1530-437X | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/46780 | |
| dc.language.iso | eng | en |
| dc.publisher | IEEE | en |
| dc.relation.ispartof | IEEE Sensors Journal 2023 | en |
| dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106231RB-I00/ES/ | |
| dc.relation.publisherversion | https://doi.org/10.1109/JSEN.2023.3328810 | |
| dc.rights | This work is licensed under a Creative Commons Attribution 4.0 License. | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Biosensor | en |
| dc.subject | Optical fiber | en |
| dc.subject | Layer-by-layer | en |
| dc.subject | Lossy mode resonance | en |
| dc.subject | TiO2 thin-film | en |
| dc.title | Direct functionalization of TiO2/PSS sensing layer for an LMR-based optical fiber reusable biosensor | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/acceptedVersion | |
| dspace.entity.type | Publication | |
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