Microfluidic platform using focused ultrasound passing through hydrophobic meshes with jump availability

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dc.contributor.authorKoroyasu, Yusuke
dc.contributor.authorNguyen, Thanh-Vinh
dc.contributor.authorSasaguri, Shun
dc.contributor.authorMarzo Pérez, Asier
dc.contributor.authorEzcurdia Aguirre, Íñigo Fermín
dc.contributor.authorNagata, Yuuya
dc.contributor.authorYamamoto, Tatsuya
dc.contributor.authorNomura, Nobuhiko
dc.contributor.authorHoshi, Takayuki
dc.contributor.authorOchiai, Yoichi
dc.contributor.authorFushimi, Tatsuki
dc.contributor.departmentEstadística, Informática y Matemáticases_ES
dc.contributor.departmentEstatistika, Informatika eta Matematikaeu
dc.contributor.departmentInstitute of Smart Cities - ISCen
dc.date.accessioned2024-05-22T08:57:30Z
dc.date.available2024-05-22T08:57:30Z
dc.date.issued2023
dc.date.updated2024-05-22T08:41:47Z
dc.description.abstractApplications in chemistry, biology, medicine, and engineering require the large-scale manipulation of a wide range of chemicals, samples, and specimens. To achieve maximum efficiency, parallel control of microlitre droplets using automated techniques is essential. Electrowetting-on-dielectric (EWOD), which manipulates droplets using the imbalance of wetting on a substrate, is the most widely employed method. However, EWOD is limited in its capability to make droplets detach from the substrate (jumping), which hinders throughput and device integration. Here, we propose a novel microfluidic system based on focused ultrasound passing through a hydrophobic mesh with droplets resting on top. A phased array dynamically creates foci to manipulate droplets of up to 300 mu L. This platform offers a jump height of up to 10 cm, a 27-fold improvement over conventional EWOD systems. In addition, droplets can be merged or split by pushing them against a hydrophobic knife. We demonstrate Suzuki-Miyaura cross-coupling using our platform, showing its potential for a wide range of chemical experiments. Biofouling in our system was lower than in conventional EWOD, demonstrating its high suitability for biological experiments. Focused ultrasound allows the manipulation of both solid and liquid targets. Our platform provides a foundation for the advancement of micro-robotics, additive manufacturing, and laboratory automation.en
dc.description.sponsorshipThis work was supported by JSPS KAKENHI Grant Number JP21K14103, ERATO (JPMJER1502, JPMJER1903), and JST-Mirai Program (JPMJMI21G8) from the Japan Science and Technology Agency.en
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/zipen
dc.identifier.citationKoroyasu, Y., Nguyen, T. V., Sasaguri, S., Marzo, A., Ezcurdia, I., Nagata, Y., Yamamoto, T., Nomura, N., Hoshi, T., Ochiai, Y., Fushimi, T. (2023) Microfluidic platform using focused ultrasound passing through hydrophobic meshes with jump availability. PNAS Nexus, 2(7), 1-10. https://doi.org/10.1093/pnasnexus/pgad207.es_ES
dc.identifier.doi10.1093/pnasnexus/pgad207
dc.identifier.issn2752-6542
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/48143
dc.language.isoengen
dc.publisherOxford University Pressen
dc.relation.ispartofPNAS Nexus (2023), vol. 2(7)es_ES
dc.relation.publisherversionhttps://doi.org/10.1093/pnasnexus/pgad207
dc.rights© The Author(s) 2023. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMicrofluidicsen
dc.subjectUltrasounden
dc.subjectHydrophobicen
dc.subjectAutomationen
dc.titleMicrofluidic platform using focused ultrasound passing through hydrophobic meshes with jump availabilityen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationfcb7debc-7861-42ef-ab45-15eceaf48562
relation.isAuthorOfPublicationc267fa59-ec06-43e9-848b-6bcfb85b6d96
relation.isAuthorOfPublication.latestForDiscoveryfcb7debc-7861-42ef-ab45-15eceaf48562

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