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Ovine TRIM5α can restrict visna/maedi virus

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dc.contributor.authorJauregui, Paulaes_ES
dc.contributor.authorCrespo, Helena
dc.contributor.authorGlaría Ezquer, Idoia
dc.contributor.authorLuján, Lluíses_ES
dc.contributor.authorContreras, A.es_ES
dc.contributor.authorRosati, Sergioes_ES
dc.contributor.authorAndrés Cara, Damián de
dc.contributor.authorAmorena Zabalza, Beatriz
dc.contributor.authorTowers, G. J.es_ES
dc.contributor.authorReina Arias, Ramsés
dc.contributor.departmentIdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutuaes_ES
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua, IIQ14064.RI1es
dc.date.accessioned2019-01-21T13:24:47Z
dc.date.available2019-01-21T13:24:47Z
dc.date.issued2012
dc.description.abstractThe restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5α restored restricted viral DNA synthesis, suggesting a conserved mechanism of restriction. Identification of TRIM5α active molecular species may open new prophylactic strategies against lentiviral infections.en
dc.description.sponsorshipThis work was supported by grants from CICYT (no. AGL2010-22341- C04-01), the Government of Navarra (no. IIQ14064.RI1), the UK Medical Research Centre, and the UK National Institute of Health Research UCL/UCLH Comprehensive Biomedical Research Centre and fellowships from the Spanish Ministry of Science and Innovation (P.J.) and the Wellcome Trust (G.J.T.).en
dc.format.extent6 p.
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1128/jvi.00440-12
dc.identifier.issn0022-538X (Print)
dc.identifier.issn1098-5514 (Electronic)
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/32035
dc.language.isoengen
dc.publisherAmerican Society for Microbiologyen
dc.relation.ispartofJournal of Virology, September 2012 Volume 86 Number 17, p. 9504–9509en
dc.relation.publisherversionhttps://doi.org/10.1128/jvi.00440-12
dc.rights© 2012, American Society for Microbiology. All Rights Reserved.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.subjectTRIM5αen
dc.subjectVisna/maedi virusen
dc.subjectSheepen
dc.subjectGoatsen
dc.titleOvine TRIM5α can restrict visna/maedi virusen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dspace.entity.typePublication
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relation.isAuthorOfPublicationb8d67008-109a-45c4-b632-218257bb3511
relation.isAuthorOfPublication50c83dcd-b739-4348-b0f0-3a230e16c398
relation.isAuthorOfPublication465b6837-c1f0-4390-85fd-9614dc59752d
relation.isAuthorOfPublication5eb332ef-80cd-4c2b-942f-e48c9d3725f2
relation.isAuthorOfPublication.latestForDiscoverye28c17f3-459d-4b77-9d08-2c325e7150da

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