Ultrahigh sensitive detection of tau protein as Alzheimer's biomarker via microfluidics and nanofunctionalized optical fiber sensors

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dc.contributor.authorChiavaioli, Francesco
dc.contributor.authorSantano Rivero, Desiree
dc.contributor.authorDel Villar, Ignacio
dc.contributor.authorSocorro Leránoz, Abián Bentor
dc.contributor.authorZhang, Xuejun
dc.contributor.authorLi, Kaiwei
dc.contributor.authorSantamaría Martínez, Enrique
dc.contributor.authorFernández Irigoyen, Joaquín
dc.contributor.authorBaldini, Francesco
dc.contributor.authorVan den Hove, Daniel L. A.
dc.contributor.authorShi, Lei
dc.contributor.authorBi, Wei
dc.contributor.authorGuo, Tuan
dc.contributor.authorGiannetti, Ambra
dc.contributor.authorMatías Maestro, Ignacio
dc.contributor.departmentInstitute of Smart Cities - ISCen
dc.contributor.departmentIngeniería Eléctrica y Electrónicaes_ES
dc.contributor.departmentIngeniaritza Elektrikoa eta Elektronikoaeu
dc.contributor.funderUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoaes
dc.date.accessioned2023-05-09T06:20:48Z
dc.date.available2023-05-09T06:20:48Z
dc.date.issued2022
dc.date.updated2023-05-09T05:59:41Z
dc.description.abstractAlzheimer’s disease (AD) is one of the most common neurodegenerative illnesses displaying the highest death rate in the elderly. However, the existing AD diagnostic system remains elusive due to lack of a technology that may ensure enough sensitivity and reproducibility, detection accuracy, and specificity. Herein, a straightforward approach is reported to realize lab-on-fiber (LoF) technology for AD biomarker detection based on a D-shaped single-mode fiber combined with nanometer-scale metal-oxide film. The proposed sensing system, which permits the generation of lossy-mode resonance (LMR), remarkably increases the evanescent field of light guided through the fiber, and hence the fiber-surrounding medium interaction. Moreover, such optical sensors are highly repeatable in results and can safely be embedded into a compact and stable microfluidic system. Herein, the specific detection of Tau protein (as one of the classical AD biomarkers that is highly correlated with AD progression) in a complex biofluid with a detection limit of 10 12 M and over a wide concentration range (10 3 –10 μg mL 1 ) is successfully demonstrated. The proposed LoF biosensor is an appealing solution for rapid, sub-microliter dose and highly sensitive detection of analytes at low concentrations, hereby having the potential toward early screening and personalized medicine in AD.en
dc.description.sponsorshipF.C. gratefully acknowledges the support of the National Research Council of Italy (CNR) for the Short-Term Mobility programs 2017 and 2019. I.D.V. and I.R.M. acknowledge partial support of the Spanish Ministry of Economy and Competitiveness (Nos.TEC2016-79367-C2-2-R and PID2019-106231RB-I00), the predoctoral research grants of the Public University of Navarra and the Public University of Navarra grant PJUpna1936. E.S. and J.F-I. acknowledge partial support of the Spanish Ministry of Science, Innovation and Universities (PID2019-110356RB-I00/AEI/10.13039/501100011033). T.G.gratefully acknowledges the support of the National Natural Science Foundation of China (Nos. 62035006, 61975068, and 62011530459), the Guangdong Outstanding Scientific Innovation Foundation (No.2019TX05X383), and the Program of Marine Economy Development Special Fund (Six Marine Industries) under Department of Natural Resources of Guangdong Province (No. GDNRC [2021]33).en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationChiavaioli, F., Santano Rivero, D., Del Villar, I., Socorro‐Leránoz, A. B., Zhang, X., Li, K., Santamaría, E., Fernández-Irigoyen, J., Baldini, F., Van Den Hove, D. L. A., Shi, L., Bi, W., Guo, T., Giannetti, A., & Matias, I. R. (2022). Ultrahigh sensitive detection of tau protein as alzheimer’s biomarker via microfluidics and nanofunctionalized optical fiber sensors. Advanced Photonics Research, 3(11), 2200044. https://doi.org/10.1002/adpr.202200044en
dc.identifier.doi10.1002/adpr.202200044
dc.identifier.issn2699-9293
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/45253
dc.language.isoengen
dc.publisherWileyen
dc.relation.ispartofAdvanced Photonics Research, 2022, 3, 2200044en
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106231RB-I00/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-110356RB-I00/ES/
dc.relation.publisherversionhttps://doi.org/10.1002/adpr.202200044
dc.rights© 2022 The Authors. This is an open access article under the terms of the CreativeCommons Attribution License, which permits use, distribution andreproduction in any medium, provided the original work is properly cited.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAlzheimer's diseaseen
dc.subjectTau proteinen
dc.subjectBiomarkersen
dc.subjectEarly detectionen
dc.titleUltrahigh sensitive detection of tau protein as Alzheimer's biomarker via microfluidics and nanofunctionalized optical fiber sensorsen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
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