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Post-entry blockade of small ruminant lentiviruses by wild ruminants

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dc.contributor.authorSanjosé, Leticiaes_ES
dc.contributor.authorCrespo, Helena
dc.contributor.authorBlatti-Cardinaux, Laurees_ES
dc.contributor.authorGlaría Ezquer, Idoia
dc.contributor.authorMartínez Carrasco, Carloses_ES
dc.contributor.authorBerriatua, Eduardoes_ES
dc.contributor.authorAmorena Zabalza, Beatriz
dc.contributor.authorAndrés Cara, Damián de
dc.contributor.authorBertoni, Giuseppees_ES
dc.contributor.authorReina Arias, Ramsés
dc.contributor.departmentIdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutuaes_ES
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua: IIQ010449.RI1es
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua: IIQ14064.RI1es
dc.contributor.funderUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoaes
dc.date.accessioned2016-02-10T09:46:46Z
dc.date.available2016-02-10T09:46:46Z
dc.date.issued2016
dc.description.abstractSmall ruminant lentivirus (SRLV) infection causes losses in the small ruminant industry due to reduced animal production and increased replacement rates. Infection of wild ruminants in close contact with infected domestic animals has been proposed to play a role in SRLV epidemiology, but studies are limited and mostly involve hybrids between wild and domestic animals. In this study, SRLV seropositive red deer, roe deer and mouflon were detected through modified ELISA tests, but virus was not successfully amplified using a set of different PCRs. Apparent restriction of SRLV infection in cervids was not related to the presence of neutralizing antibodies. In vitro cultured skin fibroblastic cells from red deer and fallow deer were permissive to the SRLV entry and integration, but produced low quantities of virus. SRLV got rapidly adapted in vitro to blood-derived macrophages and skin fibroblastic cells from red deer but not from fallow deer. Thus, although direct detection of virus was not successfully achieved in vivo, these findings show the potential susceptibility of wild ruminants to SRLV infection in the case of red deer and, on the other hand, an in vivo SRLV restriction in fallow deer. Altogether these results may highlight the importance of surveilling and controlling SRLV infection in domestic as well as in wild ruminants sharing pasture areas, and may provide new natural tools to control SRLV spread in sheep and goats.en
dc.description.sponsorshipFunded by CICYT (AGL2010-22341-C04-01 and AGL2013-49137-C3-1-R) and Navarra’s Government (IIQ010449.RI1 and IIQ14064.RI1). L. Sanjosé was a FPI fellow of the Spanish MINECO and R. Reina had contracts from the Public University of Navarra and CSIC. The auhors acknowledge support in the publication fee by the CSIC Open Access Publication Support Initiative through its Unit of Information Resources for Research (URICI).en
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1186/s13567-015-0288-7
dc.identifier.issn0928-4249 (Print)
dc.identifier.issn1297-9716 (Electronic)
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/20011
dc.language.isoengen
dc.publisherBioMed Centralen
dc.relation.ispartofVeterinary Research (2016) 47:1en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//AGL2010-22341-C04-01/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//AGL2013-49137-C3-1-R/ES/en
dc.relation.publisherversionhttps://doi.org/10.1186/s13567-015-0288-7
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.en
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.subjectSmall ruminants lentiviruses (SRLV)en
dc.subjectWild ruminantsen
dc.subjectInfectionen
dc.titlePost-entry blockade of small ruminant lentiviruses by wild ruminantsen
dc.typeArtículo / Artikuluaes
dc.typeinfo:eu-repo/semantics/articleen
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dspace.entity.typePublication
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relation.isAuthorOfPublicationb8d67008-109a-45c4-b632-218257bb3511
relation.isAuthorOfPublication465b6837-c1f0-4390-85fd-9614dc59752d
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relation.isAuthorOfPublication5eb332ef-80cd-4c2b-942f-e48c9d3725f2
relation.isAuthorOfPublication.latestForDiscoverye28c17f3-459d-4b77-9d08-2c325e7150da

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