Structural and functional analysis of polyethylene glycol-coated zein nanoparticles

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dc.contributor.authorCalvopiña, Jonathan
dc.contributor.authorRivero Fuente, Pedro J.
dc.contributor.authorMartínez-Ohárriz, María Cristina
dc.contributor.authorPalacio, José F.
dc.contributor.authorÁlvarez Galindo, José Ignacio
dc.contributor.authorEspuelas, Socorro
dc.contributor.authorIrache, Juan M.
dc.contributor.departmentIngenieríaes_ES
dc.contributor.departmentIngeniaritzaeu
dc.contributor.departmentInstitute for Advanced Materials and Mathematics - INAMAT2en
dc.date.accessioned2025-06-26T18:07:41Z
dc.date.available2025-06-26T18:07:41Z
dc.date.issued2025-08-20
dc.date.updated2025-06-26T17:59:52Z
dc.description.abstractThe development of nanoparticles for drug delivery purposes is faced to a number of challenges, including the complexity of an adequate physico-chemical characterization, especially when nanoparticles are functionalized. The aim of this work was to evaluate and characterize the structure and properties of zein nanoparticles (approximately 200 nm) functionalized with polyethylene glycol (PEG 35,000) at different PEG-to-zein ratios. The interaction between PEG and zein, attributed to hydrogen bonding between the amide groups of zein and the hydroxyl groups of PEG, was evidenced by FTIR and further confirmed by 2D-COS spectroscopy. DSC and TGA thermograms demonstrated the role of PEG in improving nanoparticle thermal stability, with PEG-coated nanoparticles exhibiting higher decomposition temperatures and increased PEG content with higher PEG-to-zein ratios. SEM and AFM imaging of nanoparticle thin films confirmed that PEG decoration enhanced wettability and reduced the hydrophobicity of bare zein nanoparticles, consistent with Rose Bengal test results. Additionally, AFM analysis of nanoparticle distribution in a mucin thin film demonstrated that PEG coating improved nanoparticle dispersibility within the mucin matrix, in line with previous studies describing the increased diffusivity and mucus-permeation properties of nanoparticles coated with hydrophilic polymers. In summary, this study highlights the importance of an in-depth analysis of the physicochemical characteristics of nanoparticles, providing valuable structural insights that facilitate optimization and the selection of the most suitable compositions for preclinical development.en
dc.format.mimetypeapplication/pdf
dc.identifier.citationCalvopiña, J., Rivero, P. J., Martínez-Oharriz, M. C., Palacio, J. F., Alvarez Galindo, J. I., Espuelas, S., Irache, J. M. (2025) Structural and functional analysis of polyethylene glycol-coated zein nanoparticles. International Journal of Pharmaceutics, 681, 1-11. https://doi.org/10.1016/j.ijpharm.2025.125828.
dc.identifier.doi10.1016/j.ijpharm.2025.125828
dc.identifier.issn0378-5173
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/54339
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Pharmaceutics 681, 2025, 125828
dc.relation.publisherversionhttps://doi.org/10.1016/j.ijpharm.2025.125828
dc.rights© 2025 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectZeinen
dc.subjectNanoparticlesen
dc.subjectPolyethylene glycolen
dc.subjectCharacterizationen
dc.subjectThin filmen
dc.subjectMucinen
dc.titleStructural and functional analysis of polyethylene glycol-coated zein nanoparticlesen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationccf8da2b-8e86-4e57-835a-358562d70571
relation.isAuthorOfPublication9c80697b-d874-4f91-924e-f03efd35958c
relation.isAuthorOfPublication.latestForDiscoveryccf8da2b-8e86-4e57-835a-358562d70571

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