Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheep

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dc.contributor.authorSalazar, Eider
dc.contributor.authorMonleón, Eva
dc.contributor.authorBolea, Rosa
dc.contributor.authorAcín, Cristina
dc.contributor.authorPérez, Marta María
dc.contributor.authorÁlvarez, Neila
dc.contributor.authorLeginagoikoa, Iratxe
dc.contributor.authorJuste, Ramón
dc.contributor.authorMinguijón, Esmeralda
dc.contributor.authorReina Arias, Ramsés
dc.contributor.authorGlaría Ezquer, Idoia
dc.contributor.authorBerriatua, Eduardo
dc.contributor.authorAndrés Cara, Damián de
dc.contributor.authorBadiola, Juan José
dc.contributor.authorAmorena Zabalza, Beatriz
dc.contributor.authorLuján, Lluís
dc.contributor.departmentIdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutuaes_ES
dc.date.accessioned2018-11-27T11:22:22Z
dc.date.available2018-11-27T11:22:22Z
dc.date.issued2010
dc.description.abstractThere are few reports on the pathogenesis of scrapie (Sc) and Visna/maedi virus (VMV) coinfections. The aim of this work was to study in vivo as well as post mortem both diseases in 91 sheep. Diagnosis of Sc and VMV infections allowed the distribution of animals into five groups according to the presence (+) or absence ( ) of infection by Sc and VMV: Sc /VMV , Sc /VMV+, Sc+/VMV and Sc+/ VMV+. The latter was divided into two subgroups, with and without VMV-induced lymphoid follicle hyperplasia (LFH), respectively. In both the lung and mammary gland, PrPSc deposits were found in the germinal center of hyperplasic lymphoid follicles in the subgroup of Sc+/VMV+ having VMV-induced LFH. This detection was always associated with (and likely preceded by) PrPSc observation in the corresponding lymph nodes. No PrPSc was found in other VMV-associated lesions. Animals suffering from scrapie had a statistically significantly lower mean age than the scrapie free animals at the time of death, with no apparent VMV influence. ARQ/ARQ genotype was the most abundant among the 91 ewes and the most frequent in scrapie-affected sheep. VMV infection does not seem to influence the scrapie risk group distribution among animals from the five groups established in this work. Altogether, these data indicate that certain VMVinduced lesions can favor PrPSc deposits in Sc non-target organs such as the lung and the mammary gland, making this coinfection an interesting field that warrants further research for a better comprehension of the pathogenesis of both diseases.en
dc.description.sponsorshipThis work has been funded by a grant of Ministerio de Ciencia e Innovación (ref. AGL2007-66874-C04 GAN). E. Salazar was a PhD student funded by grant B073/2006 from Gobierno de Aragón.en
dc.format.extent10 p.
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1051/vetres/2010030
dc.identifier.issn0928-4249 (Print)
dc.identifier.issn1297-9716 (Electronic)
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/31529
dc.language.isoengen
dc.publisherEDP Sciencesen
dc.relation.ispartofVeterinary Research, (2010) 41:58en
dc.relation.publisherversionhttps://doi.org/10.1051/vetres/2010030
dc.rights© The authors, INRA/EDP Sciences, 2010. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial License, which permits unrestricted use, distribution, and reproduction in any noncommercial medium, provided the original work is properly cited.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/
dc.subjectVisna/maedien
dc.subjectScrapieen
dc.subjectSheepen
dc.subjectCoinfectionen
dc.titleDetection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheepen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication5eb332ef-80cd-4c2b-942f-e48c9d3725f2
relation.isAuthorOfPublicationb8d67008-109a-45c4-b632-218257bb3511
relation.isAuthorOfPublication50c83dcd-b739-4348-b0f0-3a230e16c398
relation.isAuthorOfPublication465b6837-c1f0-4390-85fd-9614dc59752d
relation.isAuthorOfPublication.latestForDiscovery5eb332ef-80cd-4c2b-942f-e48c9d3725f2

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