Glutathione-magnetite nanoparticles: synthesis and physical characterization for application as MRI contrast agent

dc.contributor.authorBeato López, Juan Jesús
dc.contributor.authorDomínguez, M.
dc.contributor.authorRamírez del Solar, M.
dc.contributor.authorLitrán, R.
dc.contributor.departmentZientziakeu
dc.contributor.departmentInstitute for Advanced Materials and Mathematics - INAMAT2en
dc.contributor.departmentCienciases_ES
dc.date.accessioned2021-04-07T07:20:55Z
dc.date.available2021-06-08T23:00:11Z
dc.date.issued2020
dc.description.abstractIn this work a one-pot synthesis of water soluble glutathione capped magnetite nanoparticles is reported. The magnetic characterization of the samples shows the expected superparamagnetic behavior, but a wide range of blocking temperatures is found, since the size and interparticle interactions are very sensitive to preparation conditions. These properties are correlated with the glutathione-iron ratio and oxidant dose, in order to optimize the aqueous colloidal stability and magnetic properties of the superparamagnetic iron oxide nanoparticles for Magnetic Resonance Imaging applications. The efficiency of the glutathione coated nanoparticles as contrast agent is then evaluated by means of the determination of the relaxation times T1 and T2 in H-1 Nuclear Magnetic Resonance experiments. Moreover, the influence of the thickness of the glutathione capping layer on the colloidal stability and, thus, on relaxation times has been studied. Finally, the relaxitivity of the sample that shows the best performance has been determined.en
dc.description.sponsorshipThis research was supported by the Innovation and Science Ministry (PN/PETRI/PR/2007-019) and the Ministry of Economics and Competitiveness (PI16/00784) of the government of Spain.en
dc.embargo.lift2021-06-08
dc.embargo.terms2021-06-08
dc.format.extent49 p.
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1007/s42452-020-3010-y
dc.identifier.issn2523-3971 (Electronic)
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/39493
dc.language.isoengen
dc.publisherSpringeren
dc.relation.ispartofSN Applied Sciences, 2020, 2, 1202en
dc.relation.publisherversionhttps://doi.org/10.1007/s42452-020-3010-y
dc.rights© Springer Nature Switzerland AG 2020en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectMagnetic nanoparticleen
dc.subjectSuperparamagnetismen
dc.subjectMRI contrast agenten
dc.subjectColloidal solubilityen
dc.subjectNanoparticle interactionen
dc.subjectGlutathioneen
dc.titleGlutathione-magnetite nanoparticles: synthesis and physical characterization for application as MRI contrast agenten
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication2b9d0359-605c-4baf-ab4f-fac162ac85dc
relation.isAuthorOfPublication.latestForDiscovery2b9d0359-605c-4baf-ab4f-fac162ac85dc

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