Phenolic composition of artichoke waste and its antioxidant capacity on differentiated Caco-2 cells
| dc.contributor.author | Jiménez Moreno, Nerea | |
| dc.contributor.author | Cimminelli, María José | |
| dc.contributor.author | Volpe Sainz, Francesca | |
| dc.contributor.author | Ansó Blanco, Raúl | |
| dc.contributor.author | Esparza Catalán, Irene | |
| dc.contributor.author | Mármol, Inés | |
| dc.contributor.author | Rodríguez Yoldi, María Jesús | |
| dc.contributor.author | Ancín Azpilicueta, Carmen | |
| dc.contributor.department | Zientziak | eu |
| dc.contributor.department | Institute for Advanced Materials and Mathematics - INAMAT2 | en |
| dc.contributor.department | Ciencias | es_ES |
| dc.date.accessioned | 2020-03-05T12:00:14Z | |
| dc.date.available | 2020-03-05T12:00:14Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Artichoke waste represents a huge amount of discarded material. This study presents the by‐products (bracts, exterior leaves, and stalks) of the 'Blanca de Tudela' artichoke variety as a potential source of phenolic compounds with promising antioxidant properties. Artichoke residues were subjected to different extraction processes, and the antioxidant capacity and phenolic composition of the extracts were analyzed by spectrophotometric methods and high performance liquid chromatography (HPLC) analyses, respectively. The most abundant polyphenols in artichoke waste were chlorogenic acid, luteolin‐7‐O‐rutinoside, and luteolin‐7‐O‐glucoside. Minor quantities of cynarin, luteolin, apigenin‐7‐O‐glucoside, apigenin‐7‐O‐rutinoside, and naringenin‐7‐O-glucoside were also found. The antioxidant activity of the obtained extracts determined by ABTS [2, 2’‐azinobis (3‐ethylbenzothiazoline‐6‐sulphonic acid)], DPPH (2,2‐diphenyl‐1‐pycrilhydracyl), and FRAP (Ferric Ion Reducing Antioxidant Power) was highly correlated with the total concentration of phenolic compounds. Chlorogenic acid, luteolin‐7‐O‐glucoside, and luteolin‐7‐O‐rutinoside, the most abundant compounds in 60% methanol extracts, are the components most responsible for the antioxidant activity of the artichoke waste extracts. The extract with the best antioxidant capacity was selected to assay its antioxidant potential on a model intestinal barrier. This action of the hydroxycinnamic acids on intestinal cells (Caco-2) was confirmed. In summary, artichoke waste may be considered a very interesting ingredient for food functionalization and for therapeutic purposes. | en |
| dc.description.sponsorship | This research was funded by the Spanish Ministry of Economy and Innovation under Grant (SAF2016-75441-R), Aragón Regional Government (B16-17R, Fondos FEDER 'otra manera de hacer Europa'.), CIBERobn under Grant (CB06/ 03/1012) of the Instituto de Salud Carlos III, and SUDOE (Redvalue, SOE1/PI/E0123). | en |
| dc.format.extent | 15 p. | |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.doi | 10.3390/nu11081723 | |
| dc.identifier.issn | 2072-6643 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/36417 | |
| dc.language.iso | eng | en |
| dc.publisher | MDPI | en |
| dc.relation.ispartof | Nutrients, 2019, 11 (8), 1723 | en |
| dc.relation.projectID | info:eu-repo/grantAgreement/ES/1PE/SAF2016-75441-R/ | |
| dc.relation.publisherversion | https://doi.org/10.3390/nu11081723 | |
| dc.rights | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Artichoke waste | en |
| dc.subject | Valorization | en |
| dc.subject | Polyphenols | en |
| dc.subject | Antioxidant capacity | en |
| dc.subject | Caco-2 cells | en |
| dc.title | Phenolic composition of artichoke waste and its antioxidant capacity on differentiated Caco-2 cells | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dspace.entity.type | Publication | |
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